目的 了解苏州地区学龄前儿童幽门螺杆菌(Hp)的感染情况,为儿童保健工作提供技术保障和临床理论依据。方法 对204名学龄前儿童通过问卷调查其基本信息;体检了解受检儿童的身高、体重、血红蛋白指标、口腔龋齿情况;采用13C-尿素呼气试验(13C-UBT)和幽门螺杆菌唾液检测试剂(HPS)方法检测胃和口腔Hp感染。结果 204例儿童13C-UBT阳性37例(18.13%),男19例(18.45%),女18例(17.82%);HPS阳性158例(77.45%),男84例(81.55%),女74例 (73.27%);13C-UBT与HPS均阳性28例(13.72%),男14例(13.59%),女14例 (13.59%)。各组性别间比较差异无统计学意义(P＞0.05),口腔Hp感染显著高于胃内Hp感染(P＜0.01),13C-UBT与 HPS的符合率为31.86%。口腔Hp感染的家庭中父母有胃病史者,显著多于无胃病史者(P＜0.01)。口腔Hp感染与龋齿的关系无统计学意义(P＞0.05)。胃Hp感染和未感染组间的身高、体重、血红蛋白比较差异无统计学意义(P＞0.05)。结论 苏州地区学龄前儿童口腔感染显著高于胃內感染。父母有胃病史的儿童,口腔Hp感染率更高。应尽早、准确地发现Hp 感染,采取积极有效的干预措施,可减少因Hp感染引起的疾病发生。
Abstract
Objective To realize the situation of Helicobacter pylori (HP) infection in preschool children in Suzhou and provide the technical support and theoretical basis of clinical for children health service. Methods Basic informations of 204 preschool children through questionnaires were collected.The children were given a physical examination to acquire height,weight,hemoglobin index,oral caries situation,and detected of Hp infection in oral and stomach by using 13C-urea breath test(13C-UBT) and HP saliva test kit (HPS). Results In total 204 cases,children with 13C-UBT positive were 37 cases (18.13%,19 male,18 female);HPS positive were 158 (77.45%,84 male,74 female);and both 13C-UBT and HPS positive were 28 cases (13.72%,14 male,14 female).There was no significant difference (P>0.05) between each gender.The rate of oral HP infection was significantly higher than that of the stomach HP infection (P<0.01),the coincidence between 13C-UBT and HPS was 31.86%.Oral HP infected children's parents had more stomach problems than those without disorder of stomach (P<0.01).The relationship between Oral HP infection and dental caries was not statistically significant (P>0.05).There were no significant differences (P>0.05) in height,weight and hemoglobin between infected and uninfected children. Conclusion The rate of preschool children's oral infection is significantly higher than that of the stomach infection in Suzhou.Children whose parents had a history of stomach disorder have a higher incidence on the prevalence of their children's oral HP.Discovering HP infection early and accurately and taking positive and effective interventions can reduce the occurrence of diseases caused by HP infection.
关键词
幽门螺杆菌 /
学龄前儿童 /
儿童保健
Key words
helicobacter pylori /
preschool children /
children&apos /
s health
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参考文献
[1] Warren JR,Marshall B.Unidentified curved bacilli on gastric epithelium in a ctive chronic gastritis[J].Lancet,1983,1:1273-1275.
[2] Salaspuro MP.Acetaldehyde,microbes,and cancer of the digestive tract[J].Crit Rev Clin Lab Sci,2003,40(2):183-185.
[3] Santacroce L,Cagiano R,Del Prete R,et al.Helicobacter pylori infection and gastric MAL Tomas:an up-to-date and therapy highlight[J].Clin Ter,2008,159:457-462.
[4] Queiroz DM,Rocha AM,Crabtree JE.Unintended consequences of Helicobacter pylori infection in children in developing countries:iron deficiency,diarrhea,and growth retardation[J].Gut Microbes,2013,4(6):494-504.
[5] Spee LA,Madderom MB,Piipers M,et al.Association between helicobacter pylori and gastrointestinal symptoms in children[J].Pediatrics,2010,125(3):651-69.
[6] Wu KS,Hsiao CC,Yu HR,et al.Helicobacter pylori infection and childhood idiopathic thrombocytopenic purpura[J].Acta Paediatr Taiwan,2007,48(5):263-266.
[7] Franceschi F,Zuccala G,Roccarina D,et al.Clinical effects of Helicobacter pylori outside the stomach[J].Nat Rev Gastroenterol Hepatol,2014,11(4):234-242.
[8] Wang Q,Yu C,Sun Y.The association between asthma and Helicobacter pylori:a meta-analysis[J].Helicobacer,2013,18(1):41-53.
[9] Pasceri V,Patti G,Cammarota G,et al.Virulent strains of Helicobacter pylori and vascular diseases:a meta-analysis[J].Am Heart J,2006,151(6):1215-1222.
[10] Krajden S,Fuksa M,Anderson J,et al.Examination of human stomach biopsies,saliva,and dental plaque for Campylobacter pylori[J].J Clin Microbiol,1989,27(6):1397-1398.
[11] Tiwari SK,Khan AA,Ahmed KS,et al.Rapid diagnosis of Helicobacter pylori infection in dyspeptie patients using salivary secretion:a non-invasive approach[J].Singapore Med J,2005,46(5):224-228.
[12] Wang J,Chi DS,Laffan JJ,et al.Comparison of cytotoxin genotypes of Helicobacter pylori in stomach and saliva[J].Dig Dis Sci,2002,47(8):1850-1856.
[13] Dore-Davin C,Heitz M,Yang H,et al.Helicobacter pylori in the oral cavity reflects handling of contaminants but not gastric infection[J].Digestion,1999,60(3):196-202.
[14] Leat YA,Flores LL,Fuentes-Panana EM,et al.13C-uren breath test for the diagnosis of Helicobacter pylori infection in children:a systematic review and meta-analysis[J].Helicobacter,2011,16(4):327-337.
[15] 王晓敏,赵燕,陈楠,等.唾液测试板检测口腔幽门螺杆菌的实用性研究[J].华西口腔医学杂志,2012,30(5):501-504.
[16] Cervantes DT,Fischbach LA,Goodman KJ,et al.Exposure to Helicobacter pylori-positive siblings and persistence of Helicobacter pylori infection in early childhood[J].J Pediatr Gastroenterol Nutr,2010,50(5):481-485.
[17] Liu P,Yue J,Chen D,et al.A cross-sectional survey of dental caries,oral hygiene,and Helicobacter pylori infection in adults[J].Asia Pac J Public Health,2013,25(4 S):49-56.
[18] Johannes GK,Arnoud HMV,Ernst J.Kuipers.Pathogenesis of helicobacter pylori infection [J].Clin Microbiol Rev,2006,19:449-490.
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