目的 应用Meta分析系统评价黑色素皮质激素第四受体基因(melanocortin-4 receptor gene,MC4R) rs17782313与儿童肥胖易感性的关系,以得到更有说服力的结论。方法 利用计算机检索数据库PubMed,中国知网、万方等,手工检索纳入文献的参考文献。采用STATA 11.0软件进行Meta分析。利用随机效应模型或固定效应模型计算其合并比值比(OR)和95%可信区间(95%CI),以及合并加权均数差(WMD)的值。结果 共有12个研究纳入研究,其中在纯合子模型(OR=1.84,95%CI:1.44~2.36,Phet=0.001)、杂合子模型(OR=1.48,95%CI:1.29~1.70,Phet=0.756)、显性模型(OR=1.67,95%CI:1.39~1.99,Phet=0.082)和隐性模型(OR=1.35,95%CI:1.19~1.55,Phet=0.000),差异均有统计学意义。在基因型与体质指数(body mass index,BMI)Z-score定量关联性分析中,发现rs17782313T>C的突变会影响儿童的BMI Z-score(WMD=0.14,95%CI:0.06~0.23,CC vs TT)。结论 Meta分析研究结果证实了MC4R rs17782313与儿童肥胖的关系。
Abstract
Objective To apply a Meta-analysis of various studies from different ethnic populations and assess the association of the melanocortin 4 receptor(MC4R) polymorphism with childhood obesity. Methods All published literature were retrieved that investigated association of MC4R variants with obesity from PubMed,CNKI and Wanfang database.Pooled odds ratio (OR) with 95% confidence interval (CI) and weighted mean difference (WMD) were calculated using fixed- or random-effects model. Results A total of 12 case-control studies were eligible for this analysis.Meta-analysis showed that MC4R rs17782313 increased the risk of childhood obesity in all models (CC vs TT,OR=1.84,95%CI:1.44~2.36;CC vs CT,OR=1.48,95%CI:1.29~1.70,Phet=0.756;CC vs TT/TC,OR=1.67,95%CI:1.39~1.99;TC/CC vs TT,OR=1.35,95%CI:1.19~1.55).Moreover,the association between genotypes and childhood the body mass index (BMI) Z-score was also significant (WMD=0.14,95%CI:0.06~0.23,CC vs TT). Conclusion The present meta-analysis confirms the association of MC4R polymorphism with risk of childhood obesity.
关键词
MCR4 /
基因多态性 /
儿童 /
肥胖 /
Meta分析
Key words
melanocortin 4 receptor /
polymorphism /
children /
obesity /
Meta-analysis
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参考文献
[1] Hill JO,Peters JC.Environmental contributions to the obesity epidemic[J].Science,1998,280:1371-1374.
[2] Hossain P,Kawar B,Nahas ME.Obesity and diabetes in the developing world--a growing challenge[J].N Engl J Med,2007,356(3):213-215.
[3] De Castro JM,Lilenfeld LR.Influence of heredity on dietary restraint,disinhibition,and perceived hunger in humans[J].Nutrition,2005,21(4):446-455.
[4] Loos RJ,Lindgren CM,Li S,et al.Common variants near mc4r are associated with fat mass,weight and risk of obesity[J].Nat Genet,2008,40(6):768-775.
[5] Qi L,Kraft P,Hunter DJ,et al.The common obesity variant near mc4r gene is associated with higher intakes of total energy and dietary fat,weight change and diabetes risk in women[J].Hum Mol Genet,2008,17(22):3502-3508.
[6] Webber L,Hill C,Saxton J,et al.Eating behaviour and weight in children[J].Int J Obes(Lond),2009,33(1):21-28.
[7] Yang CW,Li CI,Liu CS,et al.The joint effect of cigarette smoking and polymorphisms on lrp5,lepr,near mc4r and sh2b1 genes on metabolic syndrome susceptibility in taiwan[J].Mol Biol Rep,2013,40(1):525-533.
[8] Zhao X,Xi B,Shen Y,et al.An obesity genetic risk score is associated with metabolic syndrome in chinese children[J].Gene,2014,535(2):299-302.
[9] Zlatohlavek L,Vrablik M,Motykova E,et al.FTO and mc4r gene variants determine bmi changes in children after intensive lifestyle intervention[J].Clin Biochem,2013,46(4-5):313-316.
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