目的 通过静息和任务状态脑电功率的比较研究,探讨新生儿脑功能的发展特征。方法 足月新生儿53名,按日龄分三组(第一组1~10 d,第二组11~20 d,第三组21~28 d)。oddball范式听觉刺激下记录任务脑电,进行静息(常规)与任务δ频段脑电功率的比较分析。结果 1) Cz导联第二、三组任务均较静息脑电功率明显增加[二组静息:(281.41±121.73)μV2,任务:(334.42±135.95)μV2;三组静息:(166.39±84.43)μV2,任务:(216.64±89.85)μV2],差异有统计学意义(P<0.05);2) Cz导联三组任务脑电功率发展比较[一组:(203.68±165.96)μV2;二组:(334.42±135.95)μV2;三组:(216.64±89.85)μV2],差异有统计学意义(P<0.05)。结论 新生儿在认知信息加工时脑神经元激活数量上升,使任务脑电功率增强;新生儿δ频段脑电功率随日龄增加而变化,在11~20 d呈最高的特征。接受适当的认知信息,可以促进新生儿脑功能发展。
Abstract
Objective To explore the characteristic of neonatal brain function and development by the comparative research on resting and tasking electroencephalogram(EEG) power. Methods A total of 53 full-term babies were divided into three groups (the first group of 1 to 10 days,the second group of 11~20 days,the third group 21~28 days),tasking EEG was elicited by oddball paradigm auditory stimuli,comparative analysis was carried out between resting (normal) and tasking EEG power in delta frequency band. Results 1)Compared with resting,the increase of tasking EEG power was remarkable in group 2 and 3 at Cz lead [group 2:(281.41±121.73)μV2 vs (334.42±135.95)μV2;group 3:(166.39±84.43)μV2 vs (216.64±89.85)μV2 (P<0.05)];2)Development analysis on the tasking EEG power in three groups at Cz lead [group 1:(203.68±165.96)μV2;group 2:(334.42±135.95)μV2;group3:(216.64±89.85)μV2] showed a significant difference (P<0.05). Conclusion The quantity of neonatal brain activated neurons rised when cognitive information processed,which make the tasking EEG power enhanced;The δ EEG power in newborn changes with age,and reaches the maximum in 11~20 days.Accepting appropriate cognitive information can promote the development of neonatal brain function.
关键词
新生儿 /
脑电功率 /
脑功能 /
发展
Key words
neonates /
electroencephalogram(EEG) power /
brain function /
development
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参考文献
[1] Shi T,Xia L,Jia S,et al.EEG characteristics and visual cognitive function of children with attention deficit hyperactivity disorder (ADHD)[J].Brain & Development,2012,34(10):806-811.
[2] Ogrim G,Kropotov J,Hestad K.The quantitative EEG theta/beta ratio in attention deficit/hyperactivity disorder and normal controls:Sensitivity,specificity,and behavioral correlates[J].Psychiatry Research,2012,198(3):482-488.
[3] Raye-Ann,deRegnier.Neurophysiologic evaluation of brain function in extremely premature newborn infants[J].Seminars in Perinatology,2008,32(1):2-10.
[4] Chipaux M,Colonnese MT,Mauguen A,et al.Auditory stimuli mimicking ambient soundsdrive temporal "delta-brushes" in premature infants[J].PloS One,2013,8(11):e79028.
[5] Güntekin B,Ba ar E.Review of evoked and event-related delta responses in the human brain[J].International Journal of Psychophysiology,2015,2(1):1-10.
[6] Guzzetta F,Conti G,Mercuri E.Auditory processing in infancy:do early abnormalities predict disorders of language and cognitive development?[J].Developmental Medicine & Child Neurology,2011,53(12):1085-1090.
[7] 高延,洪琦.婴儿事件相关电位的研究进展[J].癫癎与神经电生理学杂志,2012,21(1):45-48.
[8] Liu B,Meng X,Wu G,et al.Correlation between three-dimensional visual depth and N2 component:Evidence from event-related potential study[J].Neuroscience,2013,237:161-169.
[9] Cuevas K,Bell M A.EEG and ECG from 5 to 10months of age:Developmental changes in baseline activation and cognitive processing during a working memory task[J].International Journal of Psychophysiology,2011,80(2):119-128.
[10] 郭明霞,李岳峙,刘瑾,等.注意状态对听觉事件相关电位及脑电功率的影响[J].中华物理医学与康复杂志,2004,26(7):408-410.
[11] Bell MA,Wolfe CD.Changes in brain functioning from infancy to early childhood:evidence from EEG power and coherence during working memory tasks[J].Developmental Neuropsychology,2007,31(1):21-38.
[12] Otero GA,Harmony T,Pliego-Rivero FB,et al.QEEG norms for the first year of life.[J].Early Human Development,2011,87(10):691-703.
[13] Sankupellay M,Wilson S.Characteristics of sleep EEG power spectra in healthy infants in the first two years of life[J].Clinical Neurophysiology,2011,122(2):236-243.
[14] Lippé S,Kovacevic N,McIntosh AR.Differential maturation of brain signal complexity in the human auditory and visual system[J].Frontiers in Human Neuroscience,2009,3(4):481-9.
[15] Niemarkt HJ,Jennekens W,Pasman JW,et al.Maturational changes in automated EEG spectral power analysis in preterm infants[J].Pediatric Research,2011,70(5):529-534.
[16] Cirelli C,Tononi G.Cortical development,electroencephalogram rhythms,and the sleep/wake cycle[J].Biological Psychiatry,2014,77(12):1071-1078.
基金
江苏省省级条件建设与民生科技专项资金项目(BL2014037);常州市“科技支撑-社会发展”项目(CE20135045)
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