生长激素缺乏症对心血管系统的影响

张文化 综述, 李国林 审校

中国儿童保健杂志 ›› 2015, Vol. 23 ›› Issue (4) : 371-373.

PDF(423 KB)
PDF(423 KB)
中国儿童保健杂志 ›› 2015, Vol. 23 ›› Issue (4) : 371-373. DOI: 10.11852/zgetbjzz2015-23-04-11
综述与讲座

生长激素缺乏症对心血管系统的影响

  • 张文化 综述, 李国林 审校
作者信息 +
文章历史 +

摘要

生长激素缺乏症(growth hormone deficiency,GHD)是由于腺垂体合成和分泌生长激素(growth hormone,GH)部分或完全缺乏,或是由于GH分子结构异常、或受体缺陷等导致的生长发育障碍性疾病。文献报道GHD会增加心血管疾病的发病率、死亡率,导致机体心脏结构及功能损害、脂质代谢异常,内皮细胞功能紊乱,危害机体健康。本文就近年来GHD对心血管系统的影响进行综述。

关键词

生长激素缺乏症 / 生长激素 / 心血管系统 / 脂质代谢

引用本文

导出引用
张文化 综述, 李国林 审校. 生长激素缺乏症对心血管系统的影响[J]. 中国儿童保健杂志. 2015, 23(4): 371-373 https://doi.org/10.11852/zgetbjzz2015-23-04-11
中图分类号: R725.4   

参考文献

[1] Holdaway IM.Excess mortality in acromegaly[J].Horm Res,2007,68(S):166-172.
[2] Holscher C.The role of GLP-1in neuronal activity and neurodegeneration[J].Vitam Horm,2010,84:331-354.
[3] Pfeifer AC,Timmer J,Klingmuller U.Systems biology of JAK/STAT signaling[J].Essays Biochem,2008,45:109-120.
[4] Katsumata N.Growth hormone-binding protein(GHBP)[J].Nippon Rinsho,2010,68:200-202.
[5] Colao A.The GH-IGF-1 axis and the cardiovascular system:clinical implications[J].Clin Endocrinol,2008,69(3):347-358.
[6] Verhelst J,Abs R.Cardiovascular risk factors in hypopituitary GH-deficient adults[J].Eur J Endocrinol,2009,161(S):41-49.
[7] Capalbo D,Esposito A,Di Mase R,et al.Update on early cardiovascular and metabolic risk factors in children and adolescents affected with growth hormone deficiency[J].Minerva Endocrinologica,2012,37(4):379-389.
[8] Montagnana M,Lippi G,Danese E,et al.The role of osteoprotegerin in cardiovascular disease[J].Ann Med,2013,45(3):254-264.
[9] Andreassen M.The growth hormone/insulin-like growth factor-1 system in chronic heart failure and its interaction with adiponectin[J].Eur J Heart Fail,2010,12(11):1154-1155.
[10] Schneider HJ,Klotsche J,Wittchen HU,et al.Effects of growth hormone replacement within the KIMS survey on estimated cardiovascular risk and predictors of risk reduction in patients with growth hormone deficiency[J].Clin Endocrinol,2011,75(6):825-830.
[11] Groban L,Lin M,Kassik KA,et al.Early-onset growth hormone deficiency results in diastolic dysfunction in adult-life and is prevented by growth hormone supplementation[J].Growth Hormone & IGF Res,2011,21(2):81-88.
[12] Colao A,Di Somma C,Cuocolo A,et al.The severity of growth hormone deficiency correlates with the severity of cardiac impairment in 100 adult patients with hypopituitarism:an observational,case-control study[J].Clin Endocrinol Metab,2004,89(12):5908-6004.
[13] Cenei MC,Soares DV,Spina LD,et al.Effeets of 5years of growth hormone(GH) replacement therapy on cardiac parameters and physical performance in adults with GH deficiency[J].Pituitary,2009,12(4):322-329.
[14] Donatella C,Andrea LV.Subtle alterations of cardiac performance in children with growth hormone deficiency:results of a two-year prospective,case-control study[J].Clin Endocrinol Metab,2009,94(9):3347-3355.
[15] Chrisoulidou A,Beshyah SA,Rutherford O,et al.Effects of 7 years of growth hormone replacement therapy in hypopituitary adults[J].Clin Endocrinol Metab,2000,85(10):3762-3769.
[16] Jorgensen AP,Fougner KJ,Ueland T,et al.Favorable long-term effects of growth hormone replacement therapy on quality of life,bone metabolism,body composition and lipid levels in patients with adult-onset growth hormone deficiency[J].Growth Hormone & IGF Res,2011,21(2):69-75.
[17] Kotb AM,Hekma SF,Heba AAE.Evaluation of left ventricular mass and function,lipid profile and insulin resistance in Egyptian children with growth hormone deficiency:A single-center prospective case-control study[J].Endocrinol Metab,2013,17(5):876-882.
[18] Christ ER,Cummings MH,Jackson N,et al.Effects of growth hormone (GH) replacement therapy on low-density lipoprotein apolipoprotein B100 kinetics in adult patients with GH deficiency:a stable isotope study[J].Clin Endocrinol Metab,2004,89(4):1801-1807.
[19] Miller KK,Wexler T,Fazeli P,et al.Growth hormone deficiency after treatment of acromegaly:a randomized,placebo-controlled study of growth hormone replacemen[J].Clin Endocrinol Metab,2010,95 (2):567-577.
[20] Mikkel A,Jens F,Andreas K,et al.Cardiac function in growth hormone deficient patients before and after 1 year with replacement therapy:a magnetic resonance imaging study[J].Pituitary,2011,14(1):1-10.
[21] Colao A,Di Somma C,Rota F,et al.Common carotid intima-media thickness in growth hormone (GH)-deficient adolescents:a prospective study after GH withdrawal and restarting GH replacement[J].Clin Endocrinol Metab,2005,90(5):2659-2665.
[22] Makimura H,Stanley T,Mun D,et al.Reduced growth hormone secretion is associated with increased carotid intima-media thickness in obesity[J].Clin Endocrinol Metab,2009,94(12):5131-5138.
[23] Lanes R,Soros A,Flores K,et al.Endothelial function,carotid artery intima-media thickness,epicardial adipose tissue,and left ventricular mass and function in growth hormone-deficient adolescents:apparent effects of growth hormone treatment on these parameters[J].Clin Endocrinol Metab,2005,90(7):3978-3982.
[24] Van der Klaauw AA,Pereira AM,Rabelink TJ,et al.Recombinant human GH replacement increases CD34+ cells and improves endothelial function in adults with GH deficiency[J].Eur J Endocrinol,2008,159(2):105-111.
[25] Oliveira JL,Aguiar Oliveira MH,D'Oliveira AJ,et al.Congenital growth hormone (GH) deficiency and atherosclerosis:effects of GH replacement in GH-naive adults[J].Clin Endocrinol Metab,2007,92(12):4664-4670.

PDF(423 KB)

Accesses

Citation

Detail

段落导航
相关文章

/