目的 分析新疆维吾尔族儿童脑瘫发生的危险因素,为脑瘫的预防和治疗提供临床依据。方法 收集2013年1月-2015年6月新疆自治区人民医院收治的0~6岁维吾尔族脑瘫患儿286例,与相同年龄段的维吾尔族健康儿童572名作比较,应用单因素和多因素Logistic回归分析脑瘫发生的危险因素。结果 单因素Logistic分析显示:影响脑瘫发生涉及遗传因素、产前、产时和产后的多种因素。多因素Logistic回归分析得出该种族儿童脑瘫的危险因素主要有近亲结婚、脑病家族史、母孕期感染、母不良孕产史、胎龄<32周、宫内窘迫、低出生体重、新生儿窒息、新生儿重度黄疸、新生儿缺氧缺血性脑病。结论 新疆维吾尔族儿童脑瘫的发生涉及多种危险因素,应积极加强对各危险因素的预防和干预工作,以降低儿童脑瘫的发生率。
Abstract
Objective To analyze the risk factors in Uighur children with cerebral palsy (CP) in Xinjiang,and to provide clinical evidence to the prevention and treatment of CP.Methods A total of 286 Uighur children with CP and 572 healthy Uighur children (0~6 years old) were collected from Xinjiang autonomous region people's hospital during Jan.2013 to Jun.2015.The risk factors of CP was analyzed by single factor and multiple-factor logistic analysis method.Results Single factor logistic analysis showed that the incidence of CP correlated with genetic factor and various antenatal,intrapartum and postpartum factors.Multiple-factor logistic analysis showed that the risk factors of CP mainly contained intermarriage,family history of encephalopathy,pregnant infection,negative reproductive history,gestational age <32 weeks,fetal distress,low birth weight,neonatal asphyxia,neonatal severe jaundice and newborn hypoxia ischemia.Conclusions The incidence of CP for Xinjiang Uighur children is related to multiple risk factors,the prevention and intervention of each risk factors should be strengthened to reduce the incidence of CP in children.
关键词
脑性瘫痪 /
危险因素 /
儿童
Key words
cerebral palsy /
risk factor /
children
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参考文献
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基金
国家自然科学基金资助项目(81270665);安徽省教育厅重点项目(2011kj091A)
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