目的 了解早期综合干预对早产儿早期发育商的影响,为开展系统的早产儿早期综合干预提供临床依据。方法 以家长积极参与早产儿早期干预的早产儿为干预组,家长因各种原因不愿参加干预的早产儿为对照组。对干预组的早产儿进行定期随访并实施早期干预,每月采用鲍秀兰教授简化的20项神经运动检查进行评估,于纠正6月龄时采用首都儿科研究所编制的《0~6岁小儿神经心理发育量表》进行发育商测试。结果 纠正6月龄时20项神经运动评估异常项目≥3项的比例,干预组为8.6%,未干预组为30%,两组差异有统计学意义(χ²=5.35,P＜0.05);异常项目≥1项的比例,干预组为20%,未干预组为50%,两组差异有统计学意义(χ²=7.29,P＜0.05);纠正6月龄时《0~6岁小儿神经心理发育量表》评估,结果显示,干预组婴儿除大运动能区外,其余4个能区的DQ值均高于未干预组,差异有统计学意义(精细动作t=4.81,适应能力t=3.42,语言t=5.33,社交行为t=3.45,P均＜0.01)。结论 有效的早期综合干预可改善早产儿神经运动发育,对早产儿早期发育商有积极的影响。

Objective To understand the effects of early comprehensive intervention on early developmental quotient of premature infants and provide clinical basis for early comprehensive intervention on premature infants. Methods Participants falled into two groups.Treatment group included parents participating actively in early intervention,and control group included parents who didn't participate for various reasons.By regular follow-up and early intervention,《0~6 year-old Children's Neuropsychological Development Scale》 compiled by the capital institute of pediatrics was used to test development quotient of 6 months premature infants. Results Abnormal proportion of 20 items of neuromotor assessment ≥3 was corrected,intervention group was 8.6%,control group was 30%,and there was a statistical difference between the two groups (χ²=5.35,P<0.05);Project of one or more abnormal proportion was 20% in intervention group and 50% in control group,the difference between the two groups was statistically significant (χ²=7.29,P<0.05);When correcting 6 months,assessment,results showed that except for gross movement,intervention group infants' DQ values were higher than no intervention group in the rest four zones,with a statistical significance of the difference (fine movement t=4.81,adaptive capacity t=3.42,language t=5.33,social behavior t=3.45,all P<0.01). Conclusion Effective early comprehensive intervention can improve neuro motor development of premature,and it has positive effect on premature infants' early developmental quotient.