目的 建立以人群为基础的胎龄别新生儿出生头围百分位数修匀曲线。方法 采用横断面调查的方法对北京市顺义区医院及顺义区妇幼保健院2009年11月1日-2011年1月21日间出生的新生儿进行体格指标的标准化测量,并进行严格的质量控制。采用偏度-中位数-变异系数法(LMS)对不同胎龄新生儿出生头围百分位数进行修匀,得到修匀后的参考曲线,并与1986-1987年中国15市新生儿体格发育调查结果进行比较。结果 共5 201例符合标准的研究对象纳入分析,获得了顺义区新生儿胎龄别出生头围的修匀曲线。37~41周的胎龄别出生头围,男婴比女婴的头围大0.3~0.4 cm,差异具统计学意义(P<0.05)。本研究测得的胎龄别出生头围均低于1986-1987年中国15市新生儿体格发育调查结果。结论 本研究建立了北京市顺义区胎龄别新生儿出生头围百分位数修匀长曲线,为该地区及其它类似地区评估胎儿生长发育提供了较新的参考依据。

Objective To establish population-based percentile curves for gestational-age specific head circumference of newborns. Methods Data were collected from November 1^st 2009 to January 21^st 2011 in Shunyi District Hospital of Beijing and Shunyi Maternal and Child Health Hospital.All newborns who were born in these two hospitals were taken standard physical measurements.Strict quality control was essential for assurance of the quality of data.LMS program was used to smooth the percentile curve.And the results with investigation results of 15 cities of China in 1986-1987 were also compared. Results A total of 5 201 subjects were engaged.Percentiles at P₃,P₁₀,P₂₅,P₅₀,P₇₅,P₉₀,P₉₇ of head circumference were calculated,and the corresponding reference curves for gestational age-specific and gender-specific were successfully smoothed.Differences of head circumference between boys and girls were significant at 37~41 weeks,head circumference values were higher in boys.But our measurements were lower than the investigation results of 15 cities of China in 1986-1987. Conclusion Gestational age-specific and gender-specific percentiles are presented in this study.And it would be proposed a current reference for the local clinicians and researchers to evaluate fetal growth.