目的 探讨孕妇妊娠期糖尿病(GDM)对新生儿生后一周内肾功能的影响。方法 选择2014年7月-2015年6月期间佛山市妇幼保健院新生儿科收治的60例GDM母亲所生新生儿作为观察组,选择同期60例健康母亲所生新生儿作为对照组,检测生后1、3、7 d三个时间点的血清尿素氮(BUN)、肌酐(CREA)、胱抑素C(Cys-C)、β2微球蛋白(β2-MG),并进行比较。结果 生后第1天观察组新生儿β2-MG、Cys-C等指标水平显著高于对照组,差异有统计学意义(P＜0.05),两组血清BUN、CREA差异无统计学意义(P＞0.05);生后第3天、第7天观察组β2-MG水平显著高于对照组(P＜0.05),血清Cys-C差异无统计学意义(P＞0.05);观察组足月儿β2-MG指标水平显著高于对照组,差异有统计学意义(P＜0.05),血清Cys-C生后第1天有差异,生后第3天、第7天差异无统计学意义(P＞0.05);观察组早产儿β2-MG生后第3天显著高于对照组,差异有统计学意义(P＜0.05),生后第1天、第7天差异无统计学意义;血清Cys-C生后第1天有差异,生后第3天、第7天差异无统计学意义(P＞0.05)。结论 GDM 母亲所生新生儿可能存在早期肾功能损害,但随日龄增长,肾功能逐渐恢复,Cys-C较β2-MG先恢复正常。
Abstract
Objective To investigate the effect of gestation diabetes mellitus(GDM) on the renal function in newborn within 7 days. Methods All the cases involved in this study were neonates borned in Foshan Maternal and Child Health Care Hospital from July 2014 to June 2015,60 cases whose mother had suffered from GDM were selected into the observation group,and other 60 cases who were borned in the same period were selected into the control group,and whose mother had not suffered from GDM.The levels of BUN,CREA,Cystatin C (Cys-C),β2-microglobulin(β2-MG) in serum were detected and compared in day 1,3 and 7. Results Compared with the control group,the levels of Cys-C and β2-MG in observation group were higher in day 1 (P<0.05),neither BUN nor CREA levels had significant change (P>0.05).The levels of β2-MG were higher in day 3 and 7 (P<0.05),but the levels of Cys-C had no significant changes (P>0.05).For the term infants,the level of β2-MG was higher in observation group (P<0.05),the level of Cys-C was higher only in day 1 (P<0.05);For the preterm infants,the level of β2-MG was higher in observation group in day 3 (P<0.05),the level of Cys-C was higher only in day 1 (P<0.05). Conclusions There is renal damage in neonates borned by GDM mothers,but the neonatal renal function improved within 1 weeks,and the level of Cys-C returned to normal earlier than β2-MG.
关键词
妊娠期糖尿病 /
新生儿 /
肾功能
Key words
gestational diabetes mellitus /
neonate /
renal function
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参考文献
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基金
佛山市医学类科技攻关项目(2014AB00365)
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