Research progress in the relationship between rapid catch-up growth and childhood obesity in small for gestational age infants

doi:10.11852/zgetbjzz2022-0757

Abstract

Abstract: Because of the lifting of intrauterine growth restriction and the altered nutritional environment after birth, most small for gestational age (SGA) would have catch-up growth.Catch-up growth can promote the physical development and improve the quality of survival of SGA.Recently, there is much evidence that rapid catch-up growth is associated with childhood obesity, while breastfeeding can reduce the incidence of obesity.This article reviews the progress in the relationship between rapid catch-up growth of SGA and childhood obesity, and discusses possible mechanisms.

Key words: small for gestational age infants, catch-up growth, obesity, breastfeeding

摘要： 由于宫内生长受限的解除以及出生后的营养环境改变,大部分小于胎龄(SGA)儿都会出现追赶生长。追赶生长可以促进SGA儿的体格发育,提高生存质量。近年来许多研究表明SGA儿过快追赶生长与儿童期肥胖密切相关,母乳喂养可降低肥胖的发生率。本文就SGA儿过快追赶生长与儿童期肥胖关系、可能机制的研究进展做一综述。

关键词: 小于胎龄儿, 追赶生长, 肥胖, 母乳喂养

CLC Number:

R179

LI Mingzhu, WANG Jing, XIE Duoshuang. Research progress in the relationship between rapid catch-up growth and childhood obesity in small for gestational age infants[J]. Chinese Journal of Child Health Care, 2023, 31(7): 751-755.

李茗竹, 王静, 谢多双. 小于胎龄儿过快追赶生长与儿童期肥胖关系的研究[J]. 中国儿童保健杂志, 2023, 31(7): 751-755.

References

[1] Lee AC, Katz J, Blencowe H, et al.National and regional estimates of term and preterm babies born small for gestational age in 138 low-income and middle-income countries in 2010[J].Lancet Glob Health, 2013, 1(1): e26-36.
[2] 王庆红, 杨于嘉, 魏克伦, 等.我国小于胎龄儿现状分析[J].中国实用儿科杂志, 2009, 24(3): 177-180.
Wang QH,Yang YJ,Wei KL.Current situation Investigation and analysis of SGA in China[J].Chinese J Practical Pediatrics, 2009, 24(3): 177-180.(in Chinese)
[3] 张伟, 茹彤, 胡娅莉.正确认识小于胎龄儿[J].中华围产医学杂志, 2014, 17(7): 495-498.
Zhang W, Ru T, Hu LY.A correct understanding of SGA[J].Chinese JPerinatal Medicine, 2014, 17(7): 495-498.(in Chinese)
[4] Chen Y, Wang Y, Chen Z, et al.The effects of rapid growth on body mass index and percent body fat: A Meta-analysis[J].Clin Nutr, 2020, 39(11): 3262-3272.
[5] 宋泽宇,李秀红.早产儿早期追赶生长对后期发育影响的研究进展[J].中国儿童保健杂志,2017,25(3): 265-267.
Song ZY, Li XH.Influence of early catch-up growth on late physiological and neuropsychological development in preterm neonates:A review of recent study[J].Chin J Child Health Care, 2017, 25(3): 265-267.(in Chinese)
[6] 陈祝秀, 李晓南.小于胎龄儿追赶性生长的研究进展[J].中国儿童保健杂志, 2021, 29(6): 619-622,631.
Chen ZX,Li XN.Research progress on catch-up growth of small for gestational age[J].Chin J Child Health Care,2021,29(6):619-622,631.(in Chinese)
[7] 王丹华,刘喜红.早产、低出生体重儿出院后喂养建议[J].中华儿科杂志, 2016, 54(1): 6-12.
Wang DH, Liu XH.Recommendations for feeding preterm, low birth weight infants after discharge from hospital[J].Chin J Pediatr, 2016, 54(1): 6-12.(in Chinese)
[8] 张继永, 林燕燕, 白海涛.小于胎龄儿0～24月龄体格生长状况分析[J].中国全科医学, 2020, 23(32): 4069-4073,4079.
Zhang JY, Lin YY, Bai HT.Analysis of physical growth of small for gestational age infants at 0-24 months[J].Chinese General Practice, 2020, 23(32): 4069-4073,4079.(in Chinese)
[9] Argente J, Mehls O, Barrios V.Growth and body composition in very young SGA children[J].Pediatr Nephrol, 2010, 25(4): 679-685.
[10] 唐孟言, 刘孝美, 彭文涛, 等.早产儿12月龄体重追赶生长现状及影响因素分析[J].中华护理杂志, 2020, 55(8): 1159-1163.
Tang MY, Liu XM, Peng WT, et al.The current situation of premature infants^′weight catch-up growth at 12 months and its influencing factors[J].Chin J Nurs, 2020, 55(8): 1159-1163.(in Chinese)
[11] 刘美燕.小于胎龄儿喂养建议新进展[J].国际儿科学杂志, 2020, 47(6): 394-397.
Liu MY.Progress in feeding recommendations for small for gestational age infants[J].International Journal of Pediatrics, 2020, 47(6): 394-397.(in Chinese)
[12] 王思弦, 梁琨.早产儿追赶性生长与代谢综合征的关联性研究进展[J].中国儿童保健杂志, 2019, 27(7): 745-748.
Wang SX, Liang K.Recent advances in catch-up growth and metabolic syndrome of premature infants[J].Chin J Child Health Care, 2019, 27(7): 745-748.(in Chinese)
[13] Horta BL, Loret De Mola C, Victora CG.Long-term consequences of breastfeeding on cholesterol, obesity, systolic blood pressure and type 2 diabetes: a systematic review and meta-analysis[J].Acta Paediatr, 2015, 104(467): 30-37.
[14] 徐冬梅, 冯彩英, 杜红梅, 等.母乳喂养与中国0～6岁儿童肥胖发生风险关系的Meta分析[J].郑州大学学报(医学版), 2017, 52(1): 71-74.
Xu DM, Feng CY, Du HM, et al.Association between breastfeeding and risk of obesity in 0-6 years old Chinese children:a meta-analysis[J].Journal of Zhengzhou University(Medical Sciences), 2017, 52(1): 71-74.(in Chinese)
[15] 滕晓雨, 杨召川, 衣明纪.母乳喂养婴儿肥胖的危险因素及预后研究进展[J].中国儿童保健杂志,2018,26(2): 171-173,180.
Teng XY, Yang ZC, Yi MJ.Risk factors and prognosis of obesity in breast-fed infants[J].Chin J Child Health Care, 2018, 26(2): 171-173,180.(in Chinese)
[16] Goedegebuure WJ, Van Der Steen M, Smeets CCJ, et al.SGA-born adults with postnatal catch-up have a persistently unfavourable metabolic health profile and increased adiposity at age 32 years[J].Eur J Endocrinol, 2022, 187(1): 15-26.
[17] 刘利蕊, 赵宏伟, 王燕, 等.早产儿学龄前期肥胖的相关危险因素分析[J].现代预防医学, 2017, 44(12): 2168-2170,2201.
Liu LR, Zhao HW, Wang Y, et al.The risk factors of obesity for preterm infants at preschool age[J].Modern Preventive Medicine, 2017, 44(12): 2168-2170,2201.(in Chinese)
[18] Al-Theyab NA, Donovan TJ, Eiby YA, et al.Fat trajectory after birth in very preterm infants mimics healthy term infants[J].Pediatr Obes, 2019, 14(3): e12472.
[19] 周玉润, 陈婕, 孙建乐,等.低出生体重儿追赶性生长跨度与儿童期超重肥胖的相关性研究[J].中国儿童保健杂志, 2018, 26(3): 236-238,250.
Zhou YR, Chen J, Sun JL, et al.Correlation study on catch-up growth span in low birth weight infants and overweight or obesity in childhood[J].Chin J Child Health Care, 2018, 26(3): 236-238,250.(in Chinese)
[20] 吴丹, 汪秀莲, 霍言言,等.足月小于胎龄儿婴儿期增长速率与学龄期肥胖风险的纵向队列研究[J].中国儿童保健杂志, 2019, 27(11): 1163-1166.
Wu D, Wang XL, Huo YY, et al.Longitudinal cohort study on the correlation between growth rate and obesity risk of small for gestational age infants[J].Chin J Child Health Care, 2019, 27(11): 1163-1166.(in Chinese)
[21] Myrie SB, Mcknight LL, King JC, et al.Intrauterine growth-restricted Yucatan miniature pigs experience early catch-up growth, leading to greater adiposity and impaired lipid metabolism as young adults[J].Appl Physiol Nutr Metab, 2017, 42(12): 1322-1329.
[22] Harrington TA, Thomas EL, Frost G, et al.Distribution of adipose tissue in the newborn[J].Pediatr Res, 2004, 55(3): 437-441.
[23] Soto N, Bazaes RA, Peña V, et al.Insulin sensitivity and secretion are related to catch-up growth in small-for-gestational-age infants at age 1 year: Results from a prospective cohort[J].J Clin Endocrinol Metab, 2003, 88(8): 3645-3650.
[24] Embleton ND, Korada M, Wood CL, et al.Catch-up growth and metabolic outcomes in adolescents born preterm[J].Arch Dis Child, 2016, 101(11): 1026-1031.
[25] Ekelund U, Ong KK, Linné Y, et al.Association of weight gain in infancy and early childhood with metabolic risk in young adults[J].J Clin Endocrinol Metab, 2007, 92(1): 98-103.
[26] Claris O, Beltrand J, Levy-Marchal C.Consequences of intrauterine growth and early neonatal catch-up growth[J].Semin Perinatol, 2010, 34(3): 207-210.
[27] Hales CN, Barker DJ.Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis.1992[J].Int J Epidemiol, 2013, 42(5): 1215-1222.
[28] Lizarraga-Mollinedo E, Carreras-Badosa G, Xargay-Torrent S, et al.Catch-up growth in juvenile rats, fat expansion, and dysregulation of visceral adipose tissue[J].Pediatr Res, 2022, 91(1): 107-115.
[29] Yaribeygi H, Farrokhi FR, Butler AE, et al.Insulin resistance: Review of the underlying molecular mechanisms[J].J Cell Physiol, 2019, 234(6): 8152-8161.
[30] Liu C, Wu B, Lin N, et al.Insulin resistance and its association with catch-up growth in Chinese children born small for gestational age[J].Obesity (Silver Spring), 2017, 25(1): 172-177.
[31] 王成斌, 郑锐丹, 高金枝, 等.胰岛素受体底物在生长追赶宫内发育迟缓新生大鼠脂肪细胞中的表达[J].临床儿科杂志, 2014, 32(12): 1162-1167.
Wang CB, Zheng RD, Gao JZ, et al.The expressions of insulin receptor substrate in adipocytes during catch-up growth in neonatal rats with intrauterine growth retardation[J].Journal of Clinical Pediatrics, 2014, 32(12): 1162-1167.(in Chinese)
[32] Yadav A, Kataria MA, Saini V, et al.Role of leptin and adiponectin in insulin resistance[J].Clin Chim Acta, 2013, 417: 80-84.
[33] 麦天恩, 陈志凤, 黄琳淇,等.宫内发育迟缓婴儿胰岛素样生长因子-1与瘦素水平变化及其意义[J].广东医学, 2011, 32(3): 338-340.
Mai TE, Chen ZF, Huang LQ, et al.Significance of changes in the levels of insulin grow factor-1 and leptin in neonated with intrauterine growth retardation[J].Guangdong Medical Journal, 2011, 32(3): 338-340.(in Chinese)
[34] Saito M, Nishimura K, Nozue H, et al.Changes in serum adiponectin levels from birth to term-equivalent age are associated with postnatal weight gain in preterm infants[J].Neonatology, 2011, 100(1): 93-98.
[35] Cianfarani S, Martinez C, Maiorana A, et al.Adiponectin levels are reduced in children born small for gestational age and are inversely related to postnatal catch-up growth[J].J Clin Endocrinol Metab, 2004, 89(3): 1346-1351.
[36] 唐本玉, 陈丹纯, 郭蕾, 等.宫内发育迟缓雌性仔鼠早期营养对生长追赶的影响[J].中山大学学报(医学版), 2019, 40(4): 532-539.
Tang BY, Chen DC, Guo L, et al.Effects of early life nutritional status on weight catch-up growth,puberty initiation and obesity in female rats with intrauterine growth retardation[J].Journal of Sun Yat-sen University(Medical Sciences), 2019, 40(4): 532-539.(in Chinese)
[37] Sebastiani G, García-Beltran C, Pie S, et al.The sequence of prenatal growth restraint and postnatal catch-up growth:Normal heart but thicker intima-media and more pre-peritoneal fat in late infancy[J].Pediatr Obes, 2019, 14(3): e12476.
[38] 祝素萍.大鼠追赶生长早期骨骼肌脂质代谢异常及其机制的初步探讨[D].武汉:华中科技大学, 2009.
Zhu SP.A preliminary study on abnormal skeletal lipid metabolism in early catching-up-growth in adult rats and related mechanisms[D].Wuhan:Huazhong University of Science and Technology, 2009.(in Chinese)
[39] Hu X, Chen LL, Zheng J, et al.Increases in systemic and local stress: a probable mechanism of visceral fat accumulation and insulin resistance in adult catch-up growth rats?[J].Exp Biol Med (Maywood), 2013, 238(1): 57-65.
[40] Crescenzo R, Samec S, Antic V, et al.A role for suppressed thermogenesis favoring catch-up fat in the pathophysiology of catch-up growth[J].Diabetes, 2003, 52(5): 1090-1097.
[41] Diaz M, Garde E, Lopez-Bermejo A, et al.Differential DNA methylation profile in infants born small-for-gestational-age: Association with markers of adiposity and insulin resistance from birth to age 24 months[J].BMJ Open Diabetes Res Care, 2020, 8(1): e001402.