目的 探讨2～3岁孤独症谱系障碍(ASD)儿童和正常儿童间叫名反应的客观量化的指标差异。方法 纳入2016年5-8月在中山大学附属第三医院儿童发育行为中心确诊的2～3岁ASD儿童22名,正常儿童21名。在多模态实验室中进行标准流程叫名反应,通过评估师打分和计算机自动分析系统分析在正常情景反应下两组儿童的叫名反应的特征和差异。结果 1)ASD组与正常组儿童的叫名反应评分比较,差异有统计学意义(Z=15.764,P＜0.01)。2)对比计算机自动分析叫名反应的反应时间和持续时间,ASD和正常组在反应时间上的差异无统计学意义(Z=-1.593,P=0.113),ASD的持续时间短于正常组儿童,差异有统计学意义(Z=-3.4,P=0.001)。结论 2~3岁ASD儿童的叫名反应差于正常儿童,ASD儿童早期叫名反应的异常症状表现为目光对视更少和持续时间更短。
Abstract
Objective To explore the objectivity differences of responses to name between autism spectrum disorder (ASD) and children with normal development.Method A total of 22 ASD children diagnosed in Children Development & Behavioral Center of the Third Affiliated Hospital of SUN Yat-sen University from May to August in 2016 and 21 controls was enrolled in this study.In standard procedure testing the response to name.After that,two professional evaluators scored the response to name,and automatic system computational analyzed the time of response to name and duration to response.Result 1)There were no significant differences in scores of response to name between ASD children and normal children (Z=15.764,P＜0.01).2)The computational analysis showed that in response to name procedure,the response time showed no differences in ASD group and control group (Z=-1.593,P=0.113),But response duration was shorter in ASD group than that in control group(Z=-3.4,P=0.001).Conclusions Compared to normal children,2~3-year-old children with ASD have inferior behavior in response to name.The characteristics of abnormal response to name in ASD children include less eye contact and shorter response duration.
关键词
叫名反应 /
孤独症谱系障碍 /
客观化
Key words
responses to name /
autism spectrum disorder /
objectivity
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参考文献
[1] Wan MW,Green J,Elsabbagh M,et al.Quality of interaction between at risk infants and caregiver at 12-15 months is associated with 3-year autism outcome[J].Journal of Child Psychology and Psychiatry,2013,7:763-771.
[2] Dawson G,Toth K,Abbott R,et al.Early social attention impairments in autism:social orienting,joint attention,and attention to distress[J].Developmental Psychology,2004,40(2):271-283.
[3] Chawarska K,Macari S,Powell K,et al.Enhanced social attention in female infant siblings at risk for autism[J].Journal of the American Academy of Child & Adolescent Psychiatry,2015,55(3):188-195.
[4] Abruzzo PM,Ghezzo A,Bolotta A,et al.Perspective biological markers for autism spectrum disorders:Advantages of the use of receiver operating characteristic curves in evaluating marker sensitivity and specificity[J].Disease Markers,2015,329607.doi:10.1155/2015/329607
[5] 王吉,梁亚勇,唐春,等.婴幼儿孤独症的早期预警信号[J].中国儿童保健杂志,2017,25(3):234-237.
[6] Bidwell J,Essa IA,Rozga A,et al.Measuring child visual attention using markerless head tracking from color and depth sensing cameras[M].//Proceedings of the 16th International Conference on Multimodal Interaction-ICMI'14.New York,USA:ACM Press,2014:447-454.
[7] Lord C,Risi S,Lambrecht L,et al.The Autism Diagnostic Schedule - Generic:A standard measures of social and communication deficits associated with the spectrum of autism[J].Journal of Autism and Developmental Disorders,2000,30(3):205-223.
[8] Kondolot M,zmert EN,ztop DB,et al.The modified checklist for autism in Turkish toddlers:A different cultural adaptation sample[J].Research in Autism Spectrum Disorders,2016,21:121-127.
[9] De Giacomo A,Craig F,Cristella A,et al.Can PEP-3 provide a cognitive profile in children with ASD? A comparison between the developmental ages of PEP-3 and IQ of Leiter-R[J].Journal of Applied Research in Intellectual Disabilities,2016,29(6):566-573.
[10] Nadig AS,Ozonoff S,Young GS,et al.A prospective study of response to name in infants at risk for autism[J].Archives of Pediatrics & Adolescent Medicine,2007,161(4):378-383.
[11] Ozonoff S,Iosif AM,Baguio F,et al.A prospective study of the emergence of early behavioral signs of autism[J].Journal of the American Academy of Child & Adolescent Psychiatry,2010,49(3):256-266.
[12] Gabrielsen TP,Farley M,Speer L,et al.Identifying autism in a brief observation[J].Pediatrics,2015,135(2):e330-e338.
[13] Zappella M,Einspieler C,Bartl-Pokorny KD,et al.What do home videos tell us about early motor and socio-communicative behaviours in children with autistic features during the second year of life-An exploratory study[J].Early Human Development,2015,91(10):569-575.
[14] Palomo R,Carmona MB,Ozonoff S.Autism and family home movies:A comprehensive review[J].Journal of Developmental and Behavioral Pediatrics,2006,27(Suppl 2):59-68.
[15] Chawarska K,Macari S,Shic F.Decreased spontaneous attention to social scenes in[J].Biological Psychiatry,2013,74(3):195-203.
[16] Chawarska K,Ye S,Shic F,et al.Multilevel differences in spontaneous social attention in toddlers with autism spectrum disorder[J].Child Development,2016,87(2):543-557.
[17] Chita-Tegmark M.Social attention in ASD:A review and meta-analysis of eye-tracking studies[J].Research in Developmental Disabilities,2015,48:79-93.
[18] Thorup E,Nystr m P,Gredeb ck G,et al.Altered gaze following during live interaction in infants at risk for autism:an eye tracking study[J].Molecular Autism,2016,7(1):12.
[19] Muskett T,Body R,Muskett TOM,et al.The case for multimodal analysis of atypical interaction:Questions,answers and gaze in play involving a child with autism[J].Clinical Linguistics & Phonetics,2013,27(10-11):837.
[20] Fusaro VA,Daniels J,Duda M,et al.The potential of accelerating early detection of autism through content analysis of youtube videos[J].PLoS ONE,2014,9(4):1-6.
基金
国家重点基础研究发展计划 (973计划)项目 (2012CB517901)
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