目的 描述北京市顺义区2006-2012年神经管缺陷(neural tube defects,NTDs)的流行病学特征,为NTDs的预防提供参考依据。方法 利用顺义区的出生缺陷监测资料,描述NTDs及其亚型的患病率和变化趋势。结果 2006-2012年顺义区NTDs患病率为12.6/104(监测时限为孕13周至产后7 d),无脑畸形、脊柱裂、脑膨出的患病率依次为6.7/104、4.9/104、1.0/104。2006-2012年NTDs总患病率未见下降趋势,各亚型中脊柱裂患病率下降趋势有统计学意义(P<0.05)。户籍人口NTDs患病率(6.8/104)低于流动人口(20.0/104)(P<0.01)。结论 7年间顺义区NTDs患病率无趋势性变化,但脊柱裂患病率有下降趋势。顺义区还需进一步加强流动人口NTDs的预防。
Abstract
Objective To explore the epidemiological characteristics of neural tube defects (NTDs) in Shunyi district from 2006 to 2012. Method Data from Shunyi district's birth defects monitoring network were used to describe the prevalence and the trends of NTDs. Results The prevalence of NTDs was 12.6/104.The prevalence rates of anencephaly,spina bifida,and encephalocele were 6.7/104,4.9/104 and 1.0/104,respectively.The change tendency of overall prevalence rates of NTDs were not statistical significantly,while the prevalence rates of spina bifida was decreased from 2006 to 2012 (P<0.05).The prevalence of NTDs among permanent residence in Beijing was 6.8/104,and the prevalence among the floating population was 20.0/104 births (P<0.01). Conclusions The prevalence of NTDs in Shunyi is 12.6/104 without time trend for variations while the prevalence rates of spina bifida is decreased from 2006 to 2012.The prevalence of NTDs among floating population is higher than permanent residence in Beijing.Strengthen the NTDs prevention among flowing population is suggested.
关键词
出生缺陷 /
神经管缺陷 /
患病率 /
监测 /
叶酸
Key words
birth defects /
neural tube defects /
prevalence /
surveillance /
folic acid
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参考文献
[1] Wallingford JB,Niswander LA,Shaw GM,et al.The continuing challenge of understanding and preventing neural tube defects[J].Science,2013,339(6123):1222002.
[2] 尚肖肖,王志萍,赵仲堂.叶酸预防神经管缺陷卫生经济学评价研究进展[J].中国公共卫生,2010,26(8):1063-1064.
[3] 中华人民共和国卫生部,中国出生缺陷防治报告(2012)[R].2015.http://www.gov.cn/gzdt/att/att/site1/20120912/1c6f6506c7f811bacf9301.pdf.
[4] The Center of the International Cleaninghouse for Birth Defects Surveillance and Research.Annual report 2011 with data for 2009,2011[EB/OL].http://www.icbdsr.org/filebank/documents/ar2005/Report2011.pdf.
[5] 北京市卫生局,北京市卫生局关于印发《北京市出生缺陷监测登记报告管理制度》的通知,2008[EB/OL].http://www.bjhb.gov.cn/zwfwq/wyljwsfw/fyyjsws/gfxwj/201011/t20101112_19138.htm.
[6] 闫明,刘凯波,张雯.北京地区增补叶酸预防神经管缺陷项目数据分析[J].中国优生与遗传杂志,2014,22(2):96-98.
[7] 郁静茹,金蕾,肖利华,等.2006～2012年北京市通州区出生缺陷患病率的动态变化[J].中国当代儿科杂志,2014,16(11):1133-1137.
[8] 王海英.北京市顺义区2006～2008年围产儿出生缺陷调查[J].中国计划生育学杂志,2009,17(7):416-418.
[9] 任爱国.叶酸预防神经管缺陷[J].北京大学学报:医学版,2014,(3):343-346.
[10] 北京市卫生局,北京市财政局,北京市人口和计划生育委员会.关于印发《北京市增补叶酸预防神经管缺陷工作实施方案(试行)》的通知,2011[OB/OL].http://zfxxgk.beijing.gov.cn/fgdyna.prinfodetail.prDynaDetailInfo.do?GM_T_CATALOG_INFO/CATA_INFO_ID=259674.
[11] 周亚玲,王晓红.北京市怀柔区1998年至2013年神经管缺陷监测数据分析[J].中国优生与遗传杂志,2015,21 (5):97-98.
[12] 毛康娜,李丹丹,周钰.北京市海淀区孕产妇增补叶酸现状分析[J].中国优生与遗传杂志,2013,19(2):80-81.
[13] 秦宏宇,刘昂.北京市流动人口的现状、特点、趋势与政策应对[J].北京政法职业学院学报,2014,28(2):89-96.
[14] 曹家宁.北京市流动人口就业状况影响因素分析-基于2011年北京市流动人口动态监测数据的实证研究[D].北京:中央民族大学,2014.
[15] 向明明.在京流动人口城市生活适应状况调查-以北京大兴区某流动人口社区为例[J].湖南广播电视大学学报,2012,12(1):73-78.
[16] 廖艳,周俭,刘会,等.北京市流动人口中孕妇营养知识、态度和行为的研究[J].现代预防医学,2010,37(1):66-68,72.
[17] Berry RJ,Li Z,Erickson JD.et al.Prevention of neural-tube defects with folic acid in China.China-U.S.Collaborative project for neural tube defect prevention[J].New England Journal of Medicine,1999,341(20):1485-1491.
[18] 陈筱云,颜育云.免费叶酸增补项目实施后人群知行情况分析[J].上海预防医学,2013,25 (6):311-313.
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