目的 分析儿童睑板腺囊肿的发病原因与血清维生素水平及饮食习惯相关性研究,以期为临床防治提供依据,避免不良预后。方法 2016-2017年在复旦大学附属儿科医院眼科就诊的患儿中,随机选择睑板腺囊肿术前患儿共108例为病例组,斜视或倒睫术前患儿共48例为对照组。两组患儿均抽血检验其血清维生素A、B1、C、D、E的水平,采取独立两样本t检验分析两组间的差异。通过问卷调查两组儿童高热量食物摄入比例、主食零食摄入偏好、荤素摄入偏好、是否偏食,χ2检验分析两组间的差异,Logistic回归模型进行多因素分析。结果 病例组的血清维生素A水平为(0.64±0.14)μmol/L,对照组为(0.70±0.21)μmol/L,差异有统计学意义(P=0.014)。病例组囊肿多发的患儿血清维生素A水平较单发的患儿偏低(P=0.006)。病例组的血清维生素B1、C、D、E水平与对照组之间差异均无统计学意义(P＞0.05)。病例组和对照组在高热量食物摄入比例、主食零食摄入偏好、荤素摄入偏好以及是否偏食方面差异均无统计学意义(P＞0.05),Logistic回归分析显示上述饮食习惯差异均不是儿童睑板腺囊肿发病的独立危险因素(P＞0.05)。结论 低维生素A水平与儿童睑板腺囊肿的发病有关,尤其是囊肿多发患儿。
Abstract
Objective Toinvestigate the etiology of chalazia in children,in order to provide basis for clinical prevention and treatment of chalazia. Methods Totally 108 preoperative children with chalazia were randomly selected as the case group from 2016 to 2017 in Children's Hospital of Fudan University,and 48 preoperative children with strabismus or trichiasis were as the control group. Serum vitamin A,B1,C,D,E of children were tested and compared in two groups using two independent samples t test. Questionnaires survey was conducted to investigate high-calorie food,snacks and meat consumption and dietary bias in two groups. Chi-square test and Logistic regression were used to analyze the data. Results The average serum vitamin A level of the case group was (0.64±0.14)μmol/L,the control group was (0.70±0.21 )μmol/L,and the difference between the two groups was statistically significant(P=0.014). Serum vitamin A levels in children with multiple cysts were lower than those of children with single cyst(P=0.006). There were no significant differences on serum vitamin B1,C,D and E levels between the two groups(P>0.05). But there were no significant differences on high-calorie food,snacks and meat consumption and dietary bias between case group and control group(P>0.05). Logistic regression analysis showed significant effect of eating habits to chalazia in children was not found(P>0.05). Conclusion Low vitamin A level is associated with chalazia in children,especially in children with multiple cysts.
关键词
睑板腺囊肿 /
维生素 /
饮食习惯 /
病因学 /
儿童
Key words
chalazia /
vitamin /
eating habits /
etiology /
children
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参考文献
[1] Park YM,Lee JS.The effects of chalazion excision on corneal surface aberrations[J].Cont Lens Anterior Eye,2014,37(5):342-345.
[2] Schear MJ,Milman T,Steiner T,et al.The association of demodex with chalazia:a Histopathologic study of the eyelid[J].Ophthal Plast Reconstr Surg,2016,32(4):275-278.
[3] Hickey CS.The use of vitamin A in the prevention and treatment of chalazion[J].Eye Ear Nose Throat Mon,1951,30(9):488-490.
[4] Mansour AM,Chan CC,Crawford MA,et al.Virus-induced chalazion[J].Eye(Lond),2006,20(2):242-246.
[5] Aoki M,Kawana S.Bilateral chalazia of the lower eyelids associated with pulmonary tuberculosis[J].Acta Derm Venereol,2002,82(5):386-387.
[6] Song P,Wang J,Wei W,et al.The Prevalence of Vitamin A Deficiency in Chinese Children:A Systematic Review and Bayesian Meta-Analysis[J].Nutrients,2017,9(12):1285-1293.
[7] 赵柳宁,邓娟.睑板腺囊肿的研究进展[J].国际眼科纵览,2015,39(3):145-151.
[8] Grob SR,Jakobiec FA,Rashid A,et al.Chalazia associated with bortezomib therapy for multiple myeloma[J].Ophthalmology,2014,121(9):1845-1847.
[9] Yun C,Mukhi N,Kremer V,et al.Chalazia development in multiple myeloma:a new complication associated with bortezomib therapy[J].Hematol Rep,2015,7(2):38-40.
[10] Gupta S,Silliman CG,Trump DL.Docetaxel-induced Meibomian duct inflammation and blockage leading to chalazion formation[J].Prostate Cancer Prostatic Dis,2007,10(4):396-397.
[11] Murdaugh DL,Cox JE,Cook ER,et al.fMRI reactivity to high-calorie food pictures predicts short- and long-term outcome in a weight-loss program[J].Neuroimage,2012,59(3):2709-2721.
[12] McCullough FS,Northrop-Clewes CA,Thurnham DI.The effect of vitamin A on epithelial integrity[J].Proc Nutr Soc,1999,58(2):289-293.
[13] Abboud IA,Osman HG,Massoud WH.Vitamin A and chalazia[J].Exp Eye Res,1968,7(3):383-387.
[14] Albert,Daniel M.Albert & Jakobiec's principles and practice of ophthalmology[M].3rd ed.Philadelphia,Philadelphia:Saunders Elsevier Press,2008:625-627.
[15] Chen L,Chen X,Xiang Q,et al.Prevalence of low serum vitamin a levels in young children with chalazia in southwest china[J].Am J Ophthalmol,2014,157(5):1103-1108.
[16] Malekahmadi M,Farrahi F,Tajdini A.Serum vitamin A levels in patients with chalazion[J].Med Hypothesis Discov Innov Ophthalmol,2017,6(3):63-66.
[17] World Health Organization.Global prevalence of vitamin A deficiency in populations at risk 1995-2005:WHO global database on vitamin A deficiency[M].Geneva:World Health Organization,2009:55.
[18] 林萍,刘彦芳,武志清.儿童多发性睑板腺囊肿的相关危险因素分析[J].国际眼科杂志,2018,18(4):751-753.
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