地中海贫血患儿维生素D水平及影响因素分析

李仕勇; 陈一菁; 邹金林; 班克创; 陈剑锋

doi:10.11852/zgetbjzz2015-23-02-03

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中国儿童保健杂志 ›› 2015, Vol. 23 ›› Issue (2) : 119-122. DOI: 10.11852/zgetbjzz2015-23-02-03

科研论著

地中海贫血患儿维生素D水平及影响因素分析

李仕勇¹，陈一菁²，邹金林¹，班克创¹，陈剑锋²

作者信息 +

Analysis of status and possible risk factors of vitamin D deficiency in children with thalassemia.

LI Shi-yong¹,CHEN Yi-jing²,ZOU Jin-lin¹,BAN Ke-chuang¹,CHEN Jian-feng².

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摘要

目的了解我国地中海贫血儿童维生素D(vitamin D，Vit D)水平状况。方法 81例各型地中海贫血患儿纳入研究，收集临床资料，计算体质指数Z分值(body mass index Z-score，BMI-Z分值);测定血清25-(OH)D、钙和磷水平;采用PCR-RFLP方法分析Vit D受体(vitamin D receptor，VDR)基因Fok I、Bsm I、Apa I位点多态性。结果地中海贫血患儿25-(OH)D水平为(23.7±9.2)ng/mL，显著低于对照组的(28.3±10.5)ng/mL(P<0.05);地中海贫血合并Vit D缺乏或不足的发生率为66.7%，比对照组高;重型地中海贫血Vit D缺乏或不足者检出率88.9%，中间型64.0%，轻型48.3%。所有患儿血清钙、磷浓度均正常。BMI-Z分值≤-1与Vit D缺乏或不足相关，而VDR基因多态性、性别及居住地并非危险因素。结论地中海贫血患儿Vit D缺乏或不足发生率高，且与贫血严重程度以及营养状态相关。

关键词

地中海贫血 / 维生素D / 危险因素

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李仕勇，陈一菁，邹金林，班克创，陈剑锋. 地中海贫血患儿维生素D水平及影响因素分析[J]. 中国儿童保健杂志. 2015, 23(2): 119-122 https://doi.org/10.11852/zgetbjzz2015-23-02-03

LI Shi-yong,CHEN Yi-jing,ZOU Jin-lin,BAN Ke-chuang,CHEN Jian-feng.. Analysis of status and possible risk factors of vitamin D deficiency in children with thalassemia.[J]. Chinese Journal of Child Health Care. 2015, 23(2): 119-122 https://doi.org/10.11852/zgetbjzz2015-23-02-03

中图分类号： R153.2

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