目的 研究支气管哮喘儿童血清可溶性Fas受体和Fas配体(sFas/sFasL)的水平变化及临床意义。方法 选取67例支气管哮喘儿童(哮喘组)及健康儿童40例(对照组),采用双抗体夹心(ABC-ELISA)法检测哮喘组及对照组血清sFas、sFasL水平,并进行比较。结果 哮喘组血清sFas、sFasL水平分别为(91.89±21.25)、(1 080.37±306.59) ng/L均明显高于对照组的(29.58±7.26 )、(496.70±47.60) ng/L,差异有统计学意义(P<0.01)。结论 sFas、sFasL可能参与了儿童支气管哮喘的发病过程。
Abstract
Objective To explore the clinic significance of sFas/sFasL in serum of children with asthma. Methods A total of 67 children with asthma (asthma group) and 40 healthy children (healthy control group) were selected,sFas,sFasL in their serums were detected by ABC-ELISA. Results Compared with healthy control group,the sFas and sFasL in serum of asthma group were elevated markedly(P<0.01). Conclusion The sFas,sFasL in children with asthma were higher than healthy children,sFas/ sFasL maybe take part in the pathological process of asthma.
关键词
儿童 /
哮喘 /
sFas /
sFasL /
凋亡
Key words
asthma /
children /
SFas /
FasL /
apoptosis
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参考文献
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