目的 探讨妊娠期高血压及子痫前期对妊娠及新生儿结局的影响,为育龄妇女孕前、孕期及产后保健提供依据,以减少不良妊娠结局的发生,并为新生儿的健康管理提供预警信息。方法 以前瞻性队列研究为基础的巢式病例对照研究,暴露组84例,其中妊娠期高血压39例、子痫前期45例,按1∶1比例分层随机选择对照组(健康孕妇),使其在分娩年龄、分娩孕周、孕前体质指数、孕次、产次五方面成组匹配,比较两组间妊娠结局及新生儿情况的差别,进一步按妊娠期高血压和子痫前期对暴露组分层与对照组比较。结果 暴露组在分娩方式、早产、宫内缺氧、低出生体重儿、转新生儿科或转院、新生儿出生体重、身长、生后1 min和5 min Apgar评分方面与对照组相比,差异均存在统计学意义(P<0.05),且子痫前期导致的不良妊娠及新生儿结局更严重。结论 妊娠期高血压及子痫前期对孕妇及新生儿造成了不良影响,应当加强育龄妇女的保健,积极预防和治疗妊娠期高血压疾病,实现优生。
Abstract
Objective To investigate the influence of gestational hypertension and preeclampsia on pregnancy outcome,to decrease the adverse maternal outcome and promote the neonatal health. Methods A nested case-control study based on a prospective cohort.The pregnancy outcome of the case group which included 39 women with gestational hypertension and 45 with preeclampsia was compared with the control group (n=84),and the two groups were matched at the pregnancy age,gestational week,BMI,gravidity,parity. Results The differences in cesarean section,preterm,intrauterine hypoxia,low birth weight,in-patient,birth weight,height,1 min Apgar score,5 min Apgar score were significant compared with the control group (P<0.05).The preeclampsia induced a more serious outcome of women and infant. Conclusions Gestational hypertension and preeclampsia induced maternal and neonatal adverse outcomes,more attention should be paid to maternal health care,prevents and treats the pregnancy induced hypertension disease positively,realizes the eugenics.
关键词
妊娠期高血压 /
子痫前期 /
妊娠结局 /
新生儿
Key words
gestational hypertension /
preeclampsia /
pregnancy outcome /
neonate
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基金
国家自然科学基金(81402687);上海市科学技术委员会引导类课题(14411970900);上海市浦东新区卫生和技术委员会联合攻关项目(PW2013D-9)
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