锂对缺氧缺血性脑损伤神经修复机制研究进展

陈长春 综述, 尹晓娟 审校

中国儿童保健杂志 ›› 2016, Vol. 24 ›› Issue (2) : 156-159.

PDF(560 KB)
PDF(560 KB)
中国儿童保健杂志 ›› 2016, Vol. 24 ›› Issue (2) : 156-159. DOI: 10.11852/zgetbjzz2016-24-02-13
综述与讲座

锂对缺氧缺血性脑损伤神经修复机制研究进展

  • 陈长春 综述, 尹晓娟 审校
作者信息 +
文章历史 +

摘要

围生期新生儿缺氧缺血性脑损伤(hypoxic-ischemic brain damage,HIBD)是目前新生儿死亡和婴幼儿致残的主要原因,全球有23%新生儿死于该病,部分幸存者可发生脑性瘫痪、智力低下、癫痫等永久性脑损害。临床早期采取亚低温和重复注射小剂量的促红细胞生成素是目前治疗该病的较有效措施,但其能否改善远期预后仍然不为人知。这就迫切需要发展新的脑补救策略。动物实验表明,锂对HIBD具有潜在的神经保护效应,其作用机制已经受到广泛关注,下面就锂的神经保护作用机制作一综述。

关键词

/ 神经修复 / 缺氧缺血性脑损伤 / 机制

引用本文

导出引用
陈长春 综述, 尹晓娟 审校. 锂对缺氧缺血性脑损伤神经修复机制研究进展[J]. 中国儿童保健杂志. 2016, 24(2): 156-159 https://doi.org/10.11852/zgetbjzz2016-24-02-13
中图分类号: R179   

参考文献

[1] 张赟.TLR2在骨髓间充质干细胞修复缺氧缺血性脑损伤中的作用及机制[D].重庆:重庆医科大学,2013.
[2] Smith AL,Alexander M,Rosenkrantz TS,et al.Sex differences in behavioral outcome following neonatal hypoia ischemia:Insights from a clinical meta-analysis and a rodent model of induced hypoxic ischemic brain injury[J].Exp Neurol,2014,254:54-67.
[3] 王钰,尹晓娟.锂对新生儿缺血缺氧性脑损伤神经保护作用的研究进展[J].中国儿童保健杂志,2011,19(11),1002-1004.
[4] Camins A,Crespo-Biel N,Junyent F,et al.Calpains as a target for therapy of neurodegenerative diseases:putative role of Lithium[J].Current Drug Metabolism,2009,10(5),433-447.
[5] Li Q,Li H,Roughton K,et al.Lithium reduces apoptosis and autophagy after neonatal hypoxia-ischemia[J].Cell Death Dis,2010,1(7):56-59.
[6] Can A,Schulze TG,Gould TD.Molecular actions and clinical pharmacogenetics of lithium therapy[J].Pharmacol Biochem Behav,2014,123:3-16.
[7] Shin WJ,Gwak M,Baek CH,et al.Neuroprotective effects of lithium treatment following hypoxic-ischemic brain injury in neonatal rats[J].Childs NervSyst,2012,28(2):191-198.
[8] Rybakowski JK.Response to Lithium in Bipolar Disorder:clinical and genetic findings[J].ACS Chem Neurosci,2014,5(6):413-421.
[9] Keshavarz M,Emamghoreishi M,Nekooeian AA,et al.Increased bcl-2 protein levels in rat primary astrocyte Culture Following Chronic Lithium Treatment[J].Iran J Med Sci,2013,38(3):255-262.
[10] Cabrera O,Dougherty J,Singh S,et al.Lithium protects against glucocorticoid induced neural progenitor cell apoptosis in the developing cerebellum[J].Brain Res,2014,1545:54-63.
[11] 邵肖梅,叶鸿瑁,丘小灿.实用新生儿学[M].4版.北京:人民卫生出版社,2011:700-701.
[12] Tang XJ,Xing F.Calcium-permeable AMPA receptors in neonatal hypoxic-ischemic encephalopathy[J].Biomed Rep,2013,1(6):828-832.
[13] Pasquali L,Busceti CL,Fulceri F,et al.Intracellular pathways underlying the effects of lithium[J].Behav Pharmacol,2010,21(5-6):473-492.
[14] Tian N,Kanno T,Jin Y,et al.Lithium potentiates GSK-3βactivity by inhibiting phosphoinositide 3-kinase-mediated Akt phosphorylation[J].Biochem Biophys Res Commun,2014,450(1):746-749.
[15] Motoi Y,Shimada K,Ishiguro K,et al.Lithium and autophagy[J].ACS Chem Neurosci,2014,5(6):434-442.
[16] Leeds PR,Yu F,Wang Z,et al.A new avenue for Lithium:intervention in traumatic brain Injury[J].ACS Chem Neurosci,2014,5(6):422-433.
[17] Dzietko M,Derugin N,Wendland MF,et al.Delayed VEGF treatment enhances angiogenesis and recovery after neonatal focal rodent stroke[J].Transl Stroke Res,2013,4(2):189-200.
[18] Chan CB,Ye K.Phosphoinositide 3-kinase enhancer (PIKE) in the brain:is it simply a phosphoinositide 3-kinase/Akt enhancer?[J].Rev Neurosci,2012,23(2):153-161.
[19] Chiu CT,Chuang DM.Molecular actions and therapeutic potential of lithium in preclinical and clinical studies of CNS disorders[J].Pharmacol Ther,2010,128(2):281-304.
[20] Fan M,Song C,Wang T,et al.Protective effects of lithium chloride treatment on repeated cerebral ischemia-reperfusion injury in mice[J].Neurol Sci,2015,36(2):315-321.
[21] Xie C,Zhou K,Wang X,et al.Therapeutic benefits of delayed lithium administration in the neonatal rat after cerebral hypoxia-ischemia[J].PLoS One,2014,9(9):e107192.
[22] Li H,Li Q,Du X,et al.Lithium-mediated long-term neuroprotection in neonatal rat hypoxia-ischemia is associated with antiinflammatory effects and enhanced proliferation and survival of neural stem/progenitor cells[J].J Cereb Blood Flow Metab,2011,1(10):2106-2115.
[23] Chicha L,Smith T,Guzman R.Stem cells for brain repair in neonatal hypoxia-ischemia[J].Childs Nerv Syst,2014,30(1):37-46.
[24] 王钰,尹晓娟.锂对缺氧状态下新生鼠神经干细胞损伤的影响[J].中国儿童保健杂志,2013,21(10):1045-1048.

基金

中国博士后基金(20070410505)

PDF(560 KB)

Accesses

Citation

Detail

段落导航
相关文章

/