目的 分析212例住院新生儿血浆维生素A(VA)浓度及各种因素对VA浓度的影响,为临床干预提供理论依据。方法 采用高效液相色谱法检测2017年6-12月212例住院新生儿血浆VA浓度。并收集新生儿的基本资料。采用SPSS 19.0统计软件分析各种因素对VA浓度影响。结果 VA缺乏(VAD)189例,比例达89.1%;性别、年龄、血糖、感染、新生儿呼吸窘迫综合征(NRDS)均为影响VA浓度的因素,差异有统计学意义(P<0.05);VA水平与C反应蛋白呈负相关(r=-0.167,P=0.015);母亲VA水平与新生儿VA水平无相关性(P>0.05);性别(OR=0.465,95%CI:0.237~0.913,P=0.026)、感染(OR=2.583,95%CI:1.135~5.876,P=0.024)是临床VAD危险因素。结论 晋城市新生儿VA缺乏状况较严重,男婴感染的新生儿更容易发生临床VA缺乏。
Abstract
Objective To evaluate the level of plasma vitamin A(VA) and the influencing factors of VA level in 212 hospitalized newborns. Methods The plasma level of VA in newborns was tested by high performance liquid chromatography(HPLC) from June to December 2017.And the general data of children were collected.SPSS 19.0 were used to analyze the influencing factors of VA level. Results There were 189(89.1%) cases were detected with VA deficiency. Gender,age,blood glucose,infection and neonatal respiratory distress syndrome(NRDS) were factors influencing VA concentration,and the difference was statistically significant(P<0.05). The level of VA was negatively correlated with C-reaction protein(CRP)(r=-0.167,P=0.015). The correlation between mother and neonates was not statistically significant(P＞0.05).Gender(OR=0.465,95%CI:0.237-0.913,P=0.026) and infection(OR=2.583,95%CI:1.135-5.876,P=0.024) were the risk factors for clinical VA deficiency. Conclusion Vitamin A deficiency in newborns is severe. Male infants and newborns with infection are prone to developing clinical vitamin A deficiency.
关键词
维生素A /
性别 /
感染 /
住院新生儿
Key words
vitamin A /
sex /
infection /
hospitalized newborns
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参考文献
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