目的 研究孤立性侧脑室增宽胎儿的智力运动发育水平,用于孕期优生优育的指导和发育异常患儿的早期发现和治疗。方法 对孕期诊断为孤立性侧脑室增宽的患儿进行随访,采用儿童发育量表评估患儿的智力运动发育水平。结果 72例孤立性侧脑室增宽儿童中37例(51.4%)智力发育指数MDI≥80,27例(37.5%)神经运动发育指数PDI≥80 。57例妊娠末期侧脑室扩张未消失的儿童16例(28.1%)智力发育指数MDI≥80,18例(31.6%)神经运动发育指数PDI≥80。15例妊娠末期侧脑室扩张逐渐消失的儿童11例(73.3%)智力发育指数MDI≥80,10例(66.7%)神经运动发育指数PDI≥80。68例轻度侧脑室增宽儿童智力发育指数78.86±19.663,神经运动发育指数72.40±18.579。10例单侧侧脑室增宽儿童智力发育指数86.10±11.836,神经运动发育指数81.40±14.804。4例重度侧脑室增宽儿童智力发育指数<50,神经运动发育指数<50。轻度侧脑室增宽、单侧侧脑室增宽与重度侧脑室增宽的儿童智力发育指数和神经运动发育指数差异有统计学意义(P<0.05),轻度侧脑室增宽与单侧侧脑室增宽的儿童智力发育指数和神经运动发育指数差异无统计学意义(P>0.05)。三组儿童的智力发育指数和神经运动发育指数均低于健康儿童的平均水平。结论 孤立性轻度侧脑室增宽智力发育指数和神经运动发育指数均低于健康儿童的平均水平,且重度侧脑室增宽儿童出现了明显的发育障碍。今后应加强此类胎婴儿的监测,争取早期发现和治疗。
关键词
侧脑室增宽 /
胎儿 /
预后
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
[1] Melchiorre K,Liberati M,Celentano C,et al.Neurological outcome following isolated 10~20 mm fetal ventriculomegaly[J].Arch Dis Child Fetal Neonatal Ed,2009,94:F311-F312.
[2] Gaglioti P,Danelon D,Bontempo S,et al.Fetal cerebral ventriculomegaly:outcome in 176 cases[J].Ultrasound Obstet Gynecol,2005,25(4):372-377.
[3] 边旭明.实用产前诊断学[M].北京:人民军医出版社,2008:520-521.
[4] Griffiths PD,Reeves MJ,Morris JE,et al.A prospective study of fetuses with isolated ventriculomegaly investigated by antenatal sonography and in utero MR imaging[J].AJNR Am J Neuroradiol,2010,31(1):106-111.
[5] Pagani G,Thilaganathan B,Prefumo F.Neurodevelopmental outcome in isolated mild fetal ventriculomegaly:systematic review and meta-analysis[J].Ultrasound Obstet Gynecol,2014,44(3):254-260.
[6] Leitner Y,Stolar O,Rotstein M,Toledano H ,et al.The neurocognitive outcome of mild isolated fetal ventriculomegaly verified by prenatal magnetic resonance imaging[J].Am J Obstet Gynecol.2009,201(2):215.e1-6.
[7] Kennelly MM,Cooley SM,Mc Parland PJ,et al.Natural history of apparently isolated severe fetal ventriculomegaly:perinatal survival and neurodevelopmental outcome[J].Prenat Diagn,2009,29:1135-1140.
[8] Ouahba J,Luton D,Vuillard E,et al.Prenatal isolated mild ventriculomegaly:outcome in 167 cases[J].BJOG,2006,113:1072-1079.
[9] Kandula T,Fahey M,Chalmers R,et al.Isolated ventriculomegaly on prenatal ultrasound:what does fetal MRI add Edwards A[J].J Med Imaging Radiat Oncol,2015,59(2):154-162.
PDF(580 KB)
