Abstract

摘要： 肺表面活性物质是存在于肺泡气液交界面上的一种复杂脂蛋白复合物,不仅具有降低肺泡表面张力、避免呼气末肺泡塌陷的作用,而且具有先天性免疫的作用,可以对抗病原体入侵。其先天性或继发性的肺表面活性物质质与量的任一改变是新生儿呼吸系统发病的潜在病因,甚至引起新生儿呼吸窘迫综合征、支气管肺发育不良、重症肺炎等致死性疾病,严重影响了新生儿的患病率和生存率,远期影响了儿童的生命质量,现就肺表面活性物质的生物学特性、代谢及其代谢异常与疾病发病的关系等方面做一综述,以期加深人们对肺表面活性物质的新认识,为临床诊治拓宽视野。

关键词: 新生儿, 肺表面活性物质, 代谢, 疾病

CLC Number:

R722.1

谢露综述, 尹晓娟审校. 新生儿肺表面活性物质研究新进展[J]. 中国儿童保健杂志, 2012, 20(3): 235-237.

References

[1] Paul ON,Allen M T,De-Ann MP.An overview of pulmonary surfactant in the neonate:genetics,metabolism,and the role of surfactant in health and disease[J].Mol Genet Met,2009,97(2):95-101.
[2] Wert SE,Whitsett JA,Nogee LM.Genetic disorders of surfactant dysfunction[J].Pediatr Dev Pathol,2009,12(4):253-274.
[3] Haczku A.Protective role of the lung collectins surfactant protein A and surfactant protein D in airway inflammation[J].J Allergy Clin Immunol,2008,122(5):861-879.
[4] Pérez-Gil J.Structure of pulmonary surfactant membranes and films:the role of proteins and lipid-protein interactions[J].Biochim Biophys Acta,2008,1778(7-8):1676-1695.
[5] Guttentag S.Posttranslational regulation of surfactant protein B expression[J].Semin Perinatol,2008,32(5):367-370.
[6] Glasser SW,Senft AP,Whitsett JA,et al.Macrophage dysfunction and susceptibility to pulmonary Pseudomonas aeruginosa infection in surfactant protein C-deficient mice[J].J Immunol,2008,181(1):621-628.
[7] Glasser SW,Witt TL,Senft AP,et al.Surfactant protein C-deficient mice are susceptible to respiratory syncytial virus infection[J].Am J Physiol Lung Cell Mol Physiol,2009,297(1):64-72.
[8] Chroneos ZC,Sever-Chroneos Z,Shepherd VL. Pulmonary surfactant: an immunological perspective[J].Cell Physiol Biochem,2010,25(1):13-26.
[9] 尹晓娟,罗分平,李爱华,等.20例汉族新生儿呼吸窘迫综合征肺表面活性物质蛋白B遗传缺陷的研究[J].中华儿科杂志,2008,46(1):9-12.
[10] Schuerman FA,Griese M,Gille JP,et al.Surfactant protein B deficiency caused by a novel mutation involving multiple exons of the SP-B gene[J].Eur J Med Res,2008,13(6):281-286.
[11] 尹晓娟,谢露,池婧涵,等.SP-B遗传缺陷导致足月儿新生儿呼吸窘迫综合征三例[J].中国新生儿科杂志,2011,26(4):268-268.
[12] Faro A,Hamvas A.Lung transplantation for inherited disorders of surfactant metabolism[J].Neo Reviews,2008,9(10):468-476.
[13] Mary KD,Peggy O,Pallavi PP,et al.The influence of genetic variation in surfactant protein B on severe lung injury in African American children[J].Crit Care Med,2011,39(5):1138-1144.
[14] Deutsch GH,Young LR,Deterding RR,et al.Diffuse lung disease in young children:application of a novel classification scheme[J].Am J Respir Crit Care Med,2007,176(11):1120-1128.
[15] Matsumura Y,Ban N,Inagaki N.Aberrant catalytic cycle and impaired lipid transport into intracellular vesicles in ABCA3 mutants associated with nonfatal pediatric interstitial lung diseas[J].Am J Physiol Lung Cell Mol Physiol,2008,295(4):698-707.

新生儿肺表面活性物质研究新进展

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

[1]	CUI Pengyuan, LI Guiping. Causal relationship between neonatalhy perbilirubinemia and tic disorder by Mendelian randomization [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1116-1121.
[2]	. [J]. Chinese Journal of Child Health Care, 2024, 32(9): 929-933.
[3]	WEI Ping, WEI Jishan, HUANG Xuhua, ZHANG Yuxing, LIU Xianghong, HE Zhongbiao, MO Jingyuan, HUANG Zengshuai, YU Qun. Application of cardiac auscultation, pulse oximetry combine with oxygen inhalation in screening neonatal congenital heart disease in Guangxi Province [J]. Chinese Journal of Child Health Care, 2024, 32(9): 1034-1039.
[4]	HUANG Wanyi, ZHANG Youxiang, OU Qiaoqun, LIU Yuanchun, GUO Jiayu. Effects of gestational diabetes mellitus on brain development and miRNAs expression profile in neonatal mice [J]. Chinese Journal of Child Health Care, 2024, 32(2): 154-158.
[5]	LU Anfeng, HUANG Peilu, BI Lei, HUANG Guosheng, HUANG Haiyan. Physical and neuropsychological development of the offspring born to mother with gestational diabetes mellitus at 2 years old [J]. Chinese Journal of Child Health Care, 2024, 32(2): 208-211.
[6]	WEI Jufang, CHEN Jijian. Trends and influencing factors of low birth weight of newborns in Xixiangtang District, Nanning City from 2015 to 2021 [J]. Chinese Journal of Child Health Care, 2023, 31(7): 785-789.
[7]	. [J]. Chinese Journal of Child Health Care, 2023, 31(2): 225-228.
[8]	CHEN Yu-xia, LIU Hua-yan, FAN Qian-qian. Changes of neuron specific enolase, transcutaneous hour bilirubin, total bilirubin/albumin levels in full-term infants with hyperbilirubinemia and their correlation with long-term neurodevelopment [J]. Chinese Journal of Child Health Care, 2023, 31(1): 86-90.
[9]	ZHANG Du-fei, ZHANG Xiang-yun. Epidemiological survey on neonatal congenital heart disease in Hainan Province in 2020 [J]. Chinese Journal of Child Health Care, 2023, 31(1): 91-95.
[10]	WANG Hui-ping, WANG Li, GAO Qiong, BAI Bo-liang, MA Ying-jun. Physical and neurological development of necrotizing enterocolitis in very low birth weight infants [J]. Chinese Journal of Child Health Care, 2023, 31(1): 96-100.
[11]	LIANG Li-yu, ZHU Hui. Prognosis of neonates with mild hyperthyrotropinemia [J]. Chinese Journal of Child Health Care, 2022, 30(12): 1409-1413.
[12]	LIANG Sui-xin, TI Yun-xing, HUANG Jun-rong, LI Xiu-hong, ZHOU Wen-jia. Protective effect and mechanism of delayed mild hypothermia on white matter injury inoxygen-glucose deprivation and restoration newborn rats [J]. Chinese Journal of Child Health Care, 2022, 30(10): 1083-1087.
[13]	LIU Jian-hong, HUANG Fang. Association of serum NFP and Nrf2 levels with early brain injury in neonatal asphyxia [J]. Chinese Journal of Child Health Care, 2022, 30(7): 787-791.
[14]	DONG Li-ping, ZHANG Zhen, CUI Yan-guo, LI Qing-bo. Application of screening indices for methylmalonic acidemia in Zibo city [J]. Chinese Journal of Child Health Care, 2022, 30(7): 792-795.
[15]	ZHOU Li-xia, CAI Dong, CHEN You-ping. Effect of melatonin regulating Akt/mTOR signal pathway on intestinal barrier function in neonatal rats with necrotizing enterocolitis [J]. Chinese Journal of Child Health Care, 2022, 30(6): 622-626.