目的 腹型肥胖则是一系列代谢紊乱的始动因素,本研究的目的是研究腹型肥胖与体内炎性因子水平及代谢综合征(metabolic syndrome,MS)之间的关系,为儿童肥胖尤其是腹型肥胖的治疗提供一定理论依据。方法 选取2011-2012年于西安交通大学第二附属医院儿科内分泌门诊就诊的单纯性肥胖儿童85例,根据腰围将其分为腹型肥胖组及非腹型肥胖组。测量研究对象的身高,体重,腰围及臀围;抽取空腹血并检测血脂,血糖以及超敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)及内脂素水平。结果 腹型肥胖患儿体质指数(body mass index,BMI)、腰围、腰臀比均显著高于非腹型肥胖患儿(P均＜0.05);腹型肥胖组MS检出率显著高于非腹型肥胖组(P＜0.05);腹型肥胖患儿与非腹型肥胖患儿比较,高血压、高血糖、高TG血症、低HDL-C血症的患病人数在两组间差异均具有统计学意义(P＜0.05);腹型肥胖患儿血清中hs-CRP及内酯素的水平均显著高于非腹型肥胖组。结论 腹型肥胖儿童比非腹型肥胖儿童更容易患MS,儿童腹部脂肪分布与甘油三酯及体内炎症因子增高关系较为密切。因此,应积极防治肥胖,尤其是腹型肥胖。
Abstract
Objective Abdominal obesity is the initial factor of a series of metabolic disorders,therefore,the aim was to study the relation between abdominal obesity and inflammatory factor level,metabolic syndrome,and to provide the theoretical basis for the treatment of abdominal obesity. Methods A total of 85 cases of obese children were as subjects who were from the pediatric endocrine clinic of the Second Affiliated Hospital of Xi'an Jiaotong University from 2011 to 2012.According to the waist circumference,subjects were divided into abdominal obesity group and non-abdominal obesity group.Objects' height,weight,waist circumference and hip circumference were measured,fasting blood glucose,blood lipid,hs-CRP and visfatin levels were detected too. Results Body mass index(BMI),waist circumference,waist to hip ratio of abdominal obese children were significantly higher than those of non abdominal obese children (P<0.05);Abdominal obesity group of metabolic syndrome prevalence was higher than that in non abdominal obesity group (P<0.05);Comparison of children with abdominal obesity with non abdominal obesity,prevalence of hypertension,high blood sugar,high TG level and low HDL-C level had a statistical difference between the two groups;The level of C-reactive protein and visfatin levels were significantly higher than those in non abdominal obesity group. Conclusions Abdominal obesity children than non abdominal obesity are more likely to develop metabolic syndrome,and children with abdominal fat distribution more closely related to triglyceride and body inflammatory cytokines increased.Therefore,obesity,especially abdominal obesity should be actively prevented and controled.
关键词
腹型肥胖 /
儿童 /
炎症因子 /
代谢综合征
Key words
abdominal obesity /
children /
inflammatory factors /
metabolic syndrome
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参考文献
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基金
国家自然科学基金(81172689);西安交通大学附属二院重大科研方向资助计划[YJ(ZDJH)201303(3)]
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