锌指蛋白ZBTB38是ZBTB锌指蛋白亚家族的新成员,与已知的BCL6和PLZF 同源。通过相关研究,学者们发现ZBTB38在生长发育、肿瘤发生、细胞骨架组织、干细胞稳态以及转录调节、造血、染色质重塑、蛋白降解中发挥重要的作用。ZBTB38表达或功能异常可导致个体发育障碍,与肿瘤和朊病毒病等多种重大疾病的病理生理过程密切相关。随着快速的技术发展,特别是单核苷酸多态性,基因组学杂交,全基因组测序的研究,发现ZBTB38基因与人类身高有着很强的关联关系。本文就锌指蛋白ZBTB38调控生长发育做一综述。
Abstract
Zinc finger protein ZBTB38 is a new member of the ZBTB zinc finger protein subfamily,homologous to known BCL6 and PLZF.Through the study,scholars have found that ZBTB38 plays an important role in growth and development,tumorigenesis,cytoskeletal tissue,stem cell homeostasis and transcription regulation,hematopoiesis,chromatin remodeling and protein degradation.Abnormal expression or dysfunction of ZBTB38 can lead to individual developmental disorders and is closely related to the pathophysiological process of tumor,prion disease and other major diseases.With the rapid development of technology,especially single nucleotide polymorphism,genomic hybridization,genome sequencing research,ZBTB38 gene was found to have strong correlation with human height.Zinc finger protein ZBTB38 regulating growth and development is reviewed in this paper.
关键词
锌指蛋白 /
ZBTB38 /
生长发育
Key words
zinc finger protein /
ZBTB38 /
growth and development
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基金
山东省自然科学基金(ZR2014HP058)
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