目的 研究可乐定缓释片单一治疗小儿抽动症的有效性及不良反应。方法 对本次研究的110例抽动症患儿进行随机分组,分成治疗组和对照组,各为55例;治疗组:单独口服可乐定缓释片。对照组:口服氟哌啶醇和同等剂量安坦。治疗时间为12周,比较和分析两组患儿的疗效及不良反应。结果 研究组临床疗效与对照组差异无统计学意义(χ²=0.267,P＞0.05),但其安全性明显高于对照组。结论 可乐定缓释片能有效改善儿童抽动症的运动,发声抽动和综合损伤,不良反应与氟哌啶醇合用等量安坦相比明显少而轻。

Objective To explore the effect and adverse reaction of using clonidine sustained release tablets in the treatment of tourette syndrome (TS). Methods Total 110 cases of children with TS were randomly selected into treatment group and control group,55 cases in each group.Treatment group took only clonidine sustained release tablets.Control Group took haloperidol add the same dose of artane.The efficacy and adverse reactions of the two groups of children were compared and analyzed within 12 weeks. Results There was no significant difference between the treatment group and the control group in clinical curative (χ²=0.267P>0.05),but the safety of the former group was significantly higher than the latter. Conclusion Clonidine sustained release tablets can effectively improve the movement of children with tourette syndrome,vocal tics and combined injury.Its adverse reactions are obviously less and milder compared with haloperidol add the same dose of artane.