生物钟与肥胖

郁珽; 李晓南

doi:10.11852/zgetbjzz2018-1170

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中国儿童保健杂志 ›› 2018, Vol. 26 ›› Issue (12) : 1327-1331. DOI: 10.11852/zgetbjzz2018-1170

综述与讲座

生物钟与肥胖

郁珽, 李晓南

作者信息 +

Circadian clock and obesity

YU Ting, LI Xiao-nan

Author information +

文章历史 +

摘要

生物钟调控机体的生理和行为呈现周期为24 h的昼夜节律。越来越多的证据显示昼夜节律的破坏与肥胖及其并发症的发生发展密切相关,但其中的机制尚不明确。大量研究表明生物钟可能通过影响各种内分泌激素及脂肪因子的分泌节律调节机体的新陈代谢及能量稳态。深入研究生物钟与肥胖的相互作用可能为肥胖的防治,尤其是儿童期肥胖提供新的思路和治疗策略。

Abstract

The circadian rhythms of physiology and behaviors are driven by an intrinsic machinery called the circadian clock, which generates rhythms with a periodicity of about 24 hours.Accumulating evidence suggest that the disruption of circadian rhythms is closely related to the development of obesity and its clinical complications.However,the mechanism is incompeletely understood.Researches indicate that the circadian clock regulates metabolism and energy homeostasis by affecting rhythmic release of various endocrine hormones and adipokines.Further study on the interaction between the circadian clock and obesity may provide new ideas and therapeutic strategies for the prevention and treatment of obesity,especially childhood obesity

导出引用

郁珽, 李晓南. 生物钟与肥胖[J]. 中国儿童保健杂志. 2018, 26(12): 1327-1331 https://doi.org/10.11852/zgetbjzz2018-1170

YU Ting, LI Xiao-nan. Circadian clock and obesity[J]. Chinese Journal of Child Health Care. 2018, 26(12): 1327-1331 https://doi.org/10.11852/zgetbjzz2018-1170

中图分类号： R723.14

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