孕期维生素D缺乏对孕母及后代影响的研究进展

张颖宽 综述, 仰曙芬 审校

中国儿童保健杂志 ›› 2019, Vol. 27 ›› Issue (2) : 160-163.

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中国儿童保健杂志 ›› 2019, Vol. 27 ›› Issue (2) : 160-163. DOI: 10.11852/zgetbjzz2018-0560
综述

孕期维生素D缺乏对孕母及后代影响的研究进展

  • 张颖宽 综述, 仰曙芬 审校
作者信息 +

Research progress on the influence of vitamin D deficiency during pregnancy on pregnant women and their offsprings

  • ZHANG Ying-kuan,YANG Shu-fen
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文章历史 +

摘要

维生素D(Vit D)缺乏属于全球范围内的一个常见的公共卫生问题。在孕母及后代Vit D缺乏现象尤其多见。Vit D缺乏不仅可导致骨骼方面的疾病,还与过敏性疾病、1型糖尿病、心血管疾病、肿瘤、自身免疫性疾病、神经行为疾病的发生有关。人们越来越担心孕期Vit D缺乏对孕母及后代生命健康会产生不利的影响。本文主要从孕期Vit D缺乏对孕母及后代生命健康的影响进行综述,以期提高孕母补充Vit D的意识,实现优生优育。

Abstract

Vitamin D (Vit D) deficiency is a common public health problem worldwide, especially in pregnant women and their offsprings.Vit D deficiency can not only cause diseases in bone, but also correlate with allergic diseases, type 1 diabetes, cardiovascular diseases, tumors, autoimmune diseases and neurobehavioral diseases.So there are increasing concerns that maternal Vit D deficiency could adversely affect the life and health of pregnant women and their offsprings.This review summarizes the impact of Vit D deficiency on the health of pregnant women and their offsprings, in order to improve maternal awareness of Vit D supplementation and achieve eugenics.

关键词

孕母 / 后代 / 维生素D / 维生素D缺乏

Key words

pregnant women / offspring / vitamin D / vitamin D deficiency

引用本文

导出引用
张颖宽 综述, 仰曙芬 审校. 孕期维生素D缺乏对孕母及后代影响的研究进展[J]. 中国儿童保健杂志. 2019, 27(2): 160-163 https://doi.org/10.11852/zgetbjzz2018-0560
ZHANG Ying-kuan,YANG Shu-fen. Research progress on the influence of vitamin D deficiency during pregnancy on pregnant women and their offsprings[J]. Chinese Journal of Child Health Care. 2019, 27(2): 160-163 https://doi.org/10.11852/zgetbjzz2018-0560
中图分类号: R715.3   

参考文献

[1] Yu CK, Sykes L, Sethi M, et al.Vitamin D deficiency and supplementation during pregnancy[J]. Clin Endocrinol(Dxf),2009,70(5):685-690.
[2] Hollis BW, Wagner CL.Vitamin D supplementation during pregnancy:improvements in birth outcomes and complications through direct genomic alteration[J].Mol Cell Endocrinol,2017,453:113-130.
[3] Mller UK, Streym S, Mosekilde L, et al.Changes in calcitropic hormones, bone markers and insulin-like growth factor I (IGF-I) during pregnancy and postpartum:a controlled cohort study[J]. Osteoporos Int,2013,24(4):1307-1320.
[4] Maladkar M, Sankar S, Kamat K.Vitamin D efficiency in pregnancy:an updated viewpoint in Indian Scenario[J]. International Journal of Clinical Medicine,2016,6(3):204-216.
[5] Schulz EV, Cruze L, Wei W, et al.Maternal vitamin D sufficiency and reduced placental gene expression in angiogenic biomarkers related to comorbidities of pregnancy[J].J Steroid Biochem Mol Biol,2017,173:273-279.
[6] Barrera D,Díaz L, Noyolamartínez N, et al.Vitamin D and inflammatory cytokines in healthy and preeclamptic pregnancies[J]. Nutrients,2015,7(8):6465-6490.
[7] Blomberg JM, Gerner LJ, Andersson AM, et al.Vitamin D deficiency and low ionized calcium are linked with semen quality and sex steroid levels in infertile men[J]. Hum Reprod,2016,31(8):1875-1885.
[8] Berridge MJ.Vitamin D cell signalling in health and disease[J]. Biochem Biophys Res Commun,2015,460(1):53-71.
[9] Ali AM,Alobaid A, Malhis TN, et al.Effect of vitamin D3 supplementation in pregnancy on risk of preeclampsia - randomized controlled trial[J]. Clin Nutr,2018,pii:S0261-5614(18)30088-8.
[10] Akbari S, Khodadadi B, Ahmadi SAY, et al.Association of vitamin D level and vitamin D deficiency with risk of preeclampsia:a systematic review and updated meta-analysis[J]. Taiwan J Obstet Gynecol,2018,57(2):241-247.
[11] Purswani JM, Gala P, Dwarkanath P, et al.The role of vitamin D in pre-eclampsia:a systematic review[J]. BMC Pregnancy Childbirth,2017,17(1):231.
[12] 张雅君, 赵丽, 王若琪,等.妊娠糖尿病与维生素D的相关性研究[J]. 海南医学,2017,28(20):3322-3324.
[13] Zhang Q, Cheng Y, He M, et al.Effect of various doses of vitamin D supplementation on pregnant women with gestational diabetes mellitus:a randomized controlled trial[J]. Exp Ther Med,2016,12(3):1889-1895.
[14] Wimalawansa SJ.Vitamin D adequacy and improvements of comorbidities in persons with intellectual developmental disabilities[J]. J Child Dev Disord,2016,2(3):22-33.
[15] Akoh CC, Pressman EK, Cooper E, et al.Low vitamin D is associated with infections and proinflammatory cytokines during pregnancy[J].Reprod Sci,2017,25(2):1933719117715124.
[16] Turner AN, Carr RP, Chen PL, et al.Serum vitamin D status and bacterialvaginosis prevalence and incidence in Zimbabwean women[J]. Am J Obstet Gynecol,2016,215(3):332.e1-332.e10.
[17] Minissian MB, Kilpatrick S, Eastwood JA, et al.Association of spontaneous preterm delivery and future maternal cardiovascular disease[J]. Circulation,2018,137(8):865-871.
[18] Mullins C,Fishell G, Tsien RW.Unifying views of autism spectrum disorders:a consideration of autoregulatory feedback loops[J]. Neuron,2016,89(6):1131-1156.
[19] Zhu H,Wagner C.Maternal vitamin D supplementation and cord blood genome-wide DNA methylation analysis[J]. Vitamin D Workshop,2016,3:29-31.
[20] Alharbi AN, Khan KM, Rahman A.Developmental vitamin D deficiency affects spatial learning in wistar rats[J]. J Nutr,2017,147(9):jn249953.
[21] Hanieh S, Ha TT, Simpson JA, et al.Maternal vitamin D status and infant outcomes in rural vietnam:a prospective cohort study[J]. PLoS One,2014,9(6):e99005.
[22] Hart PH, Lucas RM, Walsh JP, et al.Vitamin d in fetal development:findings from a birth cohort study[J]. Pediatrics,2015,135(1):167-73.
[23] Daraki V, Roumeliotaki T, Koutra K, et al.High maternal vitamin D levels in early pregnancy may protect against behavioral difficulties at preschool age:the Rhea mother-child cohort, Crete, Greece[J]. Eur Child Adolesc Psychiatry,2018,27:79-88.
[24] Darling AL, Rayman MP, Steer CD, et al.Association between maternal vitamin D status in pregnancy and neurodevelopmental outcomes in childhood:results from the Avon Longitudinal Study of Parents and Children (ALSPAC)[J]. Br J Nutr,2017,117(12):1-11.
[25] Vinkhuyzen AA, Eyles DW, Burne TH, et al.Gestational vitamin D deficiency and autism-related traits:the generation R study[J]. Mol Psychiatry,2018,23(2):240-246.
[26] Miettinen ME, Smart MC, Kinnunen L, et al.Maternal VDR variants rather than 25-hydroxyvitamin D concentration during early pregnancy are associated with type 1 diabetes in the offspring[J]. Diabetologia,2015,58(10):2278-83.
[27] Saccone D, Asani F, Bornman L.Regulation of the vitamin D receptor gene by environment, genetics and epigenetics[J]. Gene,2015,561(2):171-180.
[28] Srensen IM, Joner G, Jenum PA, et al.Vitamin D-binding protein and 25-hydroxyvitamin D during pregnancy in mothers whose children later developed type 1 diabetes[J]. Diabetes Metab Res Rev,2016,32(8):883-890.
[29] Jones AP,D′Vaz N, Meldrum S, et al.25-hydroxyvitamin D3 status is associated with developing adaptive and innate immune responses in the first 6 months of life[J]. Clin Exp Allergy,2015,45(1):220-231.
[30] Hornsby E, Pfeffer PE, Laranjo N, et al.Vitamin D supplementation during pregnancy:effect on the neonatal immune system in a randomized controlled trial[J]. J Allergy Clin Immunol,2018,141(1):269-278.
[31] Viljoen K, Segurado R, O′Brien J, et al.Pregnancy diet and offspring asthma risk over a 10-year period:the lifeways cross generation cohort study, Ireland[J]. BMJ Open,2018,8(2).
[32] Pacheco-Gonzalez RM, García-Marcos L.Prenatal vitamin D status and respiratory and allergic outcomes in childhood:a meta-analysis[J]. Pediatr Allergy Immunol,2018,10:1111-12876.
[33] Shin JS, Choi MY, Longtine MS, et al.Vitamin D effects on pregnancy and the placenta[J]. Placenta,2010,31(12):1027-1034.
[34] van der Pligt P, Willcox J.Associations of maternal vitamin D deficiency with pregnancy and neonatal complications in developing countries:a systematic review[J].Nutrients,2018,10(5):E640.
[35] Christopher SK.Bone metabolism in the fetus and neonate[J]. Pediatric Nephrology,2014,29(5):793-803.

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黑龙江省社会发展攻关项目(070400020047)

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