目的 分析不同出生胎龄早产儿智能发育情况,为早产儿保健提供指导。方法 选择自2012年2月-2015年12月在广州市妇女儿童医疗中心儿童保健科接收发育评估的2 579名婴幼儿为观察对象,分为中期早产儿(MPT)组(32+0/7~33+6/7周)、晚期早产儿(LPT)(34+0/7~36+6/7周) 组、早期足月儿(ET)组(37+0/7~38+6/7周)和足月儿(FT)组(39+0/7~40+6/7周)。采用Gesell量表对所有研究对象进行神经发育水平评估,并比较各组差异。结果 以FT组作为参照,MPT组、LPT组和ET组神经发育迟缓的风险增高,OR值分别为2.38(95%CI:1.18~4.78)、1.63(95%CI:1.07~2.48)、1.42(95%CI:1.12~1.81)。结论 中晚期早产儿相比足月儿发生神经发育迟缓的风险比例增高,而早期足月儿同样风险比例增高,孕周与发育迟缓的风险呈现一个剂量效应。
Abstract
Objective To analyze the intelligence development of preterm with different gestational ages,in order to provide suggestions for healthcare of premature infants. Methods A total of 2 579 children aged 6-24 months in Guangzhou Women and Children's Medical Center were enrolled in this study from February 2012 to December 2015. And the participants were divided into four groups according to gestational age,including moderate preterm (MPT) (32+0/7-33+6/7weeks),late preterm (LPT)(34+0/7-36+6 weeks),early term (ET)(37+0/7-38+6 weeks) and full-term (FT)(39+0/7-41+6 weeks) infants. Gesell development Scale was used to assess the neurodevelopment of participants,and the difference among four groups were compared. Results Compared with those born full term,the risk of neurodevelopmental delay in MPT(OR=2.38,95%CI:1.18-4.78),LPT(OR=1.63,95%CI:1.07-2.48) and ET(OR=1.42,95%CI:1.12-1.81) infants were much higher. Conclusions Moderate,late and early preterm increase the risk of delayed neurodevelopment proportion compared with full term infants. And an inverse dose-response relationship between gestational age and risk of developmental delay is found in the tested children.
关键词
早产儿 /
发育迟缓 /
发育商
Key words
preterm birth /
development delay /
developmental quotient
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参考文献
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基金
广州市医药卫生科技项目(20161A011023)
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