目的 研究血清1,25-(OH)D3水平和总IgE水平在喘息婴幼儿中的表达及临床意义。方法 随机选取2015年9月-2016年3月于本院住院的喘息患儿52例,依据哮喘预测指数分为哮喘预测指数阳性的喘息Ⅰ组(n=29)和哮喘预测指数阴性的喘息Ⅱ组(n=23),对照组为本院门诊健康体检儿童(n=23)。分别测定3组患儿血清1,25-(OH)D3和总IgE水平。结果 喘息Ⅰ组和喘息Ⅱ组患儿血清1,25-(OH)D3水平均低于对照组,差异有统计学意义(P<0.05),喘息Ⅰ组1,25-(OH)D3水平低于喘息Ⅱ组(P<0.05),喘息Ⅰ组IgE水平高于喘息Ⅱ组和对照组,差异有统计学意义(P<0.05),喘息Ⅱ组和对照组之间差异无统计学意义(P>0.05);喘息Ⅰ组血清1,25-(OH)D3与IgE呈负相关性(r=-0.915,P<0.01)。结论 1,25-(OH)D3水平在有特应质的反复喘息儿童中显著降低,并且与总IgE水平呈负相关。
Abstract
Objective To explore the expression and clinical significance of 1,25-(OH)D3 and IgE in wheezing infants and young children. Methods Children with recurrent wheezing children had been randomly enrolled from September 2015 to March 2016 in our hospital.According to the asthma predictive index,they were divided into 2 groups:wheezing group Ⅰ with positive predictive index(n=29)and wheezing group Ⅱ with negative predictive index(n=23).The healthy children had been enrolled randomly as normal control group(n=23).The serum level of 1,25-(OH)D3 and the IgE was measured. Results The serum levels of 1,25-(OH)D3 in wheezing groups were lower than those of normal control group,the levels of 1,25-(OH)D3 in group Ⅰ were lower than the group Ⅱ,the difference was statistically significant (P<0.05);The level of IgE in wheezing groupⅠwas significantly higher than those in wheezing group Ⅱand the control group (P<0.05),while wheezing group Ⅱ group and the control group had no significant difference (P>0.05);There was remarkably negative correlation between vitamin D and IgE in group Ⅰ(r=-0.915,P<0.01). Conclusion The level of 1,25-(OH)D3 is significantly decline in recurrent wheezing children with atopic,and there is remarkably negative correlation between the serum levels of 1,25-(OH)D3 and IgE in wheeze children with atopic.
关键词
喘息 /
1,25-(OH)D3 /
婴幼儿
Key words
wheezing /
1,25-(OH)D3 /
child
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
[1] Aranda C,Wandalsen G,Fonzar L,et al.Risk factors for recurrent wheezing-international study of wheezing in infants (EISL) phase 3[J].World Allergy Organization Journal December,2015,8:123.
[2] 李亚琴,薛海燕,陈伟,等.按哮喘预测指数分组治疗在5 岁以下喘息儿童中的应用[J].中国当代儿科杂志,2014,16(8):795-799.
[3] Adams JS,Liu PT,Chun R,et al.Vitamin D in defense of the human immune response[J].Ann N Y Acad Sci,2007,1117:94-105.
[4] Bener A,Ehlayel MS,Bener HZ,et al.The impact of Vitamin D deficiency on asthma,allergic rhinitis and wheezing in children:An emerging public health problem[J].J Family Community Med,2014,21(3):154-61.
[5] 王福文.维生素D与儿童疾病新进展[J].中国临床研究,2011,24(9):840-841.
[6] Moreno-Solís G.Low serum 25-hydroxyvitamin D levels and bronchiolitis severity in Spanish infants[J].European Journal of Pediatrics,2015,174(3):365-372.
[7] 麦长远.1,25-(OH)D 3 缺乏与毛细支气管炎发病的关系[J].中国实用医药,2014,9(10):91-93.
[8] Camargo CA,Ingham TJ,Wickens K,et al.Cord-blood 25-hydroxyvitamin D levels and risk of respiratory infection wheezing and asthma[J].Pediatrics,2011,127(1):180-187.
[9] Uysalol M,Mutlu LC,Saracoglu GV,et al.Childhood asthma and vitamin D deficiency in Turkey:is there cause and effect relationship between them [J].Italian Journal of Pediatrics December,2013,39:78.
[10] 胡婉珊,黄蔚,陈瑞琦.维生素 D 缺乏与小儿支气管哮喘相关性探讨[J].辽宁医学院学报,2016,37(2):61-63.
[11] Hammar KS,Hedlin G,Konradsen JR,et al.Subnormal levels of vitamin D are associated with acute wheeze in young children[J].Acta Paediatr,2014,103(8):856-861.
PDF(450 KB)
