目的 研究孕母妊娠高血压对早产儿结局的影响,为临床诊疗提供科学依据。方法 选择2015年1-12月在聊城市人民医院出生入住本院新生儿监护室的妊娠高血压孕母娩出的早产儿112例为观察组,同期由于胎儿窘迫等因素分娩早产儿102例为对照组,分析完整的临床资料,比较两组患儿一般资料、白细胞、血红蛋白、血小板、凝血功能、相关并发症等资料。结果 两组新生儿胎龄、低出生体重儿比例差异有统计学意义,观察组产前异常(宫内窘迫、羊水污染)以及生后合并败血症例数多,白细胞、血小板以及中性粒细胞数均低于对照组,而血红蛋白明显高于对照组;凝血功能中凝血酶原时间(PT),活化部分凝血活化酶时间(APTT)明显高于对照组,观察组需呼吸支持时间以及用氧时间长于对照组,视网膜病变、坏死性小肠结肠炎、颅内出血发病率高于对照组;观察组的新生儿神经行为评分明显低于对照组,以上各组间比较差异均有统计学意义(P<0.05)。结论 母亲妊娠高血压可造成胎儿宫内生长发育迟缓,所产的早产儿易合并白细胞、中性粒细胞绝对值(ANC)、血小板减少及凝血功能障碍,并容易引起感染、败血症,合并症以及后遗症发病率高。
Abstract
Objective To investigate the effect of gestational hypertension on the outcome of premature infants,and to provide a scientific basis for clinical diagnosis and treatment.Methods Totally 112 cases admitted to NICU were enrolled in observation group from January to December 2015.Meanwhile,a total of 102 cases with fetal distress premature were selected as the control group.Complete clinical data including the general data,white blood cells,hemoglobin,platelet,coagulation function,related complications and other data were collected and compared between two groups.Results In observation group,the gestational age and the ratio of low birth weight newborn were lower and the difference was significant.There were difference between gestational age and the ratio of were not statistical.In observation group,antenatal abnormalities (intrauterine distress,amniotic fluid pollution) and sepsis cases after birth were significantly higher.In observation group,the levels of white blood cells,platelets,and number of neutrophils were lower than control group and PT,APTT were higher than control group.In observation group,the respiratoy support time and oxygen time were significantly longer than in control group.And the incidence of retinopathy of prematurity (ROP),necrotizing enterocolitis (NEC) and intracranial hemorrhage(IVH) was higher which difference were significant.The NBNA in the observation group were significantly lower than those in the control group (P<0.05).Conclusions Gestational hypertension may cause fetal intrauterine growth restriction.Pretmature infants born to gestational hypertension mothers are prone to high incidence of leukocytopenia,neutroperia,coagulation disorder,infection,sepsis,comorbidity and sequela.
关键词
妊娠高血压 /
早产儿 /
结局
Key words
gestational hypertension /
premature infant /
neonatal outcome
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参考文献
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基金
山东省医药卫生科技发展计划项目(2014WS0044)
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