目的 研究颅内出血足月新生儿血清中白介素-6(IL-6)、及肿瘤坏死因子-α(TNF-α)的变化及其临床意义。方法 用ELISA法测定50例颅内出血足月新生儿和26例健康新生儿的血清 IL-6、TNF-α水平的变化。结果 颅内出血足月新生儿血清IL-6、TNF-α水平明显升高, 与对照组比较, 差异有统计学意义(P＜0.05);IL-6、TNF-α水平在不同出血量组之间IL-6、TNF-α比较, 差异有统计学意义(P＜0.05);IL-6、TNF-α水平在不同出血量组部位之间IL-6、TNF-α比较, 差异无统计学意义(P＞0.05)。结论 颅内出血足月新生儿血清IL-6、TNF-α水平明显增高, 可作为判断病情和评估预后的指标。
Abstract
Objective To explore the changes and clinical significance of serum levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in newborns with intracranial hemorrhage. Method The levels of IL-6 and TNF-α blood plasma in 50 neonates with intracranial haemorrhage (case group) and 26 healthy neonates (control group) were detected by ELISA. Results The levels of IL-6 and TNF-α in case group were significantly higher than those in control group (P<0.05);There were significant differences in levels of IL-6 and TNF-α between different amounts of bleeding group (P<0.05). Conclusions Serum levels of IL-6 and TNF-α creases obviously in newborns with intracranial hemorrhage, suggesting that they might be used as reference index in assessing pathogenetic condition and appraising prognosis.
关键词
颅内出血 /
白介素-6 /
肿瘤坏死因子-α /
新生儿
Key words
intracranial haemorrhage /
interleukin-6 /
tumor necrosis factor-α /
neonates
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参考文献
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