Abstract

摘要： 新生儿缺氧缺血性脑损伤(hypoxic-ischemic brain damage,HIBD)的发病率呈逐年上升趋势,严重者可造成新生儿神经系统永久性损伤,尽管已采用亚低温、高压氧、神经营养药物等治疗措施,但这些治疗手段对重度损伤的神经细胞疗效甚差。而神经干细胞具有自我更新和多向分化的潜能,不管是外源性移植还是诱导自身神经干细胞增殖分化对神经损伤均有修复作用,这为临床治疗神经系统退行性疾病带来了新的生机,同时也为治疗新生儿HIBD带来了新的希望,但远期疗效仍然难以评估。现就神经干细胞(neural stem cell,NSCs)在体内的变化特点、内源性和外源性NSCs对HIBD的治疗效应以及NSCs在HIBD治疗中存在问题做一综述,以加深人们对NSCs治疗HIBD的认识。

关键词: 缺氧缺血性脑损伤, 神经干细胞, 新生儿

CLC Number:

R722.1

王钰综述, 尹晓娟审校. 神经干细胞在治疗缺氧缺血性脑损伤中的研究进展[J]. 中国儿童保健杂志, 2012, 20(9): 826-828.

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神经干细胞在治疗缺氧缺血性脑损伤中的研究进展

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