目的 研究高亮度蓝色LED灯箱照射治疗新生儿黄疸的有效性及安全性,为新生儿黄疸的治疗提供依据。方法 选取2013年8月-2018年1月西安市北方医院收治的新生儿黄疸200例,根据治疗方法不同分为对照组和观察组。对照组患儿采用常规药物治疗+蓝色日光灯管箱照射治疗,观察组患儿采用常规药物治疗+高亮度蓝色 LED 灯箱照射治疗,分析两组患儿治疗后的临床效果。结果 观察组患儿黄疸消退时间、住院时间短于对照组,日胆红素下降值高于对照组,差异有统计学意义(P<0.05)。治疗前,两组患儿血清胆红素、C反应蛋白(CRP)、神经元特异性烯醇化酶(NSE)、碱性磷酸酶(ALP)、游离脂肪酸(FFA)水平比较,差异无统计学意义(P>0.05)。治疗后,两组患儿血清胆红素、CRP、NSE、ALP、FFA水平均较治疗前下降,观察组患儿血清胆红素、CRP、NSE、ALP、FFA水平低于对照组,差异有统计学意义(P<0.05)。观察组患儿不良反应率为22.00%(22/100),对照组为45.00%(45/100),观察组患儿不良反应率低于对照组,差异有统计学意义(P<0.05)。结论 高亮度蓝色LED灯箱照射治疗新生儿黄疸可加快黄疸消退,降低血清胆红素、CRP、NSE水平,且不良反应少,安全性高。

Objective To study the effect of high brightness blue LED light box irradiation on neonatal jaundice,in order to provide reference for the treatment of neonatal jaundice. Methods Totally 200 cases of neonatal jaundice were enrolled in this study from August 2013 to January 2018,and were divided into control group and observation group.The control group was treated with conventional drugs,and the observation group was treated with high brightness blue LED light box irradiation additionally.The clinical effects of the two groups were analyzed. Results The jaundice regression time and hospitalization time were shorter in observation group than those in control group,and the daily bilirubin decreased value was higher than that in the control group (P <0.05).Before treatment,there were no significant differences on serum bilirubin level,C-reactive protein (CRP),neuron-specific enolase (NSE),alkaline phosphates (ALP) and free fatty acid (FFA) between the two groups (P>0.05).After treatment,the levels of serum bilirubin,CRP,NSE,ALP and FFA in the observation group were significantly lower than those in the control group (P<0.05).The adverse reaction rate was 22.00% (22/100) in the observation group and 45.00% (45/100) in the control group,and the difference was significant (P<0.05). Conclusion High brightness blue LED lamp box can accelerate jaundice regression,reduce the serum bilirubin level in neonatal jaundice children,with few adverse reactions and high safety.