目的 分析反复性喘息婴幼儿血清25-羟基维生素D[25(OH)D]水平与哮喘预测指数(API)的关系,为喘息婴幼儿的预后进行准确的预测提供依据。方法 选取2014年10月-2016年09月在深圳市妇幼保健院儿科就诊的反复性(≥3次发作)喘息婴幼儿作为研究对象。根据API将其分为API阳性组和API阴性组,以常规体检正常婴幼儿作为对照组,比较三组婴幼儿25(OH)D和总IgE水平差异,采用Pearson相关分析判断25(OH)D水平与总IgE水平的相关性。结果 API阳性组25(OH)D的平均水平为(18.97±4.98)ng /ml最低,其次为API阴性组为(23.05±6.32)ng/ml,均低于对照组( 27.67±6.82)ng/ml,差异有统计学意义(P<0.05)。API阳性组总IgE的平均水平[(192.83±32.36)IU/ml]最高,其次为API阴性组为(109.45±12.51)IU/ml,均高于对照组(99.42±18.64)IU/ml,差异有统计学意义(P<0.05)。API阳性组25(OH)D缺乏的发生率(45.71%),高于API阴性组(23.94%)和对照组(17.50%),差异有统计学意义(P<0.05)。Pearson相关分析显示API阳性组喘息婴幼儿的维生素D水平与IgE水平呈负相关性(r=-0.727,P<0.05)。结论 在反复性喘息婴幼儿中存在25(OH)D水平降低,且其与API阳性喘息婴幼儿的总IgE水平呈负相关。维生素D缺乏可能在反复性喘息婴儿的发病机理中起作用,并可能为一个评估其转为哮喘的风险的指标。
Abstract
Objective To investigate the correlation of 25-hydroxy vitamin D[25 (OH)D] level and asthma predicting index (API),and to provide a basis for accurately predicting of the prognosis in infants with recurrent wheezing. Methods The study group consisted of infants with recurrent wheezing which were followed by Pediatrics in Shenzhen Maternity and Child Healthcare Hospital from October 2014 to September 2016.25 (OH)D and total IgE were examined in the participants.The patients were classified into two groups according to API positivity and compared to control subjects(40 normal infants)regarding their 25 (OH)D level and total IgE level.The correlation between API and the level of 25 (OH)D was carried on Pearson correlation analysis. Results The API positive group had the lowest means 25 (OH)D level[(18.97±4.98)ng/ml] followed by API negative group[(23.05±6.32)ng/ml] compared to control group[(27.67±6.82)ng/ml](P<0.05).The API positive group had the highest means IgE level[(192.83±32.36)IU/ml] followed by API negative group[(109.45±12.51)IU/ml] compared to control group[(99.42±18.64)IU/ml] (P<0.05).The incidence of vitamin D deficiency in infants in API positive group (45.71%) is higher than API negative group (23.94%)and control group (17.50%)(P<0.05).There was a negative correlation between the level of total IgE and the level of vitamin D in API positive group(r=-0.727,P<0.05). Conclusions Low level of 25 (OH)D are detected in infants with recurrent wheezing.The 25 (OH)D level is negatively correlated with the levels of total IgE in recurrent wheezing infants with API positive.Vitamin D deficiency may play a role in the pathogenesis of infants with recurrent wheezing,and may be an indicator for assessing the risk of their conversion to asthma.
关键词
维生素D /
哮喘预测指数 /
反复性喘息 /
婴幼儿
Key words
vitamin D /
asthma predicting index /
recurrent wheezing /
infant
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