doi:10.11852/zgetbjzz2015-23-09-15

Abstract

摘要： 孤独症谱系障碍是一类发病于婴幼儿期的严重的神经发育障碍,发病率逐年增加,该病特征为社会沟通和社会交往障碍及受限制、重复性模式的行为模式,但导致这些症状的病因不明,寻找导致病症的潜在生物标志物有助于了解孤独症的病理机制,并有助于对疾病的早期诊断及早期干预。国内外已经在寻找生物学标记物方面进行了一些研究,本文对此做一综述,并展望未来的发展。

关键词: 孤独症, 生物学标记, 早期诊断

CLC Number:

R749.94

吴梅荣综述, 徐海青审校. 孤独症早期诊断生物学标记研究进展[J]. 中国儿童保健杂志, 2015, 23(9): 944-946.

[1] 万玉美,胡强,李婷,等.中国儿童孤独症谱系障碍患病率的系统综述[J].shanghai Archives of Psychiatry,2013,25(2):70-80.
[2] Verhoeven JS,De Cock P,Lagae L,et al.Neuroimaging of autism[J].Neuroradiology,2010,52(11):3-14.
[3] Perry EK,Lee ML,Martin-Ruiz CM,et al.Cholinergic activity in autism:abnormalities in the cerebral cortex and basal forebrain[J].Am J Psychiatry,2001,158(7):1058-1066.
[4] Laila Y,Avadhi AL.Relationship between sonic hedgehog protein,brain-derived neurotrophic factor and oxidative stress in autism spectrum disorders[J].Neurochem Res,2012,37(2):394-400.
[5] 彭志晴,赵栋.孤独症儿童血清中脑源性神经营养因子的水平[J].中华疾病控制杂志,2014,18(1):1-4.
[6] 周家秀,郭兰婷,吴康敏,等.BDNF基因二核苷酸多态性与儿童孤独症的关联研究[J].中国实用儿科杂志,2006,21(12):933-935.
[7] 李家鑫,韦斌垣.BDNF 基因功能性多态rs6265 与孤独症儿童的相关性研究[J].中国现代医学杂志,2014,24(16):28-31.
[8] Kaether C,Haass C.A lipid boundary separates APP and secretases and limits amyloid beta-peptide generation[J].J Cell Biol,2004,167(5):809-812.
[9] Bailey AR,Giunta BN,Obregon D,et al.Peripheral biomarkers in Autism:secreted amyloid precursor protein-α as a probable key player in early diagnosis[J].Int J Clin Exp Med,2008,1(4):338-344.
[10] Ray B,Long JM,Sokol DK.Increased secreted amyloid precursor protein-a (sAPPa) in severe autism:proposal of a specific,anabolic pathway and putative biomarker [J].PLoS ONE,2011,6(6):e20405.
[11] Al- Ayadhi LY,Ben Bacha AG,Kotb M,et al.A novel study on amyloid β peptide 40,42 and 40/42 ratio in Saudi autistics[J].Behavioral and Brain Functions,2012,8(1):4-6.
[12] Rossignol DA,Frye RE.The use of medications approved for Alzheimer's disease in autism spectrum disorder:a systematic review[J].Front Pediatr,2014,2(1):87.
[13] Gogolla N,Leblanc JJ,Quast KB,et al.Common circuit defect of excitatory-inhibitory balance in mouse models of autism[J].Neurodev Disord,2009,1(2):172-181.
[14] 何益群,赵靖平,寻广磊,等.儿童孤独症的血浆谷氨酸和γ2氨基丁酸水平及其与伴发癫痫的关系[J].Chin J Nerv Ment Dis,2009,35(9):526-529.
[15] Alabdali A,Al-Ayadhi L,El-Ansary A.Association of social and cognitive impairment and biomarkers in autism spectrum disorders[J].Journal of Neuroinflammation,2014,11(4):1-14.
[16] Andre A,Goldani S,Downs SR,et al.Biomarkers in autism[J].Frontiers in psychiatry,2014,5(110):1-13.
[17] Meneses A.5-HT systems:emergent targets for memory formation and memory alterations[J].Rev Neurosci,2013,24(6):629-664.
[18] 霍健,苏兴利,王爽.儿童孤独症多巴胺转运体脑显像研究[J].临床儿科杂志,2014,32(4):323-325.
[19] 韦斌垣,黄飞,覃小田.利培酮在治疗孤独症儿童行为问题中的作用[J].中国当代儿科杂志,2011,13(3):216-218.
[20] American Psychiatric Association.Diagnostic and statistical manual of mental disorders[M].5^th ed.Washington,DC,American Psychiatric Association,2013.

孤独症早期诊断生物学标记研究进展

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

[1]	TANG Yajun, LIU Xiumei. Research progress on dietary nutrition and intestinal flora in children with tic disorder [J]. Chinese Journal of Child Health Care, 2024, 32(11): 1232-1235.
[2]	LIN Duan, LIU Xiumei. Research progress on the role of histamine in the pathogenesis of tic disorder [J]. Chinese Journal of Child Health Care, 2024, 32(11): 1236-1240.
[3]	CHEN Yanhui, KE Zhongling. Psycho-behavioral intervention for tic disorder based on neurophysioloy [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1045-1049.
[4]	LU Yanting, CHEN Liangliang, LIU Xiumei. Mediating role of premonitory urge on the impact of comorbidity with attention-deficit/hyperactivity disorder on tic severity in children with tic disorder [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1050-1054.
[5]	GAN Kaiyan, HUANG Anqi, ZHANG Ziyi, GUAN Luyang, WANG Fei, KE Xiaoyan. Prospective study of the stability of early diagnosis of autism spectrum disorder with positive screening results of Modified Checklist for Autism in Toddlers [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1076-1079.
[6]	YANG Fan, LI Qinghong, LI Yiming, YANG Shunbo, LI Wei, LYU Zhihai. Status of screen use and its association with core symptoms in children with autism spectrum disorder [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1080-1084.
[7]	ZHANG Panpan, ZHAO Tingting, XIAO Xuwu. Correlation between intestinal flora and tic disorder [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1091-1096.
[8]	QIU Jiaqi , ZHONG Xia, ZOU Shipu. Role of dopamine and its receptors in tic disorder in children [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1097-1100.
[9]	XU Ying, SHI Haishui, ZHANG Huifeng, TIAN Xiaoyu. Role of GABAergic system in the pathogenesis and treatment of Tourette syndrome in children [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1101-1105.
[10]	LI Zhonggui, WANG Haifei, HUANG Meilin, JING Jin. Cognitive impairments of children with tic disorder [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1106-1110.
[11]	LI Shuai, HUANG Qijun, XIA Yu, LIU Zhenhuan. Meta-analysis of the correlation of prenatal, perinatal and environmental risk factors with childhood autism [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1122-1127.
[12]	JIANG Yanlin, WANG Junhong, LI Jialin, ZHAI Rui, JIANG Xiulei. Construction of a risk prediction scoring system for tic disorders in Chinese children based on Meta-analysis and external validation [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1128-1134.
[13]	ZHANG Liwen, QIN Xing, LI Juan, SONG Zixia, WU Weiwei. Efficacy of EEG biofeedback combined with methylphenidate hydrochloride in the treatment of childhood attention deficit hyperactivity disorder and its effect on cerebral blood flow and serum cortisol level [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1135-1139.
[14]	DONG Chao, ZHANG Linlin, ZHONG Yunyu, LIU Yun, LIU Juan, WANG Peng, WANG Yufeng, YANG Binrang, WU Zhaomin, LI Ying. Multidimensional executive function deficits in children with attention deficit hyperactivity disorder assessed by Cambridge Neuropsychological Test Automated Battery [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1149-1154.
[15]	WANG Yu, MA Xiaoping, YAO Rui, DU Tianju, LI Hua, LIU Li. Genetic etiology analysis of children with developmental delay and intellectual disabilities in Ningxia region [J]. Chinese Journal of Child Health Care, 2024, 32(9): 1008-1013.