目的 探讨急性白血病患儿的睡眠紊乱与疲乏的相关性。方法 采用便利抽样选取65名急性白血病儿童病例,对其主要照顾者进行问卷调查,内容包括儿童睡眠紊乱量表(Sleep Disturbance Scale for Children,SDSC)和PedsQL TMMFS儿童多维疲乏量表。结果 急性白血病患儿的睡眠量表总分为(47.83±10.74)分,睡眠紊乱总发生率为6.15%,各维度中睡眠-觉醒转换障碍和睡眠呼吸障碍和觉醒障碍发生率最高。疲乏总分为(60.41±17.26)分,三个维度得分由低到高依次为一般疲乏、休息疲乏和认知疲乏。患儿的睡眠紊乱与疲乏呈负相关(r=-0.51,P<0.01),即患儿睡眠紊乱越严重,疲乏程度越高。结论 急性白血病患儿治疗期间最常见的睡眠紊乱为睡眠-觉醒转换障碍和睡眠呼吸障碍和觉醒障碍,疲乏主要表现为一般疲乏和休息疲乏。急性白血病患儿的睡眠障碍与疲乏状况呈负相关。
Abstract
Objective To explore the correlation of sleep disturbances and fatigue among children with acute leukemia. Methods The main caregivers of 65 children with acute leukemia were surveyed on the Sleep Disturbance Scale for Children (SDSC) and the Pediatric Quality of Life Inventory TM (PedsQL TM) Multidimensional Fatigue Scale (MFS) (Parent Investigation Questionnaire). Results The total score of SDSC scale was (47.83±10.74) on average.The prevalence of sleep disorders of children with acute leukemia was 6.15%.Sleep-wake transition disorders,sleep breathing disorders,and disorders of arousal were the first three common disorders.The total score of PedsQL TMMFS was (60.41±17.26) on average.The ascending order of the three dimensions' score was general fatigue,sleep fatigue and cognitive fatigue.The total score of sleep disturbances was negatively correlated with that of fatigue (r=-0.51,P<0.001),which meaned that the more serious the sleep disturbance was,the more serious the fatigue was. Conclusions The most common sleep disturbances of children with acute leukemia in hospital are sleep-wake transition disorders,sleep breathing disorders,and disorders of arousal.General fatigue and sleep fatigue are the main manifestations of fatigue.Sleep disturbances and fatigue are negatively correlated with each other.
关键词
急性白血病 /
睡眠紊乱 /
疲乏 /
患儿
Key words
acute leukemia /
sleep disturbances /
fatigue /
children
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
[1] Pui CH,Carroll WL,Meshinchi S,et al.Biology,risk stratification,and therapy of pediatric acute leukemias:an update[J].J Clin Oncol,2011,29(5):551-565.
[2] Hockenberry MJ,Hooke MC,Gregurich M,et al.Symptom clusters in children and adolescents receiving cisplatin,doxorubicin,or ifosfamide[J].Oncol Nurs Forum,2010,37(1):e16-27.
[3] Bruni O,Ottaviano S,Guidetti V,et al.The Sleep Disturbance Scale for Children (SDSC) Construction and validation of an instrument to evaluate sleep disturbances in childhood and adolescence[J].J Sleep Res,1996,5(4):251-261.
[4] Romeo DM,Bruni O,Brogna C,et al.Application of the sleep disturbance scale for children (SDSC) in preschool age[J].Eur J Paediatr Neurol,2013,17(4):374-382.
[5] Huang MM,Qian Z,Wang J,et al.Validation of the Sleep Disturbance Scale for Children and prevalence of parent-reported sleep disorder symptoms in Chinese children[J].Sleep Med,2014,15(8):923-928.
[6] Guillemin F,Bombardier C,Beaton D.Cross-cultural adaptation of health-related quality of life measures:literature review and proposed guidelines[J].J Clin Epidemiol,1993,46(12):1417-1432.
[7] Varni JW,Burwinkle TM,Katz ER,et al.The PedsQL in pediatric cancer:reliability and validity of the Pediatric Quality of Life Inventory Generic Core Scales,Multidimensional Fatigue Scale,and cancer module[J].Cancer,2002,94(7):2090-2106.
[8] Varni JW,Limbers CA,Bryant WP,et al.The PedsQL?Multidimensional Fatigue Scale in pediatric obesity:Feasibility,reliability,and validity[J].International Journal of Pediatric Obesity,2010,5(1):34-42. [9] Panepinto JA,Torres S,Bendo CB,et al.PedsQLim Multidimensional Fatigue Scale in sickle cell disease:Feasibility,reliability and validity[J].Pediatric Blood & Cancer,2014,61(1):171-177. [10] Varni JW,Beaujean A,Limbers CA.Factorial invariance of pediatric patient self-reported fatigue across age and gender:A multigroup confirmatory factor analysis approach utilizing the PedsQLTM Multidimensional Fatigue Scale[J].Quality of Life Research,2013,22(9):2581-2594.
[11] Kaleyias J,Manley P,Kothare SV.Sleep disorders in children with cancer[J].Semin Pediatr Neurol,2012,19(1):25-34.
[12] Hockenberry-Eaton M,Hinds PS,Alcoser P,et al.Fatigue in children and adolescents with cancer[J].Journal of pediatric Oncology Nursing,1998,15(3):172-182.
[13] Gordijn MS,van Litsenburg RR,Gemke RJ,et al.Sleep,fatigue,depression,and quality of life in survivors of childhood acute lymphoblastic leukemia[J].Pediatr Blood Cancer,2013,60(3):479-485.
基金
2013年广东省医学科研基金立项课题(A2013179)
PDF(454 KB)
