儿童空气污染暴露与CC16相关研究进展

史航; 朱运; 吕雪峰; 何钦成; 马亚楠

doi:10.11852/zgetbjzz2017-25-02-12

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中国儿童保健杂志 ›› 2017, Vol. 25 ›› Issue (2) : 151-153. DOI: 10.11852/zgetbjzz2017-25-02-12

综述与讲座

儿童空气污染暴露与CC16相关研究进展

史航¹,朱运²,吕雪峰³,何钦成⁴,马亚楠⁴

作者信息 +

Advances in research on children's exposure to air pollution and CC16

SHI Hang¹,ZHU Yun²,LV Xue-feng³,HE Qin-cheng⁴,MA Ya-nan⁴

Author information +

文章历史 +

摘要

随着现代社会的迅猛发展,空气污染加剧,引起了一系列呼吸系统疾病,受到人们广泛关注。肺部疾病的生物标记物Clara细胞分泌蛋白(CC16)主要是由分布在呼吸道的Clara细胞分泌产生,有保护气道的作用。近年来研究表明室内外空气污染暴露可能会影响CC16水平,但具体机制尚不完全清楚。本文从室内外空气污染暴露与儿童CC16关系以及空气污染影响CC16的机制等方面进行综述。

Abstract

With the rapid development of modern society,a series of respiratory diseases caused by air pollution have been widely concerned.Clara cell secretory protein (CC16),a biomarker of lung disease,is mainly produced by the secretion of Clara cells in the respiratory tract.In recent years,the study show that indoor and outdoor air pollution exposure may affect the level of CC16,but the specific mechanism is not completely clear.In this paper,the relationship between indoor and outdoor air pollution exposure and children's CC16 and the mechanism of the effect of air pollution on CC16 are reviewed in detail.

导出引用

史航,朱运,吕雪峰,何钦成,马亚楠. 儿童空气污染暴露与CC16相关研究进展[J]. 中国儿童保健杂志. 2017, 25(2): 151-153 https://doi.org/10.11852/zgetbjzz2017-25-02-12

SHI Hang,ZHU Yun,LV Xue-feng,HE Qin-cheng,MA Ya-nan. Advances in research on children's exposure to air pollution and CC16[J]. Chinese Journal of Child Health Care. 2017, 25(2): 151-153 https://doi.org/10.11852/zgetbjzz2017-25-02-12

中图分类号： R179

参考文献

[1] Mcauley DF,Matthay MA.Clara cell protein CC16.A new lung epithelial biomarker for acute lung injury[J].Chest,2009,135(6):1408-1410.
[2] Kanchongkittiphon W,Mendell MJ,Gaffin JM,et al.Indoor environmental exposures and exacerbation of asthma:an update to the 2000 review by the institute of medicine[J].Environmental Health Perspectives,2015,123(1):6-20.
[3] 陈勇,孙海龙,贾红.北京市室外空气污染对慢性阻塞性肺疾病流行的影响及防控建议[J].环境与健康杂志,2014,31(7):632-635.
[4] Dunn AJ,Satcher D,Zeise L.Health effects of exposure to environmental tobacco smoke:the report of the california environmental protection agency[M].DIANE Publishing,2000:4-25.
[5] Laucho-Contreras ME,Polverino F,Tesfaigzi Y,et al.Club cell protein 16 (CC16) augmentation:a potential disease-modifying approach for chronic obstructive pulmonary disease (COPD)[J].Expert Opinion on Therapeutic Targets,2016,20(7):869-883.
[6] Reynolds S D,Mango G W,Gelein R,et al.Normal function and lack of fibronectin accumulation in kidneys of Clara cell secretory protein/uteroglobin deficient mice[J].American Journal of Kidney Diseases:the Official Journal of The National Kidney Foundation,1999,33(3):541-551.
[7] 吴峰,丁伯应,杨小龙.CC16 与肺部疾病关系的研究进展[J].临床肺科杂志,2014,19(9):1689-1691.
[8] Nagase T,Uozumi N,Ishii S,et al.A pivotal role of cytosolic phospholipase A(2) in bleomycin-induced pulmonary fibrosis[J].Nature Medicine,2002,8(5):480-484.
[9] Guerra S,Vasquez MM,Spangenberg A,et al.Serum concentrations of club cell secretory protein (Clara) and cancer mortality in adults:a population-based,prospective cohort study[J].The Lancet Respiratory Medicine,2013,1(10):779-785.
[10] Zhang Z,Kim SJ,Chowdhury B,et al.Interaction of uteroglobin with lipocalin-1 receptor suppresses cancer cell motility and invasion[J].Gene,2006,369:66-71.
[11] Halatek T,Gromadzinska J,Wasowicz W,et al.Serum Clara-cell protein and beta2-microglobulin as early markers of occupational exposure to nitric oxides[J].Inhalation Toxicology,2005,17(2):87-97.
[12] Provost EB,Chaumont A,Kicinski M,et al.Serum levels of club cell secretory protein (Clara) and short-and long-term exposure to particulate air pollution in adolescents[J].Environment International,2014,68(1):66-70.
[13] Arjomandi M,Tager IB,Bastaki M,et al.Is there an association between lifetime cumulative exposure and acute pulmonary responses to ozone?[J].Journal of Occupational and Environmental Medicine / American College of Occupational and Environmental Medicine,2008,50(3):341-349.
[14] Gomes EC,Allgrove JE,Florida-James G,et al.Effect of vitamin supplementation on lung injury and running performance in a hot,humid,and ozone-polluted environment[J].Scandinavian Journal of Medicine & Science in Sports,2011,21(6):e452-460.
[15] Klepeis NE,Nelson WC,Ott WR,et al.The National Human Activity Pattern Survey (NHAPS):a resource for assessing exposure to environmental pollutants[J].Journal of Exposure Analysis and Environmental Epidemiology,2001,11(3):231-252.
[16] 王海龙,王春芳,田树华,等.被动吸烟对大鼠肺组织 Clara 细胞及 CC16 的影响[J].环境与健康杂志,2008,(10):774-776.
[17] Ma YN,Qian Z,Wang J,et al.Environmental tobacco smoke exposure,urine CC-16 levels,and asthma outcomes among Chinese children[J].Allergy,2015,70(3):295-301.
[18] Kanchongkittiphon W,Mendell MJ,Gaffin JM,et al.Indoor environmental exposures and exacerbation of asthma:an update to the 2000 review by the Institute of Medicine[J].Environmental Health Perspectives,2015,123(1):6-20.
[19] Jacobs JH,Fuertes E,Krop EJ,et al.Swimming pool attendance and respiratory symptoms and allergies among Dutch children[J].Occupational and Environmental Medicine,2012,69(11):823-830.
[20] Bernard A,Nickmilder M,Dumont X.Chlorinated pool attendance,airway epithelium defects and the risks of allergic diseases in adolescents:Interrelationships revealed by circulating biomarkers[J].Environmental Research,2015,140:119-126.
[21] Dickens JA,Lomas DA.CC16 as a biomarker in chronic obstructive pulmonary disease[J].COPD,2012,9(5):574-575.
[22] Buro-Auriemma LJ,Salit J,Hackett NR,et al.Cigarette smoking induces small airway epithelial epigenetic changes with corresponding modulation of gene expression[J].Human Molecular Genetics,2013,22(23):4726-4738.
[23] Park HY,Churg A,Wright JL,et al.Club cell protein 16 and disease progression in chronic obstructive pulmonary disease[J].American Journal of Respiratory and Critical Care Medicine,2013,188(12):1413-1419.
[24] Ramsay PL,Luo Z,Major A,et al.Multiple mechanisms for oxygen-induced regulation of the Clara cell secretory protein gene[J].FASEB Journal:Official Publication of the Federation of American Societies for Experimental Biology,2003,17(14):2142-2144.
[25] Laing IA,Hermans C,Bernard A,et al.Association between plasma CC16 levels,the A38G polymorphism,and asthma[J].American Journal of Respiratory and Critical Care Medicine,2000,161(1):124-127.