目的 研究儿童心肺运动试验(CPET)生理指标及其变化规律,以期建立儿童心肺运动试验正常参考值范围。方法 采用心肺运动测试系统按照标准CPET方案对450例健康儿童进行心肺运动试验,每1自然岁50例,男女各半。检测指标包括无氧阈(VO2@AT)、峰值摄氧量(VO2峰值)、峰值氧脉搏(峰值VO2/HR)、二氧化碳通气当量最低值(VE/VCO2最低值)、二氧化碳通气当量斜率(VE/VCO2 slope)、摄氧效率斜率(OUES)、峰值负荷功率(Pmax)、峰值心率(HRmax)和最大分钟通气量(VEmax)。结果 男童VO2峰值为:4~6岁:(816.36±152.03)ml/min;7~9岁:(1 132.19±261.6)ml/min;10~12岁:(1 418.99±270.2)ml/min。女童VO2峰值为:4~6岁:(700.36±139.77)ml/min;7~9岁:(1 004.19±198.5)ml/min;10~12岁:(1 264.97±230.2)ml/min。VO2@AT、VO2峰值、峰值VO2/HR、OUES、Pmax和VEmax均随年龄增长而增加(P均<0.001),而VE/VCO2最低值及VE/VCO2 slope随年龄增长而降低(P均<0.001)。并建立了各核心指标正常预计值公式,其中峰值VO2/HR=-2.757+0.148×年龄(y)+0.049×身高(cm)+0.040×体重(kg)+0.892×性别(“男”=1,“女”=0)。结论 本研究是针对国内儿童心肺运动试验医学参考值的较大样本研究,在国内无儿童心肺运动试验医学参考值判断标准的情况下,可以参考本项研究结果。
Abstract
Objective To study the physiological indexes of children receiving cardiopulmonary exercise testing(CPET)in order to establish the normal CPET reference value in Chinese children. Methods Four hundred and fifty healthy children underwent the CPET with the standard scheme using the cardiopulmonary testing system.There were fifty children per age,and the gender ratio was 1∶1.The indexes included oxygen uptake at anaerobic threshold (VO2@AT),peak oxygen uptake (VO2 peak),peak oxygen pulse (peak VO2/HR),minimum of respiratory minute volume to CO2 production (VE/VCO2 minimum),slope of respiratory minute volume to CO2 production (VE/VCO2 slope),slope of oxygen uptake efficiency (OUES),peak tolerance power (Pmax),peak heart rate (HRmax) and maximal minute ventilation(VEmax). Results The VO2 peak of boys was:4~6 years old:(816.36±152.03)ml/min;7~9 years old:(1 132.19±261.6)ml/min;10~12 years old:(1 418.99±270.2)ml/min respectively.The VO2 peak of girls was:4~6:(700.36±139.77)ml/min;7~9 years old:(1 004.19±198.5)ml/min;10~12:(1 264.97±230.2)ml/min.VO2@AT,VO2 peak,Peak VO2/HR,OUES,Pmax and VEmax all increased with age (P<0.001).VE/VCO2 minimum and VE/VCO2 slope decreased with age(P<0.001).The prediction equations for the above indexes were established by parameters of anthropometry.Peak VO2/HR=-2.757+0.148×age (y) +0.049 × height (cm) +0.040× weight (kg) +0.892 × gender ("boys" =1,"girls" =0). Conclusions This study is to provide CPET medical reference value based on a large sample of Chinese children.The study can be used under the circumstances that there is no pediatric medical reference of CPET in China.
关键词
心肺运动试验 /
儿童 /
生理指标 /
医学参考值
Key words
cardiopulmonary exercise testing /
children /
physiological index /
medical reference values
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