目的 研究北京地区0~6月龄母乳喂养儿的维生素D水平变化及与相关指标BAP、PTH的关系,为今后的婴儿保健工作提供数据支持。方法 选取健康新生儿,生后予规律补充维生素D400 IU/d至6月龄,在0、4、6月龄分别取静脉血检测维生素D及BAP、PTH的水平,评估北京地区母乳喂养儿维生素D的现状及各指标之间的关系。结果 0月龄组婴儿维生素D正常与良好的人数仅占28.8%, 经过规律补充维生素D,4月龄组此比值为82.8%,6月龄组为83%。0月龄组25-(OH)D3水平与4月龄组呈显著正相关关系(r=0.481,P＜0.01),4月龄组BAP及PTH均与血25-(OH)D3水平呈负相关关系(r=-0.485和-0.216,P＜0.05)。结论 北京地区新生儿血维生素D水平较低,经过规律补充维生素D大部分婴儿可达正常水平,婴儿出生时25-(OH)D3储备可能对婴儿早期25-(OH)D3水平产生一定的影响。
Abstract
Objective To investigate vitamin D status of 0~6 month-old breastfeeding infants in Beijing area and the relationships between 25(OH)D,PTH and BAP. Methods Mother-infant pairs were recruited.All breastfed infants receive a daily vitamin D supplement of 400 IU.Venous blood was collected and the levels of serum 25(OH)D,PTH and BAP were also measured when infants were born and 4 months and 6 months of age. Results At 0 month group,only a small part of infants whose (28.8%) vitamin D level were in normal range,and the proportion rose to 82.8% when they were 4 months old,and 83% at 6 months of age.There was a significantly positively correlation of serum 25(OH)D between 0 month group and 4 months group (r=0.418,P＜0.01).At 4 months group,serum 25(OH)D was inversely correlated with both BAP and PTH (r=-0.485 and -0.216,P＜0.05). Conclusions Vitamin D status of newborn in Beijing is low,but most of breastfeeding infants can have a good vitamin D status through a daily vitamin D supplement of 400 IU.Neonatal vitamin D reserves may affect the vitamin D levels of their early days.
关键词
维生素D缺乏 /
母乳喂养儿 /
维生素D供给 /
甲状旁腺素 /
骨碱性磷酸酶
Key words
vitamin D deficiency /
breastfed infants /
vitamin D supplement /
parathyroid hormone /
bone alkaline phosphatase
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