硒与n-3多不饱和脂肪酸对甲基汞神经毒性影响的研究进展

王菊; 吴美琴; 颜崇淮

doi:10.11852/zgetbjzz2017-25-10-16

PDF(481 KB)

中国儿童保健杂志 ›› 2017, Vol. 25 ›› Issue (10) : 1034-1037. DOI: 10.11852/zgetbjzz2017-25-10-16

综述与讲座

硒与n-3多不饱和脂肪酸对甲基汞神经毒性影响的研究进展

王菊^1,2,吴美琴²,颜崇淮²

作者信息 +

Influence of selenium and n-3 polyunsaturated fatty acids on methylmercury neurotoxicity:a review

WANG Ju^1,2,WU Mei-qin²,YAN Chong-huai²

Author information +

文章历史 +

摘要

水产品是人类甲基汞暴露的来源之一,同时包含多种对神经系统发育有重要作用的营养物质,如硒、n-3多不饱和脂肪酸。目前,多项研究提示硒与n-3多不饱和脂肪酸对甲基汞神经毒性可能具有潜在的保护作用。本文回顾了硒与n-3多不饱和脂肪酸对甲基汞神经毒性影响的流行病学与实验研究,重点讨论了其与甲基汞可能的相互作用及作用机制,在此基础上对未来的研究方向进行展望。

Abstract

Aquatic products are one of sources of methylmercury exposure for human beings,and also contain a number of nutrients which have significant effects on nervous system development,such as selenium and n-3 polyunsaturated fatty acids.Recent researches have indicated that selenium and n-3 polyunsaturated fatty acids might provide potential protection against methylmercury neurotoxicity.This paper reviewes both epidemiological and experimental studies about the influence of selenium and n-3 polyunsaturated fatty acids on methylmercury neurotoxicity.The possible interaction between two materials and methylmercury,and the underlying mechanisms are discussed as emphases,so as to provide evidence for futher research.

导出引用

王菊,吴美琴,颜崇淮. 硒与n-3多不饱和脂肪酸对甲基汞神经毒性影响的研究进展[J]. 中国儿童保健杂志. 2017, 25(10): 1034-1037 https://doi.org/10.11852/zgetbjzz2017-25-10-16

WANG Ju,WU Mei-qin,YAN Chong-huai. Influence of selenium and n-3 polyunsaturated fatty acids on methylmercury neurotoxicity:a review[J]. Chinese Journal of Child Health Care. 2017, 25(10): 1034-1037 https://doi.org/10.11852/zgetbjzz2017-25-10-16

中图分类号： R179

参考文献

[1] Guzzi G,La Porta CA.Molecular mechanisms triggered by mercury[J].Toxicology,2008,244(1):1-12.
[2] Choi AL,Mogensen UB,Bjerve KS,et al.Negative confounding by essential fatty acids in methylmercury neurotoxicity associations[J].Neurotoxicol Teratol,2014,42:85-92.
[3] Strain JJ,Davidson PW,Bonham MP,et al.Associations of maternal long-chain polyunsaturated fatty acids,methyl mercury,and infant development in the Seychelles Child Development Nutrition Study[J].NeuroToxicology,2008,29(5):776-782.
[4] Raymond LJ,Ralston N.Selenium's importance in regulatory issues regarding mercury[J].Fuel Process Technol,2009,90(11):1333-1338.
[5] Davidson PW,Myers GJ,Cox C,et al.Effects of prenatal and postnatal methylmercury exposure from fish consumption on neurodevelopment:outcomes at 66 months of age in the Seychelles Child Development Study[J].JAMA,1998,280(8):701-707.
[6] Hibbeln JR,Davis JM,Steer C,et al.Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC study):an observational cohort study[J].Lancet,2007,369(9561):578-585.
[7] Choi AL,Budtz-Jorgensen E,Jorgensen PJ,et al.Selenium as a potential protective factor against mercury developmental neurotoxicity[J].Environ Res,2008,107(1):45-52.
[8] Saint-Amour D,Roy MS,Bastien C,et al.Alterations of visual evoked potentials in preschool Inuit children exposed to methylmercury and polychlorinated biphenyls from a marine diet[J].Neurotoxicology,2006,27(4):567-578.
[9] Despres C,Beuter A,Richer F,et al.Neuromotor functions in Inuit preschool children exposed to Pb,PCBs,and Hg[J].Neurotoxicol Teratol,2005,27(2):245-257.
[10] Jacobson JL,Muckle G,Ayotte P,et al.Relation of prenatal methylmercury exposure from environmental sources to childhood IQ[J].Environ Health Perspect,2015,123(8):827-833.
[11] Farina M,Rocha JB,Aschner M.Mechanisms of methylmercury-induced neurotoxicity:evidence from experimental studies[J].Life Sci,2011,89(15-16):555-563.
[12] Sakamoto M,Yasutake A,Kakita A,et al.Selenomethionine protects against neuronal degeneration by methylmercury in the developing rat cerebrum[J].Environ Sci Technol,2013,47(6):2862-2868.
[13] Glaser V,Nazari EM,Muller YM,et al.Effects of inorganic selenium administration in methylmercury-induced neurotoxicity in mouse cerebral cortex[J].Int J Dev Neurosci,2010,28(7):631-637.
[14] Kaur P,Evje L,Aschner M,et al.The in vitro effects of selenomethionine on methylmercury-induced neurotoxicity[J].Toxicol In Vitro,2009,23(3):378-385.
[15] Yin ZB,Lee E,Ni MW,et al.Methylmercury-induced alterations in astrocyte functions are attenuated by ebselen[J].Neurotoxicology,2011,32(3):291-299.
[16] Funchal C,Moretto MB,Vivian L,et al.Diphenyl ditelluride- and methylmercury-induced hyperphosphorilation of the high molecular weight neurofilament subunit is prevented by organoselenium compounds in cerebral cortex of young rats[J].Toxicology,2006,222(1-2):143-153.
[17] Moretto MB,Funchal C,Zeni G,et al.Selenium compounds prevent the effects of methylmercury on the in vitro phosphorylation of cytoskeletal proteins in cerebral cortex of young rats[J].Toxicol Sci,2005,85(1):639-646.
[18] Jayashankar S,Glover CN,Folven KI,et al.Cerebral gene expression in response to single or combined gestational exposure to methylmercury and selenium through the maternal diet[J].Cell Biol Toxicol,2011,27(3):181-197.
[19] Branco V,Canario J,Lu J,et al.Mercury and selenium interaction in vivo:effects on thioredoxin reductase and glutathione peroxidase[J].Free Radic Biol Med,2012,52(4):781-793.
[20] Paletz EM,Craig-Schmidt MC,Newland MC.Gestational exposure to methylmercury and n-3 fatty acids:effects on high- and low-rate operant behavior in adulthood[J].Neurotoxicol Teratol,2006,28(1):59-73.
[21] Newland MC,Hoffman DJ,Heath JC,et al.Response inhibition is impaired by developmental methylmercury exposure:acquisition of low-rate lever-pressing[J].Behav Brain Res,2013,253:196-205.
[22] Davidson PW,Strain JJ,Myers GJ,et al.Neurodevelopmental effects of maternal nutritional status and exposure to methylmercury from eating fish during pregnancy[J].Neurotoxicology,2008,29(5):767-775.
[23] Stokes-Riner A,Thurston SW,Myers GJ,et al.A longitudinal analysis of prenatal exposure to methylmercury and fatty acids in the Seychelles[J].Neurotoxicol Teratol,2011,33(2):325-328.
[24] Lynch ML,Huang LS,Cox C,et al.Varying coefficient function models to explore interactions between maternal nutritional status and prenatal methylmercury toxicity in the Seychelles Child Development Nutrition Study[J].Environ Res,2011,111(1):75-80.
[25] Strain JJ,Davidson PW,Thurston SW,et al.Maternal PUFA status but not prenatal methylmercury exposure is associated with children's language functions at age five years in the Seychelles[J].J Nutr,2012,142(11):1943-1949.
[26] Boucher O,Burden MJ,Muckle G,et al.Neurophysiologic and neurobehavioral evidence of beneficial effects of prenatal omega-3 fatty acid intake on memory function at school age[J].Am J Clin Nutr,2011,93(5):1025-1037.
[27] Vacchi-Suzzi C,Karimi R,Kruse D,et al.Low-level mercury,omega-3 index and neurobehavioral outcomes in an adult US coastal population[J].Eur J Nutr,2015.Doi:10.1007/s00394-015-0890-5.
[28] Kaur P,Heggland I,Aschner M,et al.Docosahexaenoic acid may act as a neuroprotector for methylmercury-induced neurotoxicity in primary neural cell cultures[J].Neurotoxicology,2008,29(6):978-987.
[29] Kaur P,Schulz K,Aschner M,et al.Role of docosahexaenoic acid in modulating methylmercury-induced neurotoxicity[J].Toxicol Sci,2007,100(2):423-432.
[30] Grotto D,Vicentini J,Angeli JP,et al.Evaluation of protective effects of fish oil against oxidative damage in rats exposed to methylmercury[J].Ecotoxicol Environ Saf,2011,74(3):487-493.
[31] Jayashankar S,Glover CN,Folven KI,et al.Cerebral gene expression and neurobehavioural responses in mice pups exposed to methylmercury and docosahexaenoic acid through the maternal diet[J].Environ Toxicol Pharmacol,2012,33(1):26-38.
[32] Yavin E,Himovichi E,Eilam R.Delayed cell migration in the developing rat brain following maternal omega 3 alpha linolenic acid dietary deficiency[J].Neuroscience,2009,162(4):1011-1022.
[33] Paletz EM,Day JJ,Craig-Schmidt MC,et al.Spatial and visual discrimination reversals in adult and geriatric rats exposed during gestation to methylmercury and n-3 polyunsaturated fatty acids[J].Neurotoxicology,2007,28(4):707-719.