目的 探讨新生儿新生儿呼吸窘迫综合征(NRDS)并发支气管肺发育不良(BPD)影响因素,从而为临床防治提供参考。方法 选取NRDS患儿200例,根据是否合并支气管肺发育不良(BPD)将其分为BPD组和非BPD组。总结患儿临床资料,采用单因素分析和Logistic多因素分析的方法分析BPD危险因素。结果 200例新生儿肺透明膜病(HMD)患儿中,共有BPD患儿48例,患病率为24.00%。随着胎龄的增大,BPD患病率呈下降趋势。随着出生体重的增加,BPD患病率呈下降趋势。单因素分析显示BPD和非BPD患者住院时间、肺出血发生率、出生体重、胎龄、机械通气时间、Apgar评分均有显著差异(P<0.05);多因素分析结果显示胎龄、体重、肺出血是影响BPD的危险因素(P<0.05)。结论 胎龄和体重是BPD的重要危险因素,临床上应给予预防措施,同时治疗肺部原发病对防止BPD有重要意义。
Abstract
Objective To explore the infuencing factors of neonatal respiratory distress syndrome (NRDS) combined bronchopulmonary dysplasia (BPD),and to provide reference for prevention and treatment. Methods 200 cases of children with NRDS,were divided into BPD groups and non-BPD group depending on whether the merger bronchopulmonary dysplasia (BPD).Summarize clinical data of children,risk factors of BPD were analized using univariate analysis and Logistic multivariate analysis method. Results In 200 HMD children,a total of 48 children with BPD,the prevalence was 24.00%.With increasing gestational age,BPD prevalence declined.With the increase of birth weight,BPD prevalence declined.Univariate analysis showed that hospital stay,incidence of pulmonary hemorrhage,birth weight,gestational age,duration of mechanical ventilation,Apgar score was significantly different between BPD group and non-BDP group (P<0.05);multivariate analysis showed that gestational age,weight,pulmonary hemorrhage were risk factors of BPD (P<0.05). Conclusion The gestational age and weight are important risk factors for BPD,preventive measures should be given in clinical,and treatment of lung primary disease is important in preventing BPD.
关键词
新生儿呼吸窘迫综合征 /
支气管肺发育不良 /
新生儿 /
危险因素
Key words
neonatal respiratory distress syndrome /
bronchopulmonary dysplasia /
newborns /
risk factors
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