目的 系统探讨儿童急性淋巴细胞白血病(acute lymphoblastic leukemia, ALL)与出生体重的关联性。方法 计算机检索Medline、PubMed、Web of Science、Cochrane Library等英文数据库收集相关文献, 检索时间截止到2014年。检索关键词为“acute lymphoblastic leukemia”、“childhood”、“birth weight”, 对纳入文献提取相关资料并进行质量评价。通过STATA12.0软件对提取的数据进行meta分析, 计算比值比OR及95%置信区间, 并进行异质性、敏感性和发表偏倚的统计分析。结果 本次研究共纳入文献16篇, 包括16 934例病例和54 733例对照。Meta分析结果显示儿童ALL与出生体重之间存在关联性[≥2 500 g vs <2 500 g(OR=0.17, 95%CI=1.07~1.28)、≥3 500 g vs <3 500 g(OR=1.12, 95%CI=1.04~1.22)、≥4 000 g vs <4 000 g(OR=1.20, 95%CI=1.12~1.27)、≥4 500 g vs <4 500 g(OR=1.27, 95%CI=1.09~1.47)]。结论 儿童ALL与出生体重存在关联性, 较大的出生体重是儿童ALL的危险因素。
Abstract
Objective To explore the association between birth weight and the risk of childhood acute lymphoblastic leukemia (ALL). Methods The studies were searched through Medline, PubMed, Web of Science, Cochrane Library, and the retrieving deadline was 2014.Search terms included "acute lymphoblastic leukemia", "childhood", "birth weight".The information of birth weight was extracted, and the quality of the studies was evaluated.STATA12.0 software package was used to calculate the OR and CI 95%, heterogeneity, sensitivity and publication bias of the Meta-analysis. Results A total of 16 studies included 16 934 childhood ALL case and 54 733 control were identified.The Results suggested that there was association between birth weight and the risk of childhood acute lymphoblastic leukemia[≥2 500 g vs <2 500 g(OR=1.17, 95%CI=1.07~1.28), ≥3 500 g vs <3 500 g(OR=1.12, 95%CI=1.04~1.22), ≥4 000 g vs <4 000 g(OR=1.20, 95%CI=1.12~1.27), ≥4 500 g vs <4 500 g(OR=1.27, 95%CI=1.09~1.47)]. Conclusion There is association between birth weight and the risk of childhood acute lymphoblastic leukemia, and the high birth weight is the risk factor of childhood acute lymphoblastic leukemia.
关键词
儿童急性淋巴细胞白血病 /
出生体重 /
Meta分析
Key words
childhood acute lymphoblastic leukemia /
birth weight /
Meta-analysis
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参考文献
[1] Wünsch-Filho V, Pelissari DM, Barbieri FE, et al.Exposure to magnetic fields and childhood acute lymphocytic leukemia in Sao Paulo, Brazil[J].Cancer Epidemiology, 2011, 35(6):534-539.
[2] Bailey HD, Milne E, de Klerk NH, et al.Exposure to house painting and the use of floor treatments and the risk of childhood acute lymphoblastic leukemia[J].International Journal of Cancer, 2011, 128(10):2405-2414.
[3] Zhao L, Liu X, Wang C, et al.Magnetic fields exposure and childhood leukemia risk:A meta-analysis based on 11, 699 cases and 13, 194 controls[J].Leukemia Research, 2014, 38(3):269-274.
[4] Chokkalingam AP, Metayer C, Scelo GA, et al.Variation in xenobiotic transport and metabolism genes, household chemical exposures, and risk of childhood acute lymphoblastic leukemia[J].Cancer Causes & Control, 2012, 23(8):1367-1375.
[5] Hjalgrim LL, Rostgaard K, Hjalgrim H, et al.Birth weight and risk for childhood leukemia in Denmark, Sweden, Norway, and Iceland[J].Journal of the National Cancer Institute, 2004, 96(20):1549-1556.
[6] Canfield KN, Spector LG, Robison LL, et al.Childhood and maternal infections and risk of acute leukaemia in children with Down syndrome:a report from the Children's Oncology Group[J].British Journal of Cancer, 2004, 91(11):1866-1872.
[7] Spector L, Groves F, DeStefano F, et al.Medically recorded allergies and the risk of childhood acute lymphoblastic leukaemia[J].European Journal of Cancer, 2004, 40(4):579-584.
[8] Jourdan-Da Silva N, Perel Y, Méchinaud F, et al.Infectious diseases in the first year of life, perinatal characteristics and childhood acute leukaemia[J].British Journal of Cancer, 2004, 90(1):139-145.
[9] Kwan ML, Buffler PA, Wiemels JL, et al.Breastfeeding patterns and risk of childhood acute lymphoblastic leukaemia[J].British Journal of Cancer, 2005, 93(3):379-384.
[10] Ma X, Does MB, Metayer C, et al.Vaccination history and risk of childhood leukaemia[J].International Journal of Epidemiology, 2005, 34(5):1100-1109.
[11] Petridou E, Ntouvelis E, Dessypris N, et al.Maternal diet and acute lymphoblastic leukemia in young children[J].Cancer Epidemiology Biomarkers & Prevention, 2005, 14(8):1935-1939.
[12] Kamper-Jorgensen M, Woodward A, Wohlfahrt J, et al.Childcare in the first 2 years of life reduces the risk of childhood acute lymphoblastic leukemia[J].Leukemia, 2007, 22(1):189-193.
[13] Sprehe MR, Barahmani N, Cao Y, et al.Comparison of birth weight corrected for gestational age and birth weight alone in prediction of development of childhood leukemia and central nervous system tumors[J].Pediatric Blood & Cancer, 2010, 54(2):242-249.
[14] Urayama KY, Ma X, Selvin S, et al.Early life exposure to infections and risk of childhood acute lymphoblastic leukemia[J].International Journal of Cancer, 2011, 128(7):1632-1643.
[15] Oksuzyan S, Crespi CM, Cockburn M, et al.Birth weight and other perinatal characteristics and childhood leukemia in California[J].Cancer Epidemiology, 2012, 36(6):e359-e365.
[16] Zierhut H, Linet MS, Robison LL, et al.Family history of cancer and non-malignant diseases and risk of childhood acute lymphoblastic leukemia:A children's group cancer[J].Epidemiol, 2012, 36(1):45-51.
[17] Roman E, Lightfoot T, Smith A G, et al.Childhood acute lymphoblastic leukaemia and birthweight:Insights from a pooled analysis of case-control data from Germany, the United Kingdom and the United States[J].European Journal of Cancer, 2013, 49(6):1437-1447.
[18] Rudant J, Amigou A, Orsi L, et al.Fertility treatments, congenital malformations, fetal loss, and childhood acute leukemia:The ESCALE study (SFCE)[J].Pediatric Blood & Cancer, 2013, 60(2):301-308.
[19] Diamantaras AA, Dessypris N, Sergentanis TN, et al.Nutrition in early life and risk of childhood leukemia:a case-control study in Greece[J].Cancer Causes & Control, 2013, 24(1):117-124.
[20] Lariou MS, Dikalioti SK, Dessypris N, et al.Allergy and risk of acute lymphoblastic leukemia among children:A nationwide case control study in Greece[J].Cancer Epidemiology, 2013, 37(2):146-151.
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