目的 研究新生儿胆红素性脑损伤患儿血清神经元特异性烯醇化酶(serum neuron-specific enolase, s-NSE)含量与血清胆红素、白蛋白及B/A值的关系。方法 采用ELISA法测定高胆红素血症新生儿血清s-NSE含量, 全自动生化分析仪测定其血清间接胆红素数值(UCB)、白蛋白数值(A), 计算间接胆红素与白蛋白的比值(B/A);将62例s-NSE含量增高患儿分成两组:s-NSE值轻度增高组和s-NSE值重度增高组, 分析两组血清指标的差异, 以及s-NSE值与各指标的相关性。结果 两组间UCB值差异有统计学意义(P<0.05), A值无统计学意义(P>0.05), B/A值差异有统计学意义(P<0.001); s-NSE值与B/A值呈高度正相关性(r=0.687, P<0.001)。结论 B/A比值能较好的反应胆红素性脑损害, 临床可通过对B/A值的监测, 指导高胆红素血症患儿的合理干预。

Objective To explore relationships of serum neuron-specific enolase (NSE) and serum bilirubin, albumin and B/A values, in neonates suffering from hyperbilirubin-induced brain injury. Methods Serum NSE contents (s-NSE)of hyperbilirubinemia infants were determined by ELISA.Serum indirect bilirubin values (s-UCB) and albumin values (A) were measured by full-automatic biochemical analyzerm, and indirect bilirubin and albumin ratio (B/A) was calculated.The 62 cases with increased s-NSE concentrations were devided into two groups:mildly increased s-NSE values group and highly increased s-NSE values group, then differences of serum indicators from the two groups, and correlations of s-NSE values and the serum indicators were analyzed. Results There were significant difference in s-UCB value (P<0.05), no significant difference in A values (P>0.05), and very significant difference in B/A value (P<0.001) between two groups.There was a good positive correlation between s-NSE value and the B/A value (r=0.687, P<0.001). Conclusions B/A ratio could be a good mark to hyperbilirubin-induced brain injury.Through monitoring B/A ratio, neonates with hyperbilirubinemia may reasonably be intervened.