目的 研究儿童青少年血压水平与血脂各组分的相关关系,为心血管病的早期预防和干预提供依据。方法 采用多阶段分层整群抽样,最终确定2 009名7~17岁学生作为研究对象,按照不同性别分组,分析血压水平与血脂各组分的相关关系。结果 Pearson相关分析显示,研究对象的血压水平与TG、TG/HDL-C、TC/HDL-C、non-HDL-C/HDL-C呈正相关 (P<0.05)。TC除了与女童SBP不相关外(P>0.05),与男童的SBP和DBP以及女童的DBP呈正相关 (P<0.05),TC/HDL-C与男女童的血压水平都呈正相关(P<0.05)。HDL-C除了与女童的DBP不相关外(P>0.05),与男童的SBP和DBP以及女童的SBP呈负相关 (P<0.05)。逐步回归分析显示,男童的SBP水平与TG、non-HDL-C、TG/HDL-C、non-HDL-C/HDL-C呈显著相关 (P<0.05),而DBP水平只与HDL-C呈显著相关 (P<0.05)。女童的DBP水平与TG、TG/HDL-C、LDL-C/HDL-C、non-HDL-C呈显著相关 (P<0.05),而SBP水平只与HDL-C呈显著相关 (P<0.05)。结论 儿童青少年的血压水平与血脂各组分呈现一定的相关关系,并且基于性别不同,相关程度表现出不同差异。
Abstract
Objective To examine the correlation between blood pressure level and lipid components among children and adolescent. Methods A total of 2 009 children and adolescent aged 7~17 were included in the present study.Subjects were grouped by gender,correlation between blood pressure level and lipid components. Results Pearson correlation analysis showed:Blood pressure level was positively correlated with TC,TG / HDL-C,TC / HDL-C,non-HDL-C / HDL-C(P<0.05).Besides SBP of female,TC was positively correlated with SBP and DBP of male and DBP of female (P<0.05).TC / HDL-C was positively correlated with SBP and DBP of male and female (P<0.05).Besides DBP of female,HDL-C was negatively correlated with SBP and DBP of male and SBP of female (P<0.05).Stepwise regression analysis showed:SBP level of male was significantly correlated with TG,non-HDL-C,TG / HDL-C,non-HDL-C / HDL-C (P<0.05),while the DBP level was only significantly correlated with HDL-C (P<0.05).DBP level of female was significantly correlated with TG,TG / HDL-C,LDL-C / HDL-C,non-HDL-C (P<0.05),while SBP level was only significantly correlated with HDL-C (P<0.05). Conclusions To a certain extent,blood pressure level is correlated with lipid components among children and adolescent.And based on different gender,the correlation degree shows significant difference.
关键词
收缩压 /
舒张压 /
脂代谢异常 /
儿童 /
青少年
Key words
systolic blood pressure /
diastolic blood pressure /
lipid metabolism abnormality /
children /
adolescent
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参考文献
[1] Braamskamp MJAM,Wijburg FA,Wiegman A.Drug therapy of hypercholesterolaemia in children and adolescents[J].Drugs,2012,72 (6):759-772.
[2] Descamps OS,Tenoutasse S,Stepbenne X,et al.Management of familial hypercholesterolemia in children and young adults:consensus paper developed by a panel of lipidologists,cardiologists,paediatricians,nutritionists,gastroenterologists,general practitioners and a patient organization[J].Atherosclerosis,2011,218(2):272-280.
[3] Friend A,Craig L,Turner S.The prevalence of metabolic syndrome in children:a systematic review of the literature[J].Metab Syndr Relat Disord,2013,11(2):71-80.
[4] Zhang Y,Zhou JY,Zhao JS,et al.Urban-rural and regional disparities in the prevalence of elevated blood pressure among children and adolescents in Shandong,China[J].Int J Cardiol,2014,3(176):1053-1055.
[5] 吴剑云,杨东,孙玉贞,等.东莞市横沥镇3-17岁儿童少年肥胖与高血压流行情况及危险因素分析[J].中国儿童保健杂志,2014,22(11):1191-1195.
[6] Redwine KM,Acosta AA,Poffenbarger T,et al.Development of hypertension in adolescents with pre-hypertension[J].J Pediatr,2012,160(1):98-103.
[7] 刘小晖,魏晶,李泽民,等.青岛市中小学生肥胖与血压关系分析[J].中国儿童保健杂志,2013,21(11):1209-1211.
[8] Bonita F.Hypertension in children and adolescents:epidemiology and natural history[J].Pediatr Nephrol,2010,25(7):1219-1224.
[9] Alsifri SN,Almahmeed W,Azar S,et al.Results of the dyslipidemia international study (DYSIS)-Middle East:clinical perspective on the prevalence and characteristics of lipid abnormalities in the setting of chronic statin treatment[J].PLoS One,2014,9:e84350.
[10] Prasanta KB,Utpala D,Dipankar B,et al.Distribution of blood pressure & correlates of hypertension in school children aged 5-14 years from Northeast India[J].Indian J Med Res,2015,142(3):293-300.
[11] 齐可民.儿童青少年血脂异常的特点与治疗[J].中华实用儿科临床杂志,2013,28(19):1510-1513.
[12] 刘益民,胡虞志,周德.儿童血压水平与血脂关系的研讨[J].中国学校卫生,1990,11(5):29-31.
[13] 董彬,马军,黄志达,等.青春期学生血压变化规律分析[J].中国学校卫生,2012,33(2):137-139.
[14] Borghi C,Cicero AFG,Saragoni S,et al.Rate of control of LDL cholesterol and incident hypertension requiring antihypertensive treatment in hypercholesterolemic subjects in daily clinical practice[J].Ann Med,2014,46:97-102.
[15] Deventer HE,Miller WG,Myers GL.Non-HDL cholesterol shows improved accuracy for cardiovascular risk score classification compared to direct or calculated LDL cholesterol in a dyslipidemic population[J].Clin Chem,2011,57(3):490-501.
[16] van Deventer HE,Miller WG,Myers GL,et al.Non-HDL cholesterol shows improved accuracy for cardiovascular risk score classification compared to direct or calculated LDL cholesterol in a dyslipidemic population[J].Clin Chem,2011,57:490-501.
[17] Srinivasan SR,Frontini MG,Xu J,et al.Utility of childhood non-high-density lipoprotein cholesterol levels in predicting adult dyslipidemic and other cardiovascular risks:the Bogalusa Heart Study[J].Pediatrics,2006,118:201-206.
[18] 陈联辉,施锡锋,梁黎.非高密度脂蛋白胆固醇的临床意义及其在儿科中的应用[J].中华儿科杂志,2013,51(6):436-438.
[19] Ruben OH,Howard DS,Jing M.Dyslipidemia and the Risk of Incident Hypertension in Men[J].Hypertension,2006,47:45-50.
[20] McGill HC,McMahan CA,Gidding SS.Preventing heart disease in the 21st century implications of the pathobiological determinants of atherosclerosis in youth (PDAY) study[J].Circulation,2008,117:1216-1227.
基金
卫生行业科研专项基金资助项目(201202010)