目的 研究补充n-3多不饱和脂肪酸(n-3PUFA)鱼油制剂对哮喘患儿肺通气功能和血清细胞因子的影响。方法 选择西安交通大学第二附属医院儿童哮喘专病门诊就诊的哮喘患儿分为观察组46例、对照组26例,观察组在给予哮喘常规治疗的基础上每日补充n-3 PUFA鱼油制剂16周,分别检测治疗前后呼出气肺功能FEV1、PEF和FeNO的变化以及血清细胞因子IL-4、IL-5、IFN-γ、TGF-β1的水平变化,并对检测结果进行分析。结果 与对照组相比,补充n-3 PUFA鱼油制剂组在治疗16周后肺功能指标FEV1%、PEF%明显增高(P<0.01),FeNO水平明显降低(P<0.01),而患儿血清IL-4、 IL-5、TGF-β1水平明显降低(P<0.05 ),IFN-γ增高,但差异无统计学意义(P＞0.05)。结论 补充n-3 PUFA鱼油制剂可提高哮喘患儿肺通气功能,影响细胞因子水平变化,具有减轻哮喘儿童气道炎症。
Abstract
Objective To explore the effect of the expression of n-3 PUFA supplementation on pulmonary ventilation function,exhaled nitric oxide(FeNO) and cytokine production of children with asthma. Methods Children with asthma were randomly divided into two groups:treatment group (46 cases) and conventional group (26 cases).The conventional group was treated with conventional methods.The treatment group was given additional n-3PUFA supplementation besides conventional treatment.FEV1%,PEF%,FeNO and IL-4,IL-5,IFN-γ,TGF-β1 in the serum were measured before and after the treatmen. Results Compared with conventional group,the FEV1%,PEF% increased significantly (P<0.01) and FeNO decreased (P<0.01) among treatment group after the treatment.The concentration of IL-4,IL-5,TGF-β1 decreased,and that of IFN-γ increased in the serum of asthma children with before and after the treatment. Conclusion The n-3PUFA can remarkably improves ventilation,reduce airway inflammation in children with asthma.
关键词
n-3PUFA /
呼出气一氧化碳 /
细胞因子 /
儿童哮喘
Key words
n-3PUFA /
exhaled nitric oxide /
cytokines /
children asthma
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
[1] Mickleborough TD,Lindley MR,Alina AI,et al.Protective effect of fish oil supplementation on exercise-induced bronchoconstriction in asthma[J].Chest,2006,129:39-49.
[2] 中华医学会儿科学分会呼吸学组,《中华儿科杂志》编辑委员会.儿童支气管哮喘诊断与防治指南[J].中华儿科杂志,2008,46(10):745-753.
[3] Silverman ES,Le L,Baron RM,et al.Cloning and functional analysis of the mouse 5-lipoxygenase promoter[J].Am J Respir Cell Mol Biol,2002,26(4):475-483.
[4] Lin PY,Su KP.A meta-analytic review of double-blind,placebo-controlled trials of antidepressant efficacy of omega-3 fatty acids[J].Journal of Clinical Psychiatry,2007,68(7):1056-1061.
[5] Oddy WH,de Klerk NH,Kendall GE,et al.Ratio omega-6 to omega-3 fatty acids and childhood asthma[J].Joural of Asthma,2004,1(3):319-326.
[6] 王强,罗运春,周晓聪,等.n-3 多不饱和脂肪酸对哮喘小鼠白三烯B4 及5 脂氧合酶基因表达的影响[J].实用医学杂志,2007,23 (8):1131-1133.
[7] 黄汉,陈镇新,甘慧鱼.油制剂对运动诱发性哮喘的预防作用[J].中国实用医药杂志,2009,24(17):159-161.
[8] 赵飞,乔艳红,刘丰,等.鱼油补充对哮喘儿童肺通气功能影响[J].中国公共卫生,2008,24(7):780-781.
[9] 侯伟,刘海燕,王爱荣.氧化苦参碱对小鼠哮喘模型气道炎症及细胞因子的影响[J].西安交通大学学报:医学版,2004,25(6):587-589.
[10] Makinde T,Murphy RF,Agrawal DK.The regulatory role of TGF-β in airway remodeling in asthma[J].Immunology and Cell Biology,2007,85(5):348-356.
[11] 侯伟,刘海燕,杨旭东,等.氧化苦参碱对哮喘小鼠肺组织中TGF-β1及AngII表达的影响[J].中国儿童保健杂志,2010,18(2):135-137.
基金
北京有孚伟业经贸有限公司资助项目(2012-01)
PDF(420 KB)
