目的 了解中枢性性早熟(CPP)组儿童25-羟维生素D[25(OH)D]水平和区间分布,分析CPP儿童性激素与25(OH)D水平的相关性。方法 以2015年本院内分泌科确诊的182例CPP患儿为研究对象,选择同期在儿童保健科健康体检的同年龄段儿童200例为对照组,采用电化学分析检测血浆25(OH)D水平,并将25(OH)D水平与黄体生成素(LH)/卵泡刺激素(FSH)峰值比进行相关分析。结果 CPP组儿童25(OH)D水平比对照组低[(55.7±16.9)nmol/L vs.(66.5±20.1)nmol/L], 差异有统计学意义(t=5.70, P<0.05),25(OH)D水平与LH/FSH峰值比存在负相关关系(r=-0.74,P<0.05);两组25(OH)D水平构成不同,维生素D缺乏区间CPP占比(39.7%)高于对照组(22.2%),维生素D充足区间CPP占比(16.3%)低于对照组(33.3%)。结论 CPP儿童青春期提前骨骼生长发育快,维生素D需求量大,在儿童性早熟的治疗过程中应加强对维生素D重视,定期监测25(OH)D水平,补充维生素D。

Objective To test the level of 25-hydroxyl vitamin D [25(OH)D] in children with central precocious puberty (CPP), and to analyze the correlation between sex hormones and 25(OH)D. Methods A total of 182 CPP children diagnosed in endocrinology department were enrolled in this study in 2015, and 200 health children at the same age were selected as control group.Plasma level of 25(OH)D was tested by electrochemical analysis, and the correlation between 25(OH)D level and luteinizing hormone (LH)/peak follicle-stimulating hormone (FSH) were analyzed. Results The level of 25(OH)D was significantly lower in CPP group than that in control group [(55.7±16.9) nmol/L vs.(66.5±20.1) nmol/L, t=5.70, P<0.05].The level of 25(OH)D was negatively related to LH/FSH peak(r=-0.74, P<0.05).The proportion of vitamin D deficiency in CCP group(39.7%) was significantly higher than that of control group(22.2%), while the proportion of vitamin D sufficiency(16.3%) was significantly lower than that of control group(33.3%) (P<0.05). Conclusions Because of the early bone growth and development of children with early puberty, vitamin D is in high demand.So in the treatment of sexual precocity, the importance of vitamin D should be strengthened, and regular monitoring of 25(OH)D levels and vitamin D supplements are recommended.