目的 探讨佛山市南海区0～6岁儿童25-羟基维生素D[25-(OH)D]营养状况与年龄、季节的关系,为指导儿童合理补充维生素D提供科学依据。方法 收集2014年在佛山市南海区妇幼保健院儿保科体检的5 017名儿童的清晨空腹静脉血,采用高效液相色谱-串联质谱仪检测血清25-(OH)D水平。结果 2014年佛山市南海区5 017名0～6岁儿童25-(OH)D平均水平为69.07 nmol/L,VitD严重缺乏0.09%,缺乏18.71%,不足31.01%,充足50.16%。检测水平随着年龄的增长而降低(P＜0.05),夏秋季节高于春冬季节(P＜0.05)。结论 南海区儿童25-(OH)D水平偏低,建议强化维生素D补充剂可从新生儿期一直持续至儿童、青少年阶段。

Objective To understand the nutritional status of 25-hydroxy vitamin D[25-(OH)D] and the relationships with age and season in 0~6 years old children in Nanhai district of Foshan city. Methods A total of 5 017 children aged 0~6 years old for physical examination in Nanhai Maternal and Child Health Care Hospital in 2014,and venous blood samples were collected from subjects before breakfast in the morning.Their test results of 25-(OH)D were detected by the high efficiency liquid chromatography- tandom mass spectrometer. Results The average level of 25-(OH)D was 69.07 nmol/L in 5 017 children aged 0~6 years old in Nanhai District in 2014.The percentage of 25-(OH)D famine was 0.09%.The percentage of 25-(OH)D deficiency was 18.71%.The percentage of 25-(OH)D insufficient was 31.01%.The percentage of 25-(OH)D sufficient was 50.16%.The detection level decreased with age(P＜0.05).The detection level of summer and autumn was higher than that in spring and winter(P＜0.05). Conclusions The level of 25-(OH)D in children in Nanhai district is low.Vitamin D preparation can be supplement from the neonatal period until the child and adolescent stage.