胚胎停育影响因素的Meta分析

郭立燕; 翟敏; 王莎莎; 张妍

doi:10.11852/zgetbjzz2016-24-02-16

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中国儿童保健杂志 ›› 2016, Vol. 24 ›› Issue (2) : 166-179. DOI: 10.11852/zgetbjzz2016-24-02-16

临床研究与分析

胚胎停育影响因素的Meta分析

郭立燕,翟敏,王莎莎,张妍

作者信息 +

Meta-analysis of risk factors related to the induction of embryo damage

GUO Li-yan,ZHAI Min,WANG Sha-sha,ZHANG Yan

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文章历史 +

摘要

目的利用Meta分析方法探讨影响妇女胚胎停育的危险因素,为防治措施的制定提供理论依据。方法通过文献检索收集有关胚胎停育病例对照研究的文献,采用随机效应模型和固定效应模型通过Review Manager 5.2软件进行综合定量分析评价。结果纳入文献37篇,累计病例组7 223例,对照组6 689例;有统计学意义的因素及其合并OR(95%CI):沙眼衣原体8.46(5.84~12.25)、解脲支原体6.13(4.45~8.43)、沙眼衣原体与解脲支原体混合感染5.90(3.77~9.25)、电磁辐射4.83(3.63~6.44)、被动吸烟4.27(3.76~4.85)、家庭装修2.11(1.76~2.54)、妊娠焦虑1.42 (1.25~1.59);婚检0.60(0.51~0.71)、体育锻炼0.45(0.35~0.57)。结论沙眼衣原体、解脲支原体、沙眼衣原体与解脲支原体混合感染、电磁辐射、被动吸烟、家庭装修是胚胎停育的危险因素,婚检、体育锻炼则是胚胎停育的保护性因素。

Abstract

Objective To investigate the risk factors related to the induction of embryo damage with meta-analysis and to provide theoretic evidence for the exploration and prevention. Methods References related to embryo damage were retrieved and collected with case-control study.Mantel-Haensel fixed effect model and Dersimonian-Laird random effect model were used to perform meta-analysis by Review Manager 5.2. Results Thirty-seven articles which included 7 223 cases in embryo damage group and 6 689 cases in control group were synthetically and quantitatively analyzed by Meta-analysis.The factors with odds ratios and 95% confidence intervals in descending order were Chlamydia trachomatis 8.46(5.84~12.25),Mycoplasma urealytium 6.13(4.45~8.43),Chlamydia trachomatis and mycoplasma urealytium 5.90(3.7 7~9.25),radiation 4.83(3.63~6.44),smoking passively 4.27(3.76~4.85),home decoration 2.11(1.76~2.54),pregnancy anxiety 1.42 (1.25~1.59);pre-marital check-up 0.60(0.51~0.71),physical exercise 0.45(0.35~0.57).All these factors were statistically significant. Conclusion Chlamydia trachomatis,Mycoplasma urealytium,radiation and smoking passively were considered to be risk factors of embryo damage,while pre-marital check-up and physical exercise might be associated with protective factors.

导出引用

郭立燕,翟敏,王莎莎,张妍. 胚胎停育影响因素的Meta分析[J]. 中国儿童保健杂志. 2016, 24(2): 166-179 https://doi.org/10.11852/zgetbjzz2016-24-02-16

GUO Li-yan,ZHAI Min,WANG Sha-sha,ZHANG Yan. Meta-analysis of risk factors related to the induction of embryo damage[J]. Chinese Journal of Child Health Care. 2016, 24(2): 166-179 https://doi.org/10.11852/zgetbjzz2016-24-02-16

中图分类号： R179

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