目的 研究被动吸烟孕妇血浆白细胞介素6(interleukin-6,IL-6)和白细胞介素10(interleukin-10,IL-10)在孕期的变化,探讨其与早产之间的关系。方法 选取155例早产孕妇(28~36+6周)为研究组,并根据有无存在被动吸烟分成两组,研究组1为被动吸烟组,研究组2在妊娠期间无被动吸烟或吸烟;同时选取82例对照组孕妇(妊娠期无被动吸烟或吸烟且最后足月分娩的产妇)。采用酶联免疫吸附法,测定研究组1、2孕妇及对照组孕妇在相应孕周时的血浆IL-6和IL-10浓度。结果 研究组1孕妇血浆IL-6浓度较研究组2和对照组明显升高(P<0.05);而研究组1孕妇IL-10浓度较在研究组2降低,但其变化无显著意义(P>0.05);研究组孕妇IL-10较对照组明显下降(P<0.05)。结论 孕期被动吸烟可致IL-6明显升高,及IL-10呈下降趋势,可能参与了被动吸烟引发早产高风险的机制,增加早产的发生风险。
Abstract
Objective To study pregnancy changes of plasma interleukin-6 (IL-6) and interleukin-10 (IL-10) in the passive smoking pregnant women to explore it's relationship with premature. Methods According to the exist of passive smoking,155 cases of premature pregnant (28~36+6 weeks) of study group were divided into two groups,study group 1 as passive smoking group,study group 2 during pregnancy without passive smoking or smoking; and 82 cases of pregnant women were selected as the control group (no passive smoking or smoking during pregnancy and the final normal term labor).Maternal plasma IL-6 and IL-10 concentrations were tested by enzyme-linked immunosorbent assay during 28~36+6 weeks' gestation. Results Maternal plasma IL-6 concentration of study group 1 were significantly higher than that of study group 2 and control group(P<0.05);But maternal plasma IL-10 concentration of study group 1 was lower than that of the study group 2,but had no significant difference(P>0.05);and maternal plasma IL-10 concentration of study group was significantly lower than that of control group(P<0.05). Conclusion Passive smoking during pregnancy can cause IL-6 increased significantly,and IL-10 decreased,which may participate in the mechanism of passive smoking causing premature high-risk,to increase the risk of preterm delivery.
关键词
被动吸烟 /
白细胞介素-6 /
白细胞介素-10 /
早产
Key words
passive smoking /
interleukin-6 /
interleukin-10 /
premature
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