早产儿追赶性生长与代谢综合征的关联性研究进展

王思弦; 梁琨

doi:10.11852/zgetbjzz2018-1690

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中国儿童保健杂志 ›› 2019, Vol. 27 ›› Issue (7) : 745-748. DOI: 10.11852/zgetbjzz2018-1690

综述

早产儿追赶性生长与代谢综合征的关联性研究进展

王思弦, 梁琨

作者信息 +

Recent advances in catch-up growth and metabolic syndrome of premature infants

WANG Si-xian, LIANG Kun

Author information +

文章历史 +

摘要

代谢综合征(MS)又称胰岛素抵抗综合征,主要包括Ⅱ型糖尿病、肥胖、血糖调节异常、高血压和血脂异常等。早产儿追赶性生长可以弥补早产儿宫外发育迟缓的缺陷,提高其免疫功能,促进其智力运动的发育。但研究表明,追赶性生长与MS关系密切。本文主要对早产儿追赶性生长致成人期发生MS的机制、早期预测及干预进行综述。

Abstract

Metabolic syndrome (MS),also known as insulin resistance syndrome,mainly includes type 2 diabetes,obesity,abnormal blood glucose regulation,hypertension and dyslipidemia.Catch-up growth of preterm infants may compensate to the deficiency of extrauterine growth retardation,improve innate immune function,and promote mental and physical development.But it has been shown that catch-up growth is closely related to MS.This review summarizes the mechanism,early prediction and intervention of MS in adulthood caused by catch-up growth in preterm infants

导出引用

王思弦, 梁琨. 早产儿追赶性生长与代谢综合征的关联性研究进展[J]. 中国儿童保健杂志. 2019, 27(7): 745-748 https://doi.org/10.11852/zgetbjzz2018-1690

WANG Si-xian, LIANG Kun. Recent advances in catch-up growth and metabolic syndrome of premature infants[J]. Chinese Journal of Child Health Care. 2019, 27(7): 745-748 https://doi.org/10.11852/zgetbjzz2018-1690

中图分类号： R722.6

参考文献

[1] Quilter CR,Cooper WN,Cliffe KM,et al.Impact on offspring methylation patterns of maternal gestational diabetes mellitus and intrauterine growth restraint suggest common genes and pathways linked to subsequent type 2 diabetes risk[J].FASEB Journal,2014;28(11):4868-4879.
[2] 周玉润,陈婕,孙建乐,等.低出生体重儿追赶性生长跨度与儿童期超重肥胖的相关性研究[J].中国儿童保健杂志,2018,26(3):236-238,250.
[3] Wang X,Zhu J,Guo C,et al.Growth of infants and young children born small for gestational age:growth restriction accompanied by overweight[J].J Int Med Res,2018,46 (9):3765-3777.
[4] Ju L,Tong W,Qiu M,et al.Endurance exercise ameliorates low birthweight developed catch-up growth related metabolic dysfunctions in a mouse model[J].Endocr J,2016,63(3):275-285.
[5] Tanner JM.Catch-up growth in man[J].Br Med Bull,1981,37(3):233-238.
[6] Cianfarani S,Geremia C,Germani D,et al.Insulin resistance and insulin-like growth factors in children with intrauterine growth retardation[J].Horm Res,2001,55(1):7-10.
[7] Sebastiani G,Díaz M,Bassols J,et al.The sequence of prenatal growth restraint and post-natal catch-up growth leads to a thicker intima-media and more pre-peritoneal and hepatic fat by age 3-6 years[J].Pediatr Obes,2016,11(4):251-257.
[8] 袁超,刘永斌,夏利平,等.孕期摄食限制对雌性子代老年大鼠代谢综合征易感的影响[J].环境与健康杂志,2017,34(3):189-193.
[9] Berends LM,Dearden L,Tung YCL,et al.Programming of central and peripheral insulin resistance by low birthweight and postnatal catch-up growth in male mice [J].Diabetologia,2018,61(10):2225-2234.
[10] 王雪茵,赵更力,周敏,等.早产儿786例体格生长的纵向随访研究[J].中国儿童保健杂志,2017,25(10):1002-1005,1011.
[11] Okada T,Takahashi S,Nagano N,et al.Early postnatal alteration of body composition in preterm and small-for-gestational-age infants:implications of catch-up fat[J].Pediatr Res,2014,77(1-2):136-142.
[12] Singhal A,The role of infant nutrition in the global epidemic of noncommunicable disease[J].Proc Nutr Soc,2016,75(2):162-168.
[13] Embleton ND,Korada M,Wood CL,et al.Catch-up growth and metabolic outcomes in adolescents born preterm[J].Arch Dis Child,2016,101(11):1026-1031.
[14] Ramírez-Vélez R,Correa-Bautista JE,Villa-González E,et al.Effects of preterm birth and fetal growth retardation on life-course cardiovascular risk factors among school children from Colombia:the fuprecol study[J].Early Hum Dev,2017,106-107:53-58.
[15] Ediriweera DS,Dilina N,Perera U,et al.Risk of low birth weight on adulthood hypertension - evidence from a tertiary care hospital in a South Asian country,Sri Lanka:a retrospective cohort study[J].BMC Public Health,2017,17(1):358.
[16] Matta J,Carette C,Levy Marchal C,et al.Weight for gestational age and metabolically healthy obesity in adults from the Haguenau cohort[J].BMJ Open,2016,6(8):e011367.
[17] Hanvey AN,Mensah FK,Clifford SA.Adolescent cardiovascular functional and structural outcomes of growth trajectories from infancy:prospective community-based study [J].Child Obes,2017,13 (2):154-163.
[18] Tzschoppe A,von Kries R,Struwe E,et al.Intrauterine gro wth restriction (IUGR) induces signs of subclinical atherosclerosis in 6-year-old infants despite absence of excessive growth [J].Klin Padiatr,2017,229 (4):209-215.
[19] Andersen GS,Wibaek R,Kaestel P,et al.Body Composition Growth Patterns in Early Infancy:A latent class trajectory analysis of the ethiopian iABC birth cohort[J].Obesity,2018,26 (7):1225- 1233.
[20] McCloskey K,De Livera AM,Collier F,et al.Gestational age and the cord blood lipidomic profile in late preterm and term infants[J].Neonatology,2018,114 (3):215-222.
[21] Posod A,Müller S,Komazec IO,et al.Former very preterm infants show alterations in plasma amino acid profiles at a preschool age[J].Pediatr Res,2017,81(5):787-794.
[22] 李瑞香,胡燕.Ghrelin与小于胎龄儿追赶生长的研究进展[J].儿科药学杂志,2017,23(1):63-66.
[23] Mól N,Zasada M,Tomasik P,et al.Evaluation of irisin and visfatin levels in very low birth weight preterm newborns compared to full term newborns-a prospective cohort study[J].PLoS One,2018,13(9):e0204835.
[24] Joung KE,Cataltepe SU,Michael Z,et al.Cord blood adipocyte fatty acid-binding protein levels correlate with gestational age and birth weight in neonates [J].J Cli Endocrinol Metab,2017,102(5):1606-1613.
[25] 周宁,颜贤忠.代谢性疾病的代谢组学研究进展[J].国际药学研究杂质,2015,42(5):561-567,573.
[26] Stevens A,Bonshek C,Whatmore A,et al.Insights into the pathophysiology of catch-up compared with non-catch-up growth in children born small for gestational age:an integrated analysis of metabolic and transcriptomic data[J].Pharmacogenomics J,2014,14(4):376-384.
[27] Hellmuth C,Uhl O,Demmelmair H,et al.The impact of human breast milk components on the infant metabolism[J].PloS One,2018,13(6):e0197713.
[28] Haschke F,Grathwohl D.Metabolic programming:effects of early nutrition on growth,metabolism and body composition[J].Nestle Nutr Inst Workshop Ser,2016,86(11):87-95.
[29] 周玉润,林颖,孙建乐,等.温州市3625例早产儿体格生长状况分析[J].预防医学,2017,29(7):740-743,747.
[30] Gao M,Deng XL,Liu ZH,et al.Liraglutide protects β-cell function by reversing histone modifi- cation of Pdx-1 proximal promoter in catch-up growth male rats[J].J Diabetes Complications,2018,32(11):985-994.