20世纪90年代 Barker DJ提出健康与疾病发育起源的学说,越来越多的流行病学调查及动物实验提示母亲孕期营养对其子代成年以后非感染性疾病(代谢性综合征及心肺疾病等)的发生有着重要的联系。而也有一些调查研究发现母亲孕期营养可能引起子代成年时期非感染性疾病,还可能影响子代儿童时期非感染性疾病的发生,如儿童哮喘,喘息,遗传性过敏体质等。这些疾病带给患儿心理负担,严重影响患儿生长发育、生活质量并伴有生命危险。然而大量的研究提示孕期合理营养,科学膳食可以降低子代这些疾病的发病风险。我国目前生活质量提高,现如今多数孕妇营养摄入不平衡,或处饱和甚至过剩状态,而儿童过敏性疾病的发生逐年增加。本文就孕期营养对子代儿童期哮喘,喘息及遗传性过敏性体质发生的影响做一简要的综述。
Abstract
More and more epidemiological investigation and animal experiment indicated that the maternal nutrition has associated with the risk of developing adult offspring's non-infectious diseases in later life.These findings showed that the unbalanced maternal nutrition not only arouses their adult offspring non-infectious diseases,but also influences the risk of developing their offspring's asthma,gasp,and hereditary allergic constitution in childhood.These diseases will bring about psychological burden to the children,and seriously influence their growth,development and living quality,accompanied with life danger.However,many researches indicated that the rational nutrition and scientific diet during the pregnancy can reduce the morbidity risk of these diseases of the offspring.This paper makes simple summary for the effects of maternal nutrition on asthma,wheeze,and hereditary allergic diseases outcome in offspring during childhood.
关键词
儿童期 /
哮喘 /
喘息 /
遗传性过敏体质 /
孕期 /
营养
Key words
childhood /
asthma /
wheeze /
allergic /
maternal /
nutrition
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参考文献
[1] 金岩,张丽颖.国内儿童哮喘流行病学调查的回归分析[J].中华中医药学刊,2012,30(6):1399-1401.
[2] Bierbaum S,Heinzmann A.The genetics of bronchial asthma in children.[J].Respiratory Medicine,2007,101(7):1369-1375.
[3] 王玉霞,朱伟杰.环境有害因素对胎儿发育的损伤[J].生殖与避孕,2012,32(12):837-843.
[4] 刘冬英,王林静,王秀霞,等.广州市孕妇营养知识、态度及饮食行为调查[J].现代预防医学,2007,34(14):2683-2685.
[5] 王宏,范岩峰,蔡李倩,等.孕期营养评价及干预措施对妊娠结局的影响[J].中国妇幼保健,2010,25(12):1609-1614.
[6] 汪雅.成都片区0~14岁儿童哮喘的先天禀赋因素分析[D].成都:成都中医药大学,2012.
[7] 袁雪晶,许慧洁.母亲孕期饮食与哮喘患儿婴幼儿期反复喘息的相关性研究[J].中华中医药杂志,2015,30(7):2360-2363.
[8] 安淑华,王艳艳,宋庆,等.儿童哮喘相关因素 Logistic 回归分析[J].临床儿科杂志,2010,28(5):455-458.
[9] Andreasyan K,Ponsonby AL,Dwyer T,et al.A differing pattern of association between dietary fish and allergenspecific subgroups of atopy [J].Allergy,2005,60(5):671-677.
[10] Morales E.Maternal vitamin D status in pregnancy and risk of lower respiratory tract infections,wheezing,and asthma in offspring[J].Epidemiology,2012,23(1):64-71.
[11] Hammond CM,White D,Tomic J,et al.Extracellular calcium sensing promotes human B-cell activation and function [J].Blood,2007,110 (12):3985-3995.
[12] Devereux G.The increase in the prevalence of asthma and allergy:food for thought[J].Nature Rev Immunol,2006,6(11):869-874.
[13] Zosky GR,Berry LJ,Elliot JG,et al.Vitamin D deficiency causes deficits in lung function and alters lung structure[J].Am J Respir Crit Care Med,2011,183(10):1336-1343.
[14] Camargo CA,Rifas-Shiman SL,Litonjua AA,et al.Maternal intake of Vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age[J].American Journal of Clinical Nutrition,2007,85(3):788-795.
[15] Beckhaus AA,Garcia-Marcos L,Forno E,et al.Maternal nutrition during pregnancy and risk of asthma,wheeze,and atopic diseases during childhood:a systematic review and meta-analysis[J].Allergy,2015,70(12):1588-1604.
[16] 周建烈,沈艳杰.孕妇维生素D需要量和补充量的研究进展[J].中华临床营养杂志,2011,19(6):424-428.
[17] 毛丽梅.孕妇长链多不饱和脂肪酸水平与胎儿生长发育及其免疫功能的关系[C].中国营养学会第九届营养科研基金2014年度DSM专项科研基金发布会暨学术研讨会资料汇编,2014.
[18] Fumhjelm C,Warstedt K,Larsson J,et a1.Fish oil supple mentation in pregnancy and lactation may decrease the risk of infant allergy[J].Aeta Paodiatr,2009,98(9):1461-1467.
[19] 闫慧.微量元素锌对婴幼儿毛细支气管炎后反复喘息的影响[J].微量元素与健康研究,2015,32(3):86-86.
[20] 胡雨生,徐巧岚,杨代秀,等.血微、常量元素水平与儿童支气管哮喘的相关性研究[J].中国儿童保健杂志,2012,20(9):838-840.
[21] 王容,凡伟,黎春梅,等.胎儿生长受限与母血、脐血中锌含量的相关性研究[J].中国妇幼保健,2015,30(23):3978-3979.
[22] 王娟.孕期添加益生菌预防新生儿过敏性疾病的疗效观察[J].右江医学,2013,41(5):674-676.
[23] Rautava S,Kainonen E,Salminen S,et al.Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant[J].J Allergy Clin Immunol,2012,130(6):1355-1360.
[24] 刘明颖,李辉,施展,等.晚孕期孕妇口服益生菌制剂对新生儿肠道菌群及脐血IL-4、IFN-γ水平影响的临床研究[J].中国妇幼保健,2012,27(6):923-925.
[25] Ekstrm S,Magnusson J,Kull I,et al.Maternal BMI in early pregnancy and offspring asthma,rhinitis and eczema up to 16 years of age[J].Clinical & Experimental Allergy,2015,45(1):283-291.
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