doi:10.11852/zgetbjzz2016-24-11-16

Abstract

摘要： 新生儿B族溶血链球菌属β溶血链球菌(GBS)。由于对有危险因素的孕妇预防使用抗生素,新生儿GBS感染的发生率有所下降,但GBS耐药率有上升趋势。GBS耐药的主要血清型为血清型Ⅲ、Ⅰa、Ⅰb、Ⅱ、Ⅴ型,目前发现的大环内酯类抗生素耐药基因有ermA、ermB、mefA/E和linB等。疫苗的研究主要建立在血清型、ST-17基因的基础上,其中血清型主要集中于Ⅲ型及Ⅴ型。

关键词: 新生儿, 无乳链球菌, 耐药性, 耐药基因, 疫苗

CLC Number:

R179

苏锦珍,丁璐,吴本清. 新生儿B族溶血链球菌的耐药性及疫苗研究进展[J]. 中国儿童保健杂志, 2016, 24(11): 1174-1176.

[1] Wolny-Koladka K.Valuationof ITS-PCR and PCR MP techniques for Streptococcus agalactiae genetic differentiation[J].Med Dosw Mikrobiol,2014,66(3-4):149-160.
[2] Crespo-Ortiz Mdel P,Castaeda-Ramirez CR,Recalde-Bolaos M,et al.Emerging trends in invasive and noninvasive isolates of Streptococcus agalactiae in a Latin American hospital:a 17-year study[J].BMC Infect Dis,2014,3(8):1471-2334.
[3] Chang B,Wada A,Hosoya M,et al.Characteristics of group B streptococcus isolated from infants with invasive infections:A population-based study in Japan[J].Jpn J Infect Dis,2014,67(5):356-360.
[4] Florindo,Damiao V,Silvestre I,et al.Epidemiological surveillance of colonising goup B Steptococcus epidemiology in the Lisbon and Tagus Valley regions,Portugal(2015-2012):emergence of a new epidemic type IV/clonal complex 17 clone[J].Euro Surveill,2014,19(23):20825.
[5] Goudarzi G,Ghafarzadeh M,Shakib P,et al.Culture and real-time PCR based maternal screening and antibiotic susceptibility for group B Streptococcus:An Iranian experience[J].Glob J Health Sci,2015,7(6):45075.
[6] Soares GC,Alviano DS,da Silva Santos G,et al.Prevalence of group B streptococcus serotypes Ⅲ and Ⅴ in pregnant women of Rio de Janeiro,Brazil[J].Braz J Microbiol,2014,44(3):869-872.
[7] Stafford IA,Stewart RD,Sheffield JS,et al.Efficacy of maternal and neonatal chemoprophylaxis for early-onset group B streptococcal disease[J].Obstet Gynecol,2012,120(1):123-129.
[8] Clifford V,Heffernan HM,Grimwood K,et al.Variation in erythromycin and clindamycin resistance patterns between New Zealand and Australian B streptococcus isolates[J].Aust N Z J Obstet Gynaecol,2011,51(4):328-332.
[9] Garland SM,Cottrill E,Markowski L,et al.Antimicrobial resistance in group B streptococcus:the Australian experience[J].J Med Microbiol,2011,60(2):230-235.
[10] Ferrieri P,Lynfield R,Creti R,et al.Serotype IV and invasive group B streptococcus disease in neonates,Minnesota,USA,2000-2010[J].Emerg Infect Dis,2013,19(4):551-558.
[11] Bergseng H,Afset JE,Radtke A,et al.Molecular and phenotypic characterization of invasive group B streptococcus strains from infants in Norway 2006-2007[J].Clin Microbiol Infect,2009,15(12):1182-1185.
[12] Martins ER,Andreu A,Correia P,et al.Group B streptococci causing neonatal infections in Barcelona are a stable clonal population:18-year surveillance[J].J Clin Microbiol,2011,49(8):2911-2918.
[13] Wang P,Ma Z,Tong J,et al.Serotype distribution,antimicrobial resistance,and molecular characterization of invasive group B Streptococcus isolates recovered from Chinese neonates[J].Int J Infect Dis,2015,37(8):115-118.
[14] Verani JR,McGee L,Schrag SJ,et al.Prevention of Perinatal Group B Streptococcal Disease Revised Guidelines from CDC,2010[J].MMWR Recomm Rep,2010,59(RR-10):1-36.
[15] Paoletti LC,Guttormsen HK,Christian MS,et al.Neither antibody to a group B streptococcal conjugate vaccine nor the vaccine itself is teratogenic in rabbits[J].Human Vaccines,2008,4(6):435-443.
[16] Nuccitelli A,Rinaudo CD,Maione D,Group B Streptococcus vaccine:state of the art[J].Ther Adv Vaccines,2015,3(3):76-90.
[17] Yang HH,Mascuch SJ,Madoff LC,et al.Recombinant group B Streptococcus alpha-like protein 3 is an effective immunogen and carrier protein[J].Clin Vaccine Immunol,2008,15(7):1035-1041.
[18] Maeland JA,Afset JE,Lyng RV,et al.Survey of immunological features of the Alpha-like proteins of streptococcus agalactiae[J].Clin Vaccine Immunol,2015,22(2):153-159.
[19] Santi I,Grifantini R,Jiang SM,et al.CsrRS regulates group B streptococcus virulence gene expression in response to environmental pH:a new perspective on vaccine development[J].J Bacteriol,2009,191(17):5387-5397.
[20] Jiang S,Park SE,Yadav P,et al.Regulation and function of Pilus island 1 in group B Streptococcus[J].J Bacteriol,2012,194(10):2479-2490.
[21] Pannaraj PS,Edwards MS,Ewing KT,et al.Group B streptococcal conjugate vaccines elicit functional antibodies independent of strain O-acetylation[J].Vaccine,2009,27(33):4452-4456.
[22] Morozumi M,Wajima T,Kuwata Y,et al.Associations between capsular serotype,multilocus sequence type,and macrolide resistance in Streptococcus agalactiae isolates from Japanese infants with invasive infections[J].Epidemiol Infect,2014,142(4):812-819.

新生儿B族溶血链球菌的耐药性及疫苗研究进展

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

[1]	. [J]. Chinese Journal of Child Health Care, 2024, 32(11): 1161-1162.
[2]	ZONG Xin'nan. History, achievements, problems and prospects of survey and research on physical growth and development of children in China [J]. Chinese Journal of Child Health Care, 2024, 32(11): 1163-1168.
[3]	LI Dongdan, WU Jie. Individualized nutritional management strategies for food allergy in children [J]. Chinese Journal of Child Health Care, 2024, 32(11): 1169-1172.
[4]	WANG Xi, LYU Huiling, HU Jiale, HAN Di, DING Ziyao, SHEN Hui, HU Jia. Association between the pubertal timing and high blood pressure in children and adolescents in Suzhou City [J]. Chinese Journal of Child Health Care, 2024, 32(11): 1173-1178.
[5]	CAI Bingyao, CAO Ying, ZHU Siying, CAO Da, JIANG Jianuo, DONG Yanhui, MA Jun. Influence of lifestyle on overweight and obesity, abnormally high blood pressure and their morbidity among college students in northern China [J]. Chinese Journal of Child Health Care, 2024, 32(11): 1179-1185.
[6]	DUAN Peifen, YUAN Jianhui, FENG Xiangxian. Effect of childhood obesity intervention on body shape perception and the mediating role of body shape perception in changes of obesity indicators [J]. Chinese Journal of Child Health Care, 2024, 32(11): 1186-1189.
[7]	HUANG Kun, LI Xiuhong, WU Jiaqi, CHEN Jin, HAN Xiaopu, LIN Rong. Association between outdoor activity time of students and scoliosis [J]. Chinese Journal of Child Health Care, 2024, 32(11): 1190-1195.
[8]	LIU Junting, LI Shaoli, CHEN Fangfang, ZONG Xinnan, HUANG Chunlei, ZHANG Tong, TAI Jun, GU Qinglong, On behalf of the Beijing Children and Adolescent Health Cohort Collaborative Group. Baseline characteristics analysis of the Beijing Children and Adolescents Natural Population Cohort [J]. Chinese Journal of Child Health Care, 2024, 32(11): 1212-1218.
[9]	ZHANG Fen, JIA Lina. Research progress on food preferences of children and adolescents [J]. Chinese Journal of Child Health Care, 2024, 32(11): 1219-1225.
[10]	WU Huahong, SHU Wen, YU Chengdong, ZHANG Yaqin, WU Ting, ZONG Xinnan. Meta-analysis of effect of calcium supplementation on children's height [J]. Chinese Journal of Child Health Care, 2024, 32(11): 1246-1251.
[11]	WU Shuxian, WU Qingqing, WANG Lei, ZHAO Xiang, LYU Qiaohong, HUANG Yu. Pathway of the effect of screen exposure on overweight and obesity among children and adolescents [J]. Chinese Journal of Child Health Care, 2024, 32(11): 1252-1255.
[12]	DING Yonggang, LI Libo, MA Zhen, ZARXI Quzha. Non-suicidal self-injurious behaviors and associations with help-seeking behaviors among Tibetan middle school students in agricultural and pastoral areas of Tibet [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1064-1069.
[13]	LIANG Guiye, GONG Jian, ZHOU Yue, GONG Linlin, WANG Yanni, XUE Hongli. Sleep health status and its influencing factors among primary and secondary school students in Lanzhou City [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1070-1075.
[14]	JIN Guihua, CUI Wenxiang. Comparison of the detection rates of new media dependence and addiction among adolescents with different family social capital in the Yanbian area [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1085-1090.
[15]	LI Tiangeng, GUO Liang, ZENG Sai, ZHENG Gangbin. Correlation of physical activity and sedentary behavior with cognitive development of preschool children [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1111-1115.