目的 通过扩散张量技术观察学龄期高功能孤独症儿童脑白质微结构的异常,探讨其可能的神经发育异常证据。方法 对14例学龄期高功能孤独症男童(孤独症组:acdism spectrum disorders,ASDs组)及7名年龄、智力水平及利手均匹配的正常发育男童(正常对照组:TD组)行扩散张量成像观察,运用体素水平分析方法将两组的各向异性分数(fractional anisotropy,FA)及平均扩散水平(mean diffusivity,MD)进行对比分析。结果 相对于TD组,ASDs组在左侧颞叶、左侧额叶、左侧枕叶以及海马、丘脑等皮质下核团的FA值升高,在左侧距状裂、双侧梭状回、右侧颞叶、右侧额叶、右侧枕叶以及左侧海马旁回、后扣带回、左侧舌回的MD值均降低。结论 学龄期高功能孤独症儿童脑白质多个区域存在微结构的异常。
Abstract
Objective To examine the abnormal white matter microstructure of acdism spectrum disorders (ASDs) children of school age via Diffusion Tensor Imaging,so as to investigate the possible evidence of dysplasia of neurodevelopment. Methods 14 ASDs boys of school age and 7 age,IQ and handedness matched typically developing controls were examined by diffusion tensor imaging (DTI),the fractional anisotropy (FA) and mean diffusivity (MD) values were compared between two groups through voxel-based analysis. Results Compare to TD group,the FA value was increased in the left temporal gyrus,left frontal gyrus,left occipital gyrus,hippocampus and thalamus,and the MD value was decreased in the left calcarine fissure,bilateral fusiform gyrus,right temporal gyrus,right frontal gyrus,right occipital gyrus,left parahippocampus gyrus,posterior cingulate cortex and left lingual gyrus in ASDs group. Conclusion Abnormal white matter microstructure widely spread over the brain of high-functional autism of school age.
关键词
高功能孤独症 /
扩散张量成像 /
体素水平分析
Key words
high-functional autism /
diffusion tensor imaging /
voxel-based analyze
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参考文献
[1] Billeci L,Calderoni S,Tosetti M,et al.White matter connectivity in children with autism spectrum disorders:a tract-based spatial statistics study[J].BMC Neurology,2012,12(148):1-16.
[2] Nagae LM,Zarnow DM,Blaskey L,et al.Elevated mean diffusivity in the left hemisphere superior longitudinal fasciculus in autism spectrum disorders increases with more profound language impairment[J].American Journal of Neuroradiology,2012,33(9):1720-1725.
[3] Lewis JD,Theilmann RJ,Fonov V,et al.Callosal fiber length and interhemispheric connectivity in adults with autism:Brain overgrowth and underconnectivity[J].Human Brain Mapping,2013,34(7):1685-1695.
[4] Poustka L,Jennen-Steinmetz C,Henze R,et al.Fronto-temporal disconnectivity and symptom severity in children with autism spectrum disorder[J].World Journal of Biological Psychiatry,2012,13(4):269-280.
[5] 黄文盛,周红.磁共振弥散张量成像技术在脑白质病变与认知功能障碍关系研究中的作用[J].东南大学学报:医学版,2013,(04):522-525.
[6] 花蒨蒨,张雪林.磁共振扩散张量成像在中枢神经系统的应用研究进展[J].中华神经医学杂志,2007,12:1286-1289.
[7] Mills BD,Lai J,Brown TT,et al.White matter microstructure correlates of narrative production in typically developing children and children with high functioning autism[J].Neuropsychologia,2013,51(10):1933-1941.
[8] 温金峰,潘集阳.儿童孤独症脑白质纤维束弥散张量成像研究[Z].中国北京:20132:106-107.
[9] Koldewyn K,Yendiki A,Weigelt S,et al.Differences in the right inferior longitudinal fasciculus but no general disruption of white matter tracts in children with autism spectrum disorder[J].Proc Natl Acad Sci USA,2014,111(5):1981-1986.
[10] Li H,Xue Z,Ellmore TM,et al.Network-based analysis reveals stronger local diffusion-based connectivity and different correlations with oral language skills in brains of children with high functioning autism spectrum disorders[J].Hum Brain Mapp,2014,35(2):396-413.
[11] Ben BD,Kronfeld-Duenias V,Zachor DA,et al.Accelerated maturation of white matter in young children with autism:a high b value DWI study[J].Neuroimage,2007,37(1):40-47.
[12] Alexander AL,Lee JE,Lazar M,et al.Diffusion tensor imaging of the corpus callosum in Autism[J].Neuroimage,2007,34(1):61-73.
[13] Hong S,Ke X,Tang T,et al.Detecting abnormalities of corpus callosum connectivity in autism using magnetic resonance imaging and diffusion tensor tractography[J].Psychiatry Res,2011,194(3):333-339.
[14] Conturo TE,Williams DL,Smith CD,et al.Neuronal fiber pathway abnormalities in autism:an initial MRI diffusion tensor tracking study of hippocampo-fusiform and amygdalo-fusiform pathways[J].J Int Neuropsychol Soc,2008,14(6):933-946.
[15] Kleinhans NM,Pauley G,Richards T,et al.Age-related abnormalities in white matter microstructure in autism spectrum disorders[J].Brain Res,2012,1479:1-16.
[16] Cheng Y,Chou KH,Chen IY,et al.Atypical development of white matter microstructure in adolescents with autism spectrum disorders[J].Neuroimage,2010,50(3):873-882.
[17] Dawson G,Munson J,Webb SJ,et al.Rate of head growth decelerates and symptoms worsen in the second year of life in autism[J].Biol Psychiatry,2007,61(4):458-464.
[18] Dennis EL,Thompson PM.Mapping connectivity in the developing brain[J].Int J Dev Neurosci,2013,31(7):525-542.
[19] Sundaram SK,Kumar A,Makki MI,et al.Diffusion tensor imaging of frontal lobe in autism spectrum disorder[J].Cereb Cortex,2008,18(11):2659-2665.
[20] Courchesne E,Pierce K,Schumann CM,et al.Mapping early brain development in autism[J].Neuron,2007,56(2):399-413.
基金
国家自然科学基金(81172687);国家自然科学基金(31100738)
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